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ENZYME entry: EC 1.14.19.71

Accepted Name
Fumitremorgin C synthase.
Reaction catalysed
Tryprostatin A + [reduced NADPH--hemoprotein reductase] + O(2) <=> fumitremorgin C + [oxidized NADPH--hemoprotein reductase] + 2 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • A cytochrome P450 (heme-thiolate) protein.
  • The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C.
  • Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
  • Formerly EC 1.14.21.10.
Cross-references
BRENDA1.14.19.71
EC2PDB1.14.19.71
ExplorEnz1.14.19.71
PRIAM enzyme-specific profiles1.14.19.71
KEGG Ligand Database for Enzyme Nomenclature1.14.19.71
IUBMB Enzyme Nomenclature1.14.19.71
IntEnz1.14.19.71
MEDLINEFind literature relating to 1.14.19.71
MetaCyc1.14.19.71
Rhea expert-curated reactions1.14.19.71
UniProtKB/Swiss-Prot
B9WZX4, FTME_ASPFM;  Q4WAW8, FTME_ASPFU;  A1DA63, FTME_NEOFI;  

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