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ENZYME entry: EC 1.14.19.77

Accepted Name
plasmanylethanolamine desaturase.
Alternative Name(s)
2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase.
alkylacylglycerophosphoethanolamine desaturase.
Reaction catalysed
1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Comment(s)
  • The enzyme catalyzes the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine.
  • The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
  • Formerly EC 1.14.99.19.
Cross-references
BRENDA1.14.19.77
EC2PDB1.14.19.77
ExplorEnz1.14.19.77
PRIAM enzyme-specific profiles1.14.19.77
KEGG Ligand Database for Enzyme Nomenclature1.14.19.77
IUBMB Enzyme Nomenclature1.14.19.77
IntEnz1.14.19.77
MEDLINEFind literature relating to 1.14.19.77
MetaCyc1.14.19.77
Rhea expert-curated reactions1.14.19.77
UniProtKB/Swiss-Prot
Q9AE87, CARF_MYXXA;  A6QLM0, PDES1_BOVIN;  A5PLL7, PDES1_HUMAN;  
Q99LQ7, PDES1_MOUSE;  

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