ENZYME entry: EC 1.14.19.77

Accepted Name

plasmanylethanolamine desaturase

Alternative Name(s)

2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase

alkylacylglycerophosphoethanolamine desaturase

Reaction catalysed

1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + 2 H(+) + O2 <=> 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Comment(s)

The enzyme catalyzes the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine.
The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
Formerly EC 1.14.99.19.

Cross-references

BRENDA

1.14.19.77

EC2PDB

1.14.19.77

ExplorEnz

1.14.19.77

PRIAM enzyme-specific profiles

1.14.19.77

KEGG Ligand Database for Enzyme Nomenclature

1.14.19.77

IUBMB Enzyme Nomenclature

1.14.19.77

IntEnz

1.14.19.77

MEDLINE

Find literature relating to 1.14.19.77

MetaCyc

1.14.19.77

Rhea expert-curated reactions

1.14.19.77

UniProtKB/Swiss-Prot

Q9AE87, CARF_MYXXA	A6QLM0, PDES1_BOVIN	A5PLL7, PDES1_HUMAN
Q99LQ7, PDES1_MOUSE

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