ID   1.14.19.80
DE   (19E)-geissoschizine oxidase.
AN   CYP71D1V1.
CA   (19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 =
CA   akuammicine + formate + oxidized [NADPH--hemoprotein reductase] + H2O +
CA   H(+).
CC   -!- A cytochrome P450 (heme-thiolate) enzyme characterized from the plant
CC       Catharanthus roseus (Madagascar periwinkle), that participates in the
CC       biosynthesis of a number of monoterpene alkaloids, as well as the
CC       bisindole alkaloids vinblastine and vincristine.
CC   -!- The enzyme generates a nine-carbon ring that contains a nitrogen
CC       atom.
CC   -!- The direct product of the enzyme, 3,17-didehydrostemmadenine,
CC       is unstable, and in the absence of other enzymes becomes akuammicine
CC       non-enzymically.
CC   -!- However, in the presence of two dehydrogenases it is converted to
CC       stemmadenine via 17-dehydrostemmadenine.
DR   A0A9E7S4M4, GO_ALSSC   ;  I1TEM0, GO_CATRO   ;  P0DO79, GO_STRNX   ;
DR   P0DO88, GO_STRYX   ;  A0A9E7S4M3, RHS_ALSSC  ;
//