ID   1.14.19.9
DE   tryptophan 7-halogenase.
CA   chloride + FADH2 + L-tryptophan + O2 = 7-chloro-L-tryptophan + FAD +
CA   2 H2O.
CC   -!- A flavin-dependent halogenase.
CC   -!- The enzyme from the bacterium Lechevalieria aerocolonigenes catalyzes
CC       the initial step in the biosynthesis of rebeccamycin.
CC   -!- It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving
CC       C4a-hydroperoxyflavin, which then reacts with chloride to produce a
CC       hypochlorite ion.
CC   -!- The latter reacts with an active site lysine to generate a
CC       chloramine, which chlorinates the substrate.
CC   -!- Also acts on bromide ion. cf. EC 1.14.19.58 and EC 1.14.19.59.
CC   -!- Formerly EC 1.14.14.7.
DR   A8CF75, TRP7H_KUTS7;  Q8KHZ8, TRP7H_LENAE;  P95480, TRP7H_PSEFL;
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