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ENZYME

ENZYME entry: EC 1.14.20.3

PURL: https://purl.expasy.org/enzyme/EC/1.14.20.3
Accepted Name
(5R)-carbapenem-3-carboxylate synthase
Reaction catalysed
(3S,5S)-carbapenam-3-caboxylate + 2-oxoglutarate + O2 = (5R)-carbapenem-3-carboxylate + succinate + CO2 + H2O
Comment(s)
  • The enzyme is involved in the biosynthesis of the carbapenem beta- lactam antibiotic (5R)-carbapen-2-em-3-carboxylate in the bacterium Pectobacterium carotovorum.
  • It catalyzes a stereoinversion at C(5) and introduces a double bond between C-2 and C-3.
Cross-references
BRENDA1.14.20.3
EC2PDB1.14.20.3
ExplorEnz1.14.20.3
KEGG Ligand Database for Enzyme Nomenclature1.14.20.3
IUBMB Enzyme Nomenclature1.14.20.3
MEDLINEFind literature relating to 1.14.20.3
MetaCyc1.14.20.3
Rhea expert-curated reactions1.14.20.3
UniProtKB/Swiss-Prot
Q9XB59, CARC_PECCC

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