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ENZYME

ENZYME entry: EC 1.14.20.6

PURL: https://purl.expasy.org/enzyme/EC/1.14.20.6
Accepted Name
flavonol synthase
Alternative Name(s)
flavonoid 2-oxoglutarate-dependent dioxygenase
FLS
Reaction catalysed
a (2R,3R)-dihydroflavonol + 2-oxoglutarate + O2 = a flavonol + succinate + CO2 + H2O
Comment(s)
  • In addition to the desaturation of (2R,3R)-dihydroflavonols to flavonols, the enzyme from the satsuma Citrus unshiu also has a non- specific activity that trans-hydroxylates the flavanones (2S)- naringenin and the unnatural (2R)-naringenin at C-3 to kaempferol and (2R,3R)-dihydrokaempferol, respectively.
  • Formerly EC 1.14.11.23.
Cross-references
BRENDA1.14.20.6
EC2PDB1.14.20.6
ExplorEnz1.14.20.6
KEGG Ligand Database for Enzyme Nomenclature1.14.20.6
IUBMB Enzyme Nomenclature1.14.20.6
MEDLINEFind literature relating to 1.14.20.6
MetaCyc1.14.20.6
Rhea expert-curated reactions1.14.20.6
UniProtKB/Swiss-Prot
Q96330, FLS1_ARATHA0A4D6Q440, FLS1_CROXCQ9FFQ5, FLS3_ARATH
F4KAS1, FLS4_ARATHQ9FFQ4, FLS5_ARATHF4K7D5, FLS6_ARATH
Q9ZWQ9, FLS_CITUNQ9M547, FLS_EUSRUQ9XHG2, FLS_MALDO
O04395, FLS_MATINQ7XZQ6, FLS_PETCRQ07512, FLS_PETHY
Q41452, FLS_SOLTU

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