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ENZYME entry: EC 1.14.20.8

Accepted Name
(-)-deoxypodophyllotoxin synthase.
Reaction catalysed
(-)-yatein + 2-oxoglutarate + O(2) <=> (-)-deoxypodophyllotoxin + succinate + CO(2) + H(2)O
Comment(s)
  • The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non- alkaloid toxin lignan whose derivatives are important anticancer drugs.
  • It catalyzes the closure of the central six-membered ring in the aryltetralin scaffold.
  • Formerly EC 1.14.11.50.
Cross-references
BRENDA1.14.20.8
EC2PDB1.14.20.8
ExplorEnz1.14.20.8
PRIAM enzyme-specific profiles1.14.20.8
KEGG Ligand Database for Enzyme Nomenclature1.14.20.8
IUBMB Enzyme Nomenclature1.14.20.8
IntEnz1.14.20.8
MEDLINEFind literature relating to 1.14.20.8
MetaCyc1.14.20.8
Rhea expert-curated reactions1.14.20.8
UniProtKB/Swiss-Prot
A0A0N9HQ36, 2ODD_SINHE

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