A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.99.46

Accepted Name
Pyrimidine monooxygenase.
Reaction catalysed
  • Uracil + FMNH(2) + O(2) <=> (Z)-3-ureidoacrylate peracid + FMN + H(2)O
  • Thymine + FMNH(2) + O(2) <=> (Z)-2-methylureidoacrylate peracid + FMN + H(2)O
Comment(s)
  • In vitro the product (Z)-3-ureidoacrylate peracid is spontaneously reduced into ureidoacrylate.
  • Part of the Rut pyrimidine catabolic pathway.
  • Formerly EC 1.14.14.n1.
Cross-references
BRENDA1.14.99.46
EC2PDB1.14.99.46
ExplorEnz1.14.99.46
PRIAM enzyme-specific profiles1.14.99.46
KEGG Ligand Database for Enzyme Nomenclature1.14.99.46
IUBMB Enzyme Nomenclature1.14.99.46
IntEnz1.14.99.46
MEDLINEFind literature relating to 1.14.99.46
MetaCyc1.14.99.46
UniProtKB/Swiss-Prot
Q6FFZ7, RUTA_ACIAD;  P58759, RUTA_AGRFC;  B9JLT9, RUTA_AGRRK;  
B9K4P2, RUTA_AGRVS;  A5EB33, RUTA_BRASB;  B0SW63, RUTA_CAUSK;  
D5VGV4, RUTA_CAUST;  Q9A4N2, RUTA_CAUVC;  B8H1Q4, RUTA_CAUVN;  
A7ME52, RUTA_CROS8;  C9Y0S7, RUTA_CROTZ;  C8U5H4, RUTA_ECO10;  
C8UMM8, RUTA_ECO1A;  A7ZKB7, RUTA_ECO24;  C8TNC2, RUTA_ECO26;  
B7UNZ5, RUTA_ECO27;  D3H125, RUTA_ECO44;  B7MIF9, RUTA_ECO45;  
B7LFC2, RUTA_ECO55;  Q8XAU1, RUTA_ECO57;  B5YU53, RUTA_ECO5E;  
C6UPN4, RUTA_ECO5T;  B7NLB4, RUTA_ECO7I;  B7MTF5, RUTA_ECO81;  
B7M8Z7, RUTA_ECO8A;  C6EHJ5, RUTA_ECOBD;  C6UFC3, RUTA_ECOBR;  
C4ZQE0, RUTA_ECOBW;  D3QPK5, RUTA_ECOCB;  C9QZ64, RUTA_ECOD1;  
B1X9D3, RUTA_ECODH;  A7ZYW7, RUTA_ECOHS;  A1A9R7, RUTA_ECOK1;  
D5CZH2, RUTA_ECOKI;  Q0TJ55, RUTA_ECOL5;  Q8FJ41, RUTA_ECOL6;  
B1IV85, RUTA_ECOLC;  P75898, RUTA_ECOLI;  B7N3G8, RUTA_ECOLU;  
D2NGI9, RUTA_ECOS5;  B6I988, RUTA_ECOSE;  B1LIZ3, RUTA_ECOSM;  
Q1RDK5, RUTA_ECOUT;  A4W925, RUTA_ENT38;  D5CE32, RUTA_ENTCC;  
D0LI58, RUTA_HALO1;  B5XXN0, RUTA_KLEP3;  A6T7A2, RUTA_KLEP7;  
D3RKL0, RUTA_KLEVT;  B7KWT7, RUTA_METC4;  C5B0U9, RUTA_METEA;  
C7CM36, RUTA_METED;  A9W3I1, RUTA_METEP;  B1ZB15, RUTA_METPB;  
B1M6B9, RUTA_METRJ;  D4GEU4, RUTA_PANAM;  Q48MQ4, RUTA_PSE14;  
Q4ZXR7, RUTA_PSEU2;  A4VQH4, RUTA_PSEU5;  A8GCT6, RUTA_SERP5;  
Q32HQ0, RUTA_SHIDS;  D2AC43, RUTA_SHIF2;  Q0T622, RUTA_SHIF8;  
Q83LK6, RUTA_SHIFL;  C5CN79, RUTA_VARPS;  A1JMY1, RUTA_YERE8;  

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