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ENZYME

ENZYME entry: EC 1.14.99.46

Accepted Name
pyrimidine monooxygenase
Reaction catalysed
  • FMNH2 + NADH + O2 + uracil <=> (Z)-3-ureidoacrylate + FMN + H(+) + H2O + NAD(+)
  • FMNH2 + NADH + O2 + thymine <=> (Z)-2-methylureidoacrylate + FMN + H(+) + H2O + NAD(+)
Comment(s)
  • The enzyme participates in the Rut pyrimidine catabolic pathway.
  • The flavin-N(5)-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
  • Formerly EC 1.14.14.n1.
Cross-references
BRENDA1.14.99.46
EC2PDB1.14.99.46
ExplorEnz1.14.99.46
PRIAM enzyme-specific profiles1.14.99.46
KEGG Ligand Database for Enzyme Nomenclature1.14.99.46
IUBMB Enzyme Nomenclature1.14.99.46
IntEnz1.14.99.46
MEDLINEFind literature relating to 1.14.99.46
MetaCyc1.14.99.46
Rhea expert-curated reactions1.14.99.46
UniProtKB/Swiss-Prot
Q6FFZ7, RUTA_ACIADP58759, RUTA_AGRFCB9JLT9, RUTA_AGRRK
B9K4P2, RUTA_AGRVSA5EB33, RUTA_BRASBB0SW63, RUTA_CAUSK
D5VGV4, RUTA_CAUSTQ9A4N2, RUTA_CAUVCB8H1Q4, RUTA_CAUVN
A7ME52, RUTA_CROS8C9Y0S7, RUTA_CROTZC8U5H4, RUTA_ECO10
C8UMM8, RUTA_ECO1AA7ZKB7, RUTA_ECO24C8TNC2, RUTA_ECO26
B7UNZ5, RUTA_ECO27D3H125, RUTA_ECO44B7MIF9, RUTA_ECO45
B7LFC2, RUTA_ECO55Q8XAU1, RUTA_ECO57B5YU53, RUTA_ECO5E
C6UPN4, RUTA_ECO5TB7NLB4, RUTA_ECO7IB7MTF5, RUTA_ECO81
B7M8Z7, RUTA_ECO8AC6EHJ5, RUTA_ECOBDC6UFC3, RUTA_ECOBR
C4ZQE0, RUTA_ECOBWD3QPK5, RUTA_ECOCBC9QZ64, RUTA_ECOD1
B1X9D3, RUTA_ECODHA7ZYW7, RUTA_ECOHSA1A9R7, RUTA_ECOK1
D5CZH2, RUTA_ECOKIQ0TJ55, RUTA_ECOL5Q8FJ41, RUTA_ECOL6
B1IV85, RUTA_ECOLCP75898, RUTA_ECOLIB7N3G8, RUTA_ECOLU
D2NGI9, RUTA_ECOS5B6I988, RUTA_ECOSEB1LIZ3, RUTA_ECOSM
Q1RDK5, RUTA_ECOUTA4W925, RUTA_ENT38D5CE32, RUTA_ENTCC
D0LI58, RUTA_HALO1B5XXN0, RUTA_KLEP3A6T7A2, RUTA_KLEP7
D3RKL0, RUTA_KLEVTB7KWT7, RUTA_METC4C5B0U9, RUTA_METEA
C7CM36, RUTA_METEDA9W3I1, RUTA_METEPB1ZB15, RUTA_METPB
B1M6B9, RUTA_METRJD4GEU4, RUTA_PANAMQ48MQ4, RUTA_PSE14
Q4ZXR7, RUTA_PSEU2A4VQH4, RUTA_PSEU5A8GCT6, RUTA_SERP5
Q32HQ0, RUTA_SHIDSD2AC43, RUTA_SHIF2Q0T622, RUTA_SHIF8
Q83LK6, RUTA_SHIFLC5CN79, RUTA_VARPSA1JMY1, RUTA_YERE8

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