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ENZYME

ENZYME entry: EC 1.14.99.46

PURL: https://purl.expasy.org/enzyme/EC/1.14.99.46
Accepted Name
pyrimidine monooxygenase
Reaction catalysed
  • uracil + FMNH2 + NADH + O2 = (Z)-3-ureidoacrylate + FMN + NAD(+) + H2O + H(+)
  • thymine + FMNH2 + NADH + O2 = (Z)-2-methylureidoacrylate + FMN + NAD(+) + H2O + H(+)
Comment(s)
  • The enzyme participates in the Rut pyrimidine catabolic pathway.
  • The flavin-N(5)-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule.
  • Formerly EC 1.14.14.n1.
Cross-references
BRENDA1.14.99.46
EC2PDB1.14.99.46
ExplorEnz1.14.99.46
KEGG Ligand Database for Enzyme Nomenclature1.14.99.46
IUBMB Enzyme Nomenclature1.14.99.46
MEDLINEFind literature relating to 1.14.99.46
MetaCyc1.14.99.46
Rhea expert-curated reactions1.14.99.46
UniProtKB/Swiss-Prot
Q6FFZ7, RUTA_ACIADP58759, RUTA_AGRFCB9K4P2, RUTA_ALLAM
A5EB33, RUTA_BRASBB0SW63, RUTA_CAUSKD5VGV4, RUTA_CAUST
Q9A4N2, RUTA_CAUVCB8H1Q4, RUTA_CAUVNA7ME52, RUTA_CROS8
C9Y0S7, RUTA_CROTZC8U5H4, RUTA_ECO10C8UMM8, RUTA_ECO1A
A7ZKB7, RUTA_ECO24C8TNC2, RUTA_ECO26B7UNZ5, RUTA_ECO27
D3H125, RUTA_ECO44B7MIF9, RUTA_ECO45B7LFC2, RUTA_ECO55
Q8XAU1, RUTA_ECO57B5YU53, RUTA_ECO5EC6UPN4, RUTA_ECO5T
B7NLB4, RUTA_ECO7IB7MTF5, RUTA_ECO81B7M8Z7, RUTA_ECO8A
C6EHJ5, RUTA_ECOBDC6UFC3, RUTA_ECOBRC4ZQE0, RUTA_ECOBW
D3QPK5, RUTA_ECOCBC9QZ64, RUTA_ECOD1B1X9D3, RUTA_ECODH
A7ZYW7, RUTA_ECOHSA1A9R7, RUTA_ECOK1D5CZH2, RUTA_ECOKI
Q0TJ55, RUTA_ECOL5Q8FJ41, RUTA_ECOL6B1IV85, RUTA_ECOLC
P75898, RUTA_ECOLIB7N3G8, RUTA_ECOLUD2NGI9, RUTA_ECOS5
B6I988, RUTA_ECOSEB1LIZ3, RUTA_ECOSMQ1RDK5, RUTA_ECOUT
A4W925, RUTA_ENT38D5CE32, RUTA_ENTCCD0LI58, RUTA_HALO1
B5XXN0, RUTA_KLEP3A6T7A2, RUTA_KLEP7D3RKL0, RUTA_KLEVT
B7KWT7, RUTA_METC4C5B0U9, RUTA_METEAC7CM36, RUTA_METED
A9W3I1, RUTA_METEPB1ZB15, RUTA_METPBB1M6B9, RUTA_METRJ
D4GEU4, RUTA_PANAMQ48MQ4, RUTA_PSE14Q4ZXR7, RUTA_PSEU2
B9JLT9, RUTA_RHIR8A8GCT6, RUTA_SERP5Q32HQ0, RUTA_SHIDS
D2AC43, RUTA_SHIF2Q0T622, RUTA_SHIF8Q83LK6, RUTA_SHIFL
A4VQH4, RUTA_STUS1C5CN79, RUTA_VARPSA1JMY1, RUTA_YERE8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
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