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ENZYME

ENZYME entry: EC 1.14.99.48

PURL: https://purl.expasy.org/enzyme/EC/1.14.99.48
Accepted Name
heme oxygenase (staphylobilin-producing)
Alternative Name(s)
heme oxidase
heme oxygenase
heme oxygenase (decyclizing)
Reaction catalysed
  • heme b + 5 AH2 + 4 O2 + 2 H(+) = delta-staphylobilin + Fe(2+) + formaldehyde + 5 A + 4 H2O
  • heme b + 5 AH2 + 4 O2 + 2 H(+) = beta-staphylobilin + Fe(2+) + formaldehyde + 5 A + 4 H2O
Comment(s)
  • This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin.
  • The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % delta- staphylobilin, respectively.
Cross-references
BRENDA1.14.99.48
EC2PDB1.14.99.48
ExplorEnz1.14.99.48
KEGG Ligand Database for Enzyme Nomenclature1.14.99.48
IUBMB Enzyme Nomenclature1.14.99.48
MEDLINEFind literature relating to 1.14.99.48
MetaCyc1.14.99.48
Rhea expert-curated reactions1.14.99.48
UniProtKB/Swiss-Prot
Q2FHU5, HDOX1_STAA3Q2FZE2, HDOX1_STAA8Q5HGU8, HDOX1_STAAC
A6QG37, HDOX1_STAAEQ99UW8, HDOX1_STAAMQ7A649, HDOX1_STAAN
Q6GHV0, HDOX1_STAARQ6GA79, HDOX1_STAASQ8NX62, HDOX1_STAAW
Q2FK96, HDOX2_STAA3Q2G1J2, HDOX2_STAA8Q5HJK5, HDOX2_STAAC
A6QDF1, HDOX2_STAAEQ99X56, HDOX2_STAAMQ7A827, HDOX2_STAAN
Q6GKE0, HDOX2_STAARQ6GCW1, HDOX2_STAASQ7A1Y8, HDOX2_STAAW
A7WXE5, HDOX_STAA1Q2YX89, HDOX_STAABA8Z1R5, HDOX_STAAT
Q5HM56, HDOX_STAEQQ8CRK4, HDOX_STAESQ4L849, HDOX_STAHJ
Q49ZB8, HDOX_STAS1

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