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ENZYME

ENZYME entry: EC 1.14.99.53

PURL: https://purl.expasy.org/enzyme/EC/1.14.99.53
Accepted Name
lytic chitin monooxygenase
Alternative Name(s)
chitin oxidohydrolase
LPMO
Reaction catalysed
[(1->4)-N-acetyl-beta-D-glucosaminyl]n+m + reduced acceptor + O2 = [(1->4)-N-acetyl-beta-D-glucosaminyl]m-1-(1->4)-2-(acetylamino)-2-deoxy-D-glucono-1,5-lactone + [(1->4)-N-acetyl-beta-D-glucosaminyl]n + acceptor + H2O
Comment(s)
  • The enzyme cleaves chitin in an oxidative manner, releasing fragments of chitin with an N-acetylamino-D-glucono-1,5-lactone at the reducing end.
  • The initially formed lactone at the reducing end of the shortend chitin chain quickly hydrolyzes spontaneously to the aldonic acid.
  • In vitro ascorbate can serve as reducing agent.
Cross-references
BRENDA1.14.99.53
EC2PDB1.14.99.53
ExplorEnz1.14.99.53
KEGG Ligand Database for Enzyme Nomenclature1.14.99.53
IUBMB Enzyme Nomenclature1.14.99.53
MEDLINEFind literature relating to 1.14.99.53
MetaCyc1.14.99.53
Rhea expert-curated reactions1.14.99.53
UniProtKB/Swiss-Prot
Q838S1, LCHMO_ENTFAA3KIM2, LCHMO_STRA7

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