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ENZYME entry: EC 1.14.99.53

Accepted Name
Lytic chitin monooxygenase.
Alternative Name(s)
Chitin oxidohydrolase.
LPMO.
Reaction catalysed
((1->4)-N-acetyl-beta-D-glucosaminyl)(n+m) + reduced acceptor + O(2) <=> ((1->4)-N-acetyl-beta-D-glucosaminyl)(m-1)-(1->4)-2-(acetylamino)-2-deoxy-D-glucono-1,5-lactone + ((1->4)-N-acetyl-beta-D-glucosaminyl)(n) + acceptor + H(2)O
Cofactor(s)
Cu(2+).
Comment(s)
  • The enzyme cleaves chitin in an oxidative manner, releasing fragments of chitin with an N-acetylamino-D-glucono-1,5-lactone at the reducing end.
  • The initially formed lactone at the reducing end of the shortend chitin chain quickly hydrolyzes spontaneously to the aldonic acid.
  • In vitro ascorbate can serve as reducing agent.
Cross-references
BRENDA1.14.99.53
EC2PDB1.14.99.53
ExplorEnz1.14.99.53
PRIAM enzyme-specific profiles1.14.99.53
KEGG Ligand Database for Enzyme Nomenclature1.14.99.53
IUBMB Enzyme Nomenclature1.14.99.53
IntEnz1.14.99.53
MEDLINEFind literature relating to 1.14.99.53
MetaCyc1.14.99.53
UniProtKB/Swiss-Prot
Q838S1, LCHMO_ENTFA;  A3KIM2, LCHMO_STRA7;  

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