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ENZYME entry: EC 1.14.99.65

Accepted Name
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase.
Reaction catalysed
4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] + reduced acceptor + O(2) <=> 2-(4-aminophenyl)-L-seryl-[CmlP-peptidyl-carrier-protein] + acceptor + H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces venezuelae, participates in the biosynthesis of the antibiotic chloramphenicol.
  • It carries an oxygen-bridged dinuclear iron cluster.
  • The native electron donor remains unknown, and the enzyme was assayed in vitro using sodium dithionite.
  • The enzyme only acts on its substrate when it is loaded onto the peptidyl-carrier domain of the CmlP non-ribosomal peptide synthase.
Cross-references
BRENDA1.14.99.65
EC2PDB1.14.99.65
ExplorEnz1.14.99.65
PRIAM enzyme-specific profiles1.14.99.65
KEGG Ligand Database for Enzyme Nomenclature1.14.99.65
IUBMB Enzyme Nomenclature1.14.99.65
IntEnz1.14.99.65
MEDLINEFind literature relating to 1.14.99.65
MetaCyc1.14.99.65
Rhea expert-curated reactions1.14.99.65
UniProtKB/Swiss-Prot
F2RB80, CMLA_STRVP

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