ID   1.14.99.66
DE   [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
AN   lysine-specific histone demethylase 1.
CA   2 A + 2 H2O + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] = 2 AH2 +
CA   2 formaldehyde + L-lysyl(4)-[histone H3].
CC   -!- The enzyme specifically removes methyl groups from mono- and
CC       dimethylated lysine(4) of histone 3.
CC   -!- During the reaction the substrate is oxidized by the FAD cofactor of
CC       the enzyme to generate the corresponding imine, which is subsequently
CC       hydrolyzed in the form of formaldehyde.
CC   -!- The enzyme is similar to flavin amine oxidases, and differs from all
CC       other known histone lysine demethylases, which are iron(II)- and
CC       2-oxoglutarate-dependent dioxygenases.
CC   -!- The physiological electron acceptor is not known with certainty. In
CC       vitro the enzyme can use oxygen, which is reduced to hydrogen
CC       peroxide, but generation of hydrogen peroxide in the chromatin
CC       environment is unlikely as it will result in oxidative damage of DNA.
DR   Q9XWP6, KDM1A_CAEEL;  O60341, KDM1A_HUMAN;  Q6ZQ88, KDM1A_MOUSE;
DR   Q21988, KDM1B_CAEEL;  Q8NB78, KDM1B_HUMAN;  Q8CIG3, KDM1B_MOUSE;
//