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ENZYME entry: EC 1.16.1.8

Accepted Name
[methionine synthase] reductase.
Alternative Name(s)
[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing).
methionine synthase cob(II)alamin reductase (methylating).
methionine synthase reductase.
Reaction catalysed
H(+) + 2 methylcob(III)alamin-[methionine synthase] + NADP(+) + 2 S-adenosyl-L-homocysteine <=> 2 cob(II)alamin-[methionine synthase] + NADPH + 2 S-adenosyl-L-methionine
Comment(s)
  • The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13.
  • Electrons are transferred from NADPH to FAD to FMN.
  • Formerly EC 2.1.1.135.
Cross-references
BRENDA1.16.1.8
EC2PDB1.16.1.8
ExplorEnz1.16.1.8
PRIAM enzyme-specific profiles1.16.1.8
KEGG Ligand Database for Enzyme Nomenclature1.16.1.8
IUBMB Enzyme Nomenclature1.16.1.8
IntEnz1.16.1.8
MEDLINEFind literature relating to 1.16.1.8
MetaCyc1.16.1.8
Rhea expert-curated reactions1.16.1.8
UniProtKB/Swiss-Prot
Q4JIJ2, MTRR_BOVIN;  Q17574, MTRR_CAEEL;  Q9UBK8, MTRR_HUMAN;  
Q8C1A3, MTRR_MOUSE;  Q498R1, MTRR_RAT;  

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