ID   1.16.3.4
DE   cuproxidase.
AN   copper efflux oxidase.
AN   Cu(I) oxidase.
AN   cuprous oxidase.
CA   4 Cu(+) + 4 H(+) + O2 = 4 Cu(2+) + 2 H2O.
CC   -!- The enzyme, characterized from the bacterium Escherichia coli,
CC       is involved in copper tolerance under aerobic conditions.
CC   -!- The enzyme contains a substrate binding (type 1) copper site and a
CC       trinuclear copper center (consisting of type 2 and type 3 copper
CC       sites) in which oxygen binding and reduction takes place.
CC   -!- It also contains a methionine rich region that can bind additional
CC       copper ions. In vitro, if the substrate binding site is occupied by
CC       copper(II), the enzyme can function as a laccase-type quinol oxidase.
CC   -!- However, in vivo this site is occupied by a copper(I) ion and the
CC       enzyme functions as a cuprous oxidase.
DR   P00450, CERU_HUMAN ;  Q61147, CERU_MOUSE ;  P13635, CERU_RAT   ;
DR   Q9XT27, CERU_SHEEP ;  Q8X947, CUEO_ECO57 ;  P36649, CUEO_ECOLI ;
DR   Q8Z9E1, CUEO_SALTI ;  Q8ZRS2, CUEO_SALTY ;  Q8ZBK0, CUEO_YERPE ;
DR   P38993, FET3_YEAST ;
//