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ENZYME entry: EC 1.17.1.3

Accepted Name
Leucoanthocyanidin reductase.
Alternative Name(s)
Leucocyanidin reductase.
Reaction catalysed
(2R,3S)-catechin + NADP(+) + H(2)O <=> 2,3-trans-3,4-cis-leucocyanidin + NADPH
Comment(s)
  • Catalyzes the synthesis of catechin, catechin-4-beta-ol (leucocyanidin) and the related flavan-3-ols afzelechin and gallocatechin, which are initiating monomers in the synthesis of plant polymeric proanthocyanidins or condensed tannins.
  • While 2,3-trans-3,4-cis-leucocyanidin is the preferred flavan-3,4- diol substrate, 2,3-trans-3,4-cis-leucodelphinidin and 2,3-trans-3, 4-cis-leucopelargonidin can also act as substrates, but more slowly.
  • NADH can replace NADPH but is oxidized more slowly.
Cross-references
BRENDA1.17.1.3
EC2PDB1.17.1.3
ExplorEnz1.17.1.3
PRIAM enzyme-specific profiles1.17.1.3
KEGG Ligand Database for Enzyme Nomenclature1.17.1.3
IUBMB Enzyme Nomenclature1.17.1.3
IntEnz1.17.1.3
MEDLINEFind literature relating to 1.17.1.3
MetaCyc1.17.1.3
Rhea expert-curated reactions1.17.1.3
UniProtKB/Swiss-Prot
Q84V83, LAR_DESUN

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