ID 1.17.1.5 DE nicotinate dehydrogenase. AN nicotinate hydroxylase. AN nicotinic acid hydroxylase. CA H2O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH. CC -!- The enzyme is capable of acting on a variety of nicotinate analogs to CC varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- CC dicarboxylate, trigonelline and 6-methylnicotinate. CC -!- The enzyme from Clostridium barkeri also possesses a catalytically CC essential, labile selenium that can be removed by reaction with CC cyanide. CC -!- Forms part of the nicotinate-fermentation catabolism pathway in CC Eubacterium barkeri. CC -!- Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, CC EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32. CC -!- Formerly EC 1.5.1.13. DR Q0QLF4, NDFS_EUBBA ; Q0QLF2, NDLMS_EUBBA; Q0QLF1, NDMMS_EUBBA; DR Q0QLF3, NDSFS_EUBBA; //