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ENZYME

ENZYME entry: EC 1.17.1.8

Accepted Name
4-hydroxy-tetrahydrodipicolinate reductase
Alternative Name(s)
dihydrodipicolinate reductase
Reaction catalysed
  • (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH
  • (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH
Comment(s)
  • The substrate of the enzyme was initially thought to be (S)-2,3- dihydrodipicolinate, and the enzyme was classified accordingly as EC 1.3.1.26.
  • Later studies of the enzyme from the bacterium Escherichia coli have suggested that the actual substrate of the enzyme is (2S,4S)-4- hydroxy-2,3,4,5-tetrahydrodipicolinate, and that its activity includes a dehydration step, and thus the enzyme has been reclassified as 4-hydroxy-tetrahydrodipicolinate reductase.
  • However, the identity of the substrate is still controversial, as more recently it has been suggested that it may be (S)-2,3- dihydrodipicolinate after all.
  • Formerly EC 1.3.1.26.
Cross-references
BRENDA1.17.1.8
EC2PDB1.17.1.8
ExplorEnz1.17.1.8
PRIAM enzyme-specific profiles1.17.1.8
KEGG Ligand Database for Enzyme Nomenclature1.17.1.8
IUBMB Enzyme Nomenclature1.17.1.8
IntEnz1.17.1.8
MEDLINEFind literature relating to 1.17.1.8
MetaCyc1.17.1.8
Rhea expert-curated reactions1.17.1.8
UniProtKB/Swiss-Prot
O80574, DAPB1_ARATHQ67W29, DAPB1_ORYSJP58210, DAPB1_RHILO
Q8LB01, DAPB2_ARATHQ10P67, DAPB2_ORYSJP58211, DAPB2_RHILO
B0CE31, DAPB_ACAM1Q6F6R2, DAPB_ACIADB7GV10, DAPB_ACIB3
B7I2B0, DAPB_ACIB5B2I2G4, DAPB_ACIBCB0VPZ8, DAPB_ACIBS
A3MA87, DAPB_ACIBTB0VA26, DAPB_ACIBYA5FXD9, DAPB_ACICJ
A3N048, DAPB_ACTP2B3H1A7, DAPB_ACTP7B0BNW4, DAPB_ACTPJ
A6VPE4, DAPB_ACTSZA4SLF8, DAPB_AERS4B6JCI8, DAPB_AFIC5
Q8UIV8, DAPB_AGRFCB9J6R4, DAPB_AGRRKB9JYQ3, DAPB_AGRVS
B2UMF1, DAPB_AKKM8A8EWI3, DAPB_ALIB4Q5E7N0, DAPB_ALIF1
B5FA64, DAPB_ALIFMB6ENC8, DAPB_ALISLQ5WGQ4, DAPB_ALKCK
Q0A7E5, DAPB_ALKEHA6TT16, DAPB_ALKMQA8MF41, DAPB_ALKOO
B8JAN4, DAPB_ANAD2Q2IGX0, DAPB_ANADEA7H774, DAPB_ANADF
Q5PA93, DAPB_ANAMMB4UHF2, DAPB_ANASKO67061, DAPB_AQUAE
O29353, DAPB_ARCFUQ5P1G6, DAPB_AROAEC1DFM1, DAPB_AZOVD
C3P5Q2, DAPB_BACAAC3L8Q7, DAPB_BACACA0RBY6, DAPB_BACAH
Q81SU0, DAPB_BACANB7JH17, DAPB_BACC0Q73AW1, DAPB_BACC1
B7IPB0, DAPB_BACC2C1EN29, DAPB_BACC3B7HHT6, DAPB_BACC4
B7HL46, DAPB_BACC7A7GN70, DAPB_BACCNB9IVQ5, DAPB_BACCQ
Q81FP4, DAPB_BACCRQ63DK0, DAPB_BACCZQ6HL23, DAPB_BACHK
Q65I50, DAPB_BACLDA9VME3, DAPB_BACMKA8FEI3, DAPB_BACP2
P42976, DAPB_BACSUA7Z600, DAPB_BACVZA1UTM3, DAPB_BARBK
Q6G2G3, DAPB_BARHEQ6FZ13, DAPB_BARQUA9IXE5, DAPB_BART1
Q6MRM8, DAPB_BDEBAB2IBR8, DAPB_BEII9C5BWQ6, DAPB_BEUC1
B8DWI3, DAPB_BIFA0Q8G526, DAPB_BIFLOB7GUF6, DAPB_BIFLS
Q7VQK8, DAPB_BLOFLQ493S0, DAPB_BLOPBQ7WGH5, DAPB_BORBR
Q7W510, DAPB_BORPAQ9X6Y9, DAPB_BORPEQ89WK2, DAPB_BRADU
C0R175, DAPB_BRAHWA5E8K0, DAPB_BRASBA4YJP9, DAPB_BRASO
Q2YJN7, DAPB_BRUA2Q576R4, DAPB_BRUABQ8YDC8, DAPB_BRUME
Q8FV07, DAPB_BRUSUB8D8U7, DAPB_BUCA5P57246, DAPB_BUCAI
Q8K9Z5, DAPB_BUCAPB8D751, DAPB_BUCATP59474, DAPB_BUCBP
Q057Y0, DAPB_BUCCCB1YT08, DAPB_BURA4A0K4H7, DAPB_BURCH
B4EEW4, DAPB_BURCJQ0BIB8, DAPB_BURCMQ39JM8, DAPB_BURL3
A9AHB2, DAPB_BURM1A3MPI2, DAPB_BURM7A2S5J7, DAPB_BURM9
Q62H17, DAPB_BURMAA1V0H0, DAPB_BURMSB1JVG6, DAPB_BURO0
Q1BZ73, DAPB_BURO1A3NZB9, DAPB_BURP0Q3JNM7, DAPB_BURP1
A3NDK8, DAPB_BURP6Q63QT3, DAPB_BURPSQ2SZ94, DAPB_BURTA
A4JBH8, DAPB_BURVGQ8RBI6, DAPB_CALS4A7ZB70, DAPB_CAMC1
A7GWC2, DAPB_CAMC5A0RMR7, DAPB_CAMFFA7I316, DAPB_CAMHC
A8FJZ8, DAPB_CAMJ8A7H1R4, DAPB_CAMJDQ9PIT2, DAPB_CAMJE
A1VXS5, DAPB_CAMJJQ5HWX1, DAPB_CAMJRB9KDT6, DAPB_CAMLR
Q3ACY8, DAPB_CARHZQ9A2L1, DAPB_CAUVCA3PNF3, DAPB_CERS1
Q3IYU4, DAPB_CERS4A4WWP7, DAPB_CERS5B9KP40, DAPB_CERSK
Q11CB4, DAPB_CHESBQ5L5G4, DAPB_CHLABQ3APL9, DAPB_CHLCH
Q822G7, DAPB_CHLCVQ255G3, DAPB_CHLFFB3EG74, DAPB_CHLL2
Q3B619, DAPB_CHLL3Q9PK30, DAPB_CHLMUB3QKY9, DAPB_CHLP8
B3EN04, DAPB_CHLPBA1BI80, DAPB_CHLPDA4SD53, DAPB_CHLPM
Q9Z6L2, DAPB_CHLPNB3QYM8, DAPB_CHLT3Q3KLZ2, DAPB_CHLTA
Q8KBD8, DAPB_CHLTEO84369, DAPB_CHLTRQ1QSX7, DAPB_CHRSD
Q7NX34, DAPB_CHRVOB5EGX3, DAPB_CITBBA8ALS4, DAPB_CITK8
A5CSN2, DAPB_CLAM3B0RGX5, DAPB_CLAMSQ97GI8, DAPB_CLOAB
B2V5A9, DAPB_CLOBAB2TS69, DAPB_CLOBBA0PZM2, DAPB_CLONN
Q0TP54, DAPB_CLOP1Q8XJ55, DAPB_CLOPEQ0SRS4, DAPB_CLOPS
Q891S2, DAPB_CLOTEQ47YI6, DAPB_COLP3C3PH06, DAPB_CORA7
Q6NGP2, DAPB_CORDIQ8RQN0, DAPB_COREFA4QEY0, DAPB_CORGB
P40110, DAPB_CORGLQ4JV62, DAPB_CORJKB1VDC2, DAPB_CORU7
B6J4U6, DAPB_COXB1B6J2F3, DAPB_COXB2A9KC25, DAPB_COXBN
A9NA71, DAPB_COXBRP24703, DAPB_COXBUA7MI96, DAPB_CROS8
Q1LJ29, DAPB_CUPMCQ0K705, DAPB_CUPNHQ46XD7, DAPB_CUPPJ
B3R6R4, DAPB_CUPTRQ6A7P7, DAPB_CUTAKB8HRK9, DAPB_CYAP4
Q47HI9, DAPB_DECARQ3Z7V5, DAPB_DEHM1A5FQT3, DAPB_DEHMB
Q3ZXV5, DAPB_DEHMCB8J0P9, DAPB_DESDAB8FQZ3, DAPB_DESHD
Q24UK0, DAPB_DESHYQ6AR64, DAPB_DESPSQ72BM6, DAPB_DESVH
B8DJT5, DAPB_DESVMA1VDM6, DAPB_DESVVB5YEB2, DAPB_DICT6
B8E2S7, DAPB_DICTDA8LL24, DAPB_DINSHA7ZHC0, DAPB_ECO24
B7UI76, DAPB_ECO27B7MAF2, DAPB_ECO45B7L4F3, DAPB_ECO55
P58209, DAPB_ECO57B5YYC3, DAPB_ECO5EB7NHD5, DAPB_ECO7I
B7MNN7, DAPB_ECO81B7M0C7, DAPB_ECO8AC4ZPV7, DAPB_ECOBW
B1XBF6, DAPB_ECODHA7ZVX9, DAPB_ECOHSA1A780, DAPB_ECOK1
Q0TLW0, DAPB_ECOL5Q8FLB4, DAPB_ECOL6B1IRE5, DAPB_ECOLC
P04036, DAPB_ECOLIB7N7Q5, DAPB_ECOLUB6HYX9, DAPB_ECOSE
B1LFW1, DAPB_ECOSMQ1RGH0, DAPB_ECOUTC5B7N2, DAPB_EDWI9
Q3YRP2, DAPB_EHRCJQ2GH22, DAPB_EHRCRQ5FFT0, DAPB_EHRRG
Q5HAV4, DAPB_EHRRWA4W6E7, DAPB_ENT38Q834S6, DAPB_ENTFA
B2VH06, DAPB_ERWT9B7LWM1, DAPB_ESCF3B1YJ40, DAPB_EXIS2
C4L2D3, DAPB_EXISAB9M381, DAPB_GEODFQ5KXW6, DAPB_GEOKA
Q39Z66, DAPB_GEOMGQ74GT5, DAPB_GEOSLC6E9Q8, DAPB_GEOSM
A4IQ67, DAPB_GEOTNA5GD90, DAPB_GEOURB8F8Q1, DAPB_GLAP5
B7KBV6, DAPB_GLOC7Q7NLC0, DAPB_GLOVIA9HE99, DAPB_GLUDA
Q5FSK8, DAPB_GLUOXQ0BPE6, DAPB_GRABCA0LZI4, DAPB_GRAFK
Q7VLM6, DAPB_HAEDUQ4QKM7, DAPB_HAEI8A5UCB3, DAPB_HAEIE
A5UF10, DAPB_HAEIGP45153, DAPB_HAEINQ0I3N1, DAPB_HAES1
Q2SMM6, DAPB_HAHCHQ9KC93, DAPB_HALH5A1WX29, DAPB_HALHL
Q5V5D5, DAPB_HALMAQ17XF1, DAPB_HELAHQ7VIW7, DAPB_HELHP
B6JL92, DAPB_HELP2B5Z6N2, DAPB_HELPGQ1CU21, DAPB_HELPH
Q9ZLW6, DAPB_HELPJB2UTX8, DAPB_HELPSP94844, DAPB_HELPY
A4G8E2, DAPB_HERARB0UU27, DAPB_HISS2Q5QXL5, DAPB_IDILO
A6T235, DAPB_JANMAB5Y210, DAPB_KLEP3A6T4H8, DAPB_KLEP7
P45415, DAPB_KLEPNQ5FKQ8, DAPB_LACACA8YUT4, DAPB_LACH4
Q9CFC0, DAPB_LACLAA2RJS9, DAPB_LACLMQ02Y20, DAPB_LACLS
Q88W01, DAPB_LACPLC1D7H9, DAPB_LARHHQ1MRS7, DAPB_LAWIP
Q5X8U7, DAPB_LEGPAA5I9V1, DAPB_LEGPCQ5ZZ80, DAPB_LEGPH
Q5X090, DAPB_LEGPLQ04U79, DAPB_LEPBJQ053P2, DAPB_LEPBL
Q72U21, DAPB_LEPICQ8F133, DAPB_LEPINQ1WU20, DAPB_LIGS1
B2GC12, DAPB_LIMF3Q92AA1, DAPB_LISINC1KWK7, DAPB_LISMC
Q71YA8, DAPB_LISMFB8DC19, DAPB_LISMHQ8Y5Z6, DAPB_LISMO
A0AK12, DAPB_LISW6B1HTF0, DAPB_LYSSCA0L4Z4, DAPB_MAGMM
Q65TY2, DAPB_MANSMC6BTW9, DAPB_MARSDQ9S3W8, DAPB_MASLA
A6UUT2, DAPB_META3Q8THP0, DAPB_METACA7I854, DAPB_METB6
Q46DC3, DAPB_METBFQ12ZG1, DAPB_METBUQ607A7, DAPB_METCA
Q2FNQ9, DAPB_METHJQ57865, DAPB_METJAQ8TVG7, DAPB_METKA
A2SQU7, DAPB_METLZA4FXV6, DAPB_METM5A9AB21, DAPB_METM6
A6VFL4, DAPB_METM7Q8PXL6, DAPB_METMAA3CVI6, DAPB_METMJ
Q6LYR5, DAPB_METMPA5ULF7, DAPB_METS3B8EIQ3, DAPB_METSB
Q2NHW0, DAPB_METSTO26891, DAPB_METTHA6UNQ4, DAPB_METVS
Q2RJL2, DAPB_MOOTAQ7TXX0, DAPB_MYCBOA1KMB5, DAPB_MYCBP
C1AFN6, DAPB_MYCBTA4TCI6, DAPB_MYCGIB2HKW6, DAPB_MYCMM
Q73VY3, DAPB_MYCPAA0QVR3, DAPB_MYCS2A3PYA0, DAPB_MYCSJ
A1UEU3, DAPB_MYCSKQ1BA69, DAPB_MYCSSA5U6C6, DAPB_MYCTA
P9WP22, DAPB_MYCTOP9WP23, DAPB_MYCTUA0PQF8, DAPB_MYCUA
A1T7N8, DAPB_MYCVPQ1CZV9, DAPB_MYXXDQ3ISP9, DAPB_NATPD
Q5F5Y7, DAPB_NEIG1B4RR35, DAPB_NEIG2A9M3H7, DAPB_NEIM0
Q9JX48, DAPB_NEIMAQ9K1F1, DAPB_NEIMBA1KRN3, DAPB_NEIMF
Q0AER1, DAPB_NITECQ82WP9, DAPB_NITEUQ2YBT6, DAPB_NITMU
Q3J7E0, DAPB_NITOCA6Q596, DAPB_NITSBQ3SW72, DAPB_NITWN
Q5YSW2, DAPB_NOCFAB2J0A9, DAPB_NOSP7Q8YU19, DAPB_NOSS1
Q8EQD3, DAPB_OCEIHQ30ZK7, DAPB_OLEA2A7HZ36, DAPB_PARL1
Q7U807, DAPB_PARMWB2JGX9, DAPB_PARP8P57867, DAPB_PASMU
Q6D0C7, DAPB_PECASC6DF00, DAPB_PECCPB4SEU9, DAPB_PELPB
A1ATI7, DAPB_PELPDQ4FNQ1, DAPB_PELUBQ7N8W3, DAPB_PHOLL
Q6LUK7, DAPB_PHOPRB1XT71, DAPB_POLNSQ7VC38, DAPB_PROMA
B4F2T9, DAPB_PROMHQ7V7D4, DAPB_PROMMQ7V1N1, DAPB_PROMP
Q46KV7, DAPB_PROMTQ48E64, DAPB_PSE14Q15TQ4, DAPB_PSEA6
A6VCL6, DAPB_PSEA7B7V1H1, DAPB_PSEA8Q02FR3, DAPB_PSEAB
P38103, DAPB_PSEAEQ52419, DAPB_PSEAJQ1IF57, DAPB_PSEE4
Q4KIG9, DAPB_PSEF5Q84CP9, DAPB_PSEFSA4XYF4, DAPB_PSEMY
A5W9A1, DAPB_PSEP1Q3KI98, DAPB_PSEPFB0KIS3, DAPB_PSEPG
Q88DU4, DAPB_PSEPKB1J256, DAPB_PSEPWQ87WP2, DAPB_PSESM
Q3IKQ7, DAPB_PSET1Q4ZNP9, DAPB_PSEU2A4VPQ3, DAPB_PSEU5
Q4FVQ6, DAPB_PSYA2B2UCA2, DAPB_RALPJQ8XVT2, DAPB_RALSO
P58326, DAPB_RHIMEO69783, DAPB_RHIMLQ7UJD7, DAPB_RHOBA
Q2J314, DAPB_RHOP2Q07UT2, DAPB_RHOP5Q6NCX8, DAPB_RHOPA
Q21CH6, DAPB_RHOPBQ13E66, DAPB_RHOPSB3Q978, DAPB_RHOPT
C3PMI6, DAPB_RICAEA8GMB6, DAPB_RICAHA8GV42, DAPB_RICB8
Q1RHE5, DAPB_RICBRA8EXL6, DAPB_RICCKQ92J79, DAPB_RICCN
Q4UKE7, DAPB_RICFEQ9ZE14, DAPB_RICPRC4K0R8, DAPB_RICPU
A8GQX3, DAPB_RICRSQ68XM0, DAPB_RICTYB7JW41, DAPB_RIPO1
Q16CE5, DAPB_ROSDOQ1AZV2, DAPB_RUBXDQ5LLT7, DAPB_RUEPO
Q1GKJ6, DAPB_RUESTQ21H39, DAPB_SACD2B5F744, DAPB_SALA4
A9MR41, DAPB_SALARQ57TJ7, DAPB_SALCHB5FHF8, DAPB_SALDC
B5R1Q4, DAPB_SALEPB5RG99, DAPB_SALG2B4TIG4, DAPB_SALHS
B4T6J1, DAPB_SALNSQ5PIL9, DAPB_SALPAA9MYI6, DAPB_SALPB
C0Q4K5, DAPB_SALPCB5BL41, DAPB_SALPKB4TWQ6, DAPB_SALSV
Q8Z9L9, DAPB_SALTIQ8ZRX8, DAPB_SALTYA8G9M8, DAPB_SERP5
A1S8K1, DAPB_SHEAMB8E4S9, DAPB_SHEB2A3D7S3, DAPB_SHEB5
A6WRU0, DAPB_SHEB8A9L0Q8, DAPB_SHEB9Q12QJ4, DAPB_SHEDO
Q086I8, DAPB_SHEFNB0TQB8, DAPB_SHEHHA3QGV8, DAPB_SHELP
Q8EHS7, DAPB_SHEONA8H756, DAPB_SHEPAA4Y9M3, DAPB_SHEPC
B8CKF7, DAPB_SHEPWA0KTT2, DAPB_SHESAA8FYT6, DAPB_SHESH
Q0HLM3, DAPB_SHESMQ0HY04, DAPB_SHESRA1RGQ6, DAPB_SHESW
B1KRS8, DAPB_SHEWMB2U250, DAPB_SHIB3Q326J2, DAPB_SHIBS
Q32K66, DAPB_SHIDSQ83SQ9, DAPB_SHIFLQ3Z5X9, DAPB_SHISS
C3MBY7, DAPB_SINFNA6UEW2, DAPB_SINMWQ2NVY2, DAPB_SODGM
A7X273, DAPB_STAA1A6U1L7, DAPB_STAA2Q2FH42, DAPB_STAA3
Q9EZ11, DAPB_STAA8A5ISS8, DAPB_STAA9Q2YXX3, DAPB_STAAB
Q5HG24, DAPB_STAACA6QGU7, DAPB_STAAEP63893, DAPB_STAAM
P63894, DAPB_STAANQ6GH12, DAPB_STAARQ6G9G5, DAPB_STAAS
A8Z3X4, DAPB_STAATQ8NWS4, DAPB_STAAWB9DP24, DAPB_STACT
Q5HPE6, DAPB_STAEQQ8CP95, DAPB_STAESQ4L6A1, DAPB_STAHJ
Q49XJ8, DAPB_STAS1Q82K82, DAPB_STRAWO86836, DAPB_STRCO
A8AX95, DAPB_STRGCB1VXZ4, DAPB_STRGGB4SHT7, DAPB_STRM5
B2FQ70, DAPB_STRMKQ8DUL9, DAPB_STRMUQ04JJ1, DAPB_STRP2
B5E6K0, DAPB_STRP4C1C8E8, DAPB_STRP7B1ICX7, DAPB_STRPI
B8ZLL9, DAPB_STRPJP63895, DAPB_STRPNB2IR75, DAPB_STRPS
P63896, DAPB_STRR6A4W0U7, DAPB_STRS2A3CMU3, DAPB_STRSV
A4VUK5, DAPB_STRSYQ5M154, DAPB_STRT1Q5M5P2, DAPB_STRT2
Q03M29, DAPB_STRTDB9DRX8, DAPB_STRU0C1CFE0, DAPB_STRZJ
C1CLQ6, DAPB_STRZPC1CSH7, DAPB_STRZTQ30PD7, DAPB_SULDN
A6Q6T6, DAPB_SULNBQ67P64, DAPB_SYMTHQ2LTA0, DAPB_SYNAS
Q3A1U6, DAPB_SYNC1Q31LA3, DAPB_SYNE7A0LEA6, DAPB_SYNFM
B1XIL4, DAPB_SYNP2Q5N0M4, DAPB_SYNP6A5GSL5, DAPB_SYNR3
Q3AYN5, DAPB_SYNS9Q3AIK8, DAPB_SYNSCQ0AXH2, DAPB_SYNWW
P72642, DAPB_SYNY3C5BQ31, DAPB_TERTTB7IF14, DAPB_THEAB
Q47RU3, DAPB_THEFYA6LP59, DAPB_THEM4Q9X1K8, DAPB_THEMA
B9K866, DAPB_THENNA5IM63, DAPB_THEP1B9KY70, DAPB_THERP
B1LBR0, DAPB_THESQQ8DHH2, DAPB_THEVBQ3SJS2, DAPB_THIDA
B8GNX3, DAPB_THISHC4LCT8, DAPB_TOLATQ10YI1, DAPB_TRIEI
B3E935, DAPB_TRIL1Q3MFY8, DAPB_TRIV2B7VJ13, DAPB_VIBA3
A7MXR0, DAPB_VIBC1A5F5N9, DAPB_VIBC3Q9KPH7, DAPB_VIBCH
C3LQT6, DAPB_VIBCMQ87SF5, DAPB_VIBPAQ8DEM0, DAPB_VIBVU
Q7MNU2, DAPB_VIBVYQ8D3H6, DAPB_WIGBRQ73I13, DAPB_WOLPM
B3CN84, DAPB_WOLPPQ7MA63, DAPB_WOLSUQ5GTA6, DAPB_WOLTR
C0R2S2, DAPB_WOLWRQ8PLE0, DAPB_XANACQ3BUC6, DAPB_XANC5
Q4UU71, DAPB_XANC8B0RSP5, DAPB_XANCBQ8P9L3, DAPB_XANCP
B2I841, DAPB_XYLF2Q9PEC3, DAPB_XYLFAB0U565, DAPB_XYLFM
Q87EC0, DAPB_XYLFTA1JJE5, DAPB_YERE8A7FMD2, DAPB_YERP3
Q1C0I8, DAPB_YERPAB2K3N1, DAPB_YERPBQ8ZIL6, DAPB_YERPE
A9R003, DAPB_YERPGQ1CMU5, DAPB_YERPNA4TQE9, DAPB_YERPP
Q66ER9, DAPB_YERPSB1JKZ4, DAPB_YERPYQ5NPM9, DAPB_ZYMMO

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