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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.17.2.1

Accepted Name
Nicotinate dehydrogenase (cytochrome).
Alternative Name(s)
Nicotinate hydroxylase.
Nicotinic acid hydroxylase.
Reaction catalysed
Nicotinate + a ferricytochrome + H(2)O <=> 6-hydroxynicotinate + a ferrocytochrome + 2 H(+)
Cofactor(s)
Iron-sulfur; Molybdopterin cytosine dinucleotide.
Comment(s)
  • This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family.
  • While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase.
Cross-references
BRENDA1.17.2.1
EC2PDB1.17.2.1
ExplorEnz1.17.2.1
PRIAM enzyme-specific profiles1.17.2.1
KEGG Ligand Database for Enzyme Nomenclature1.17.2.1
IUBMB Enzyme Nomenclature1.17.2.1
IntEnz1.17.2.1
MEDLINEFind literature relating to 1.17.2.1
MetaCyc1.17.2.1
UniProtKB/Swiss-Prot
Q88FX9, NICA_PSEPK;  Q88FX8, NICB_PSEPK;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
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