ID   1.17.4.4
DE   vitamin-K-epoxide reductase (warfarin-sensitive).
AN   phylloquinone epoxide reductase.
AN   vitamin K1 epoxide reductase.
CA   (1) [protein]-disulfide + H2O + phylloquinone = 2,3-epoxyphylloquinone +
CA   [protein]-dithiol.
CA   (2) [protein]-disulfide + phylloquinol = [protein]-dithiol +
CA   phylloquinone.
CC   -!- The enzyme catalyzes the reduction of vitamin K 2,3-epoxide, which is
CC       formed by the activity of EC 4.1.1.90, back to its phylloquinol
CC       active form.
CC   -!- The enzyme forms a tight complex with EC 5.3.4.1, which transfers the
CC       required electrons from newly-synthesized proteins by catalyzing the
CC       formation of disulfide bridges.
CC   -!- The enzyme acts on the epoxide forms of both phylloquinone (vitamin
CC       K1) and menaquinone (vitamin K2).
CC   -!- Inhibited strongly by (S)-warfarin and ferulenol.
CC   -!- Formerly EC 1.1.4.1.
DR   Q6B4J2, VKOR1_BOVIN;  Q9BQB6, VKOR1_HUMAN;  Q9CRC0, VKOR1_MOUSE;
DR   Q6TEK4, VKOR1_RAT  ;  Q8N0U8, VKORL_HUMAN;  Q6TEK5, VKORL_MOUSE;
DR   Q6TEK3, VKORL_RAT  ;  Q6TEK8, VKORL_TAKRU;
//