ID 1.17.4.5 DE vitamin-K-epoxide reductase (warfarin-insensitive). AN vitamin K 2,3-epoxide reductase. CA 3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized CA dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone. CC -!- Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) CC vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide. CC -!- Not inhibited by warfarin (cf. EC 1.17.4.4). CC -!- Formerly EC 1.1.4.2. //