ID   1.17.7.3
DE   (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
AN   (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase.
AN   4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase.
CA   (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized
CA   [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced
CA   [flavodoxin].
CC   -!- Forms part of an alternative non-mevalonate pathway for isoprenoid
CC       biosynthesis that is found in most bacteria.
CC   -!- Plants and cyanobacteria have a similar enzyme that utilizes
CC       ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).
DR   Q82K43, ISPG1_STRAW;  Q9X7W2, ISPG1_STRCO;  Q82ML3, ISPG2_STRAW;
DR   Q9KYR9, ISPG2_STRCO;  Q6FEM3, ISPG_ACIAD ;  B7H069, ISPG_ACIB3 ;
DR   B7I5G7, ISPG_ACIB5 ;  B2I3E5, ISPG_ACIBC ;  B0VKR8, ISPG_ACIBS ;
DR   A3M211, ISPG_ACIBT ;  B0V5G7, ISPG_ACIBY ;  A0LV34, ISPG_ACIC1 ;
DR   A5FX97, ISPG_ACICJ ;  B7JC30, ISPG_ACIF2 ;  B5EJF3, ISPG_ACIF5 ;
DR   A3N1H8, ISPG_ACTP2 ;  B3GY64, ISPG_ACTP7 ;  B0BQB9, ISPG_ACTPJ ;
DR   A6VQX6, ISPG_ACTSZ ;  B6JA27, ISPG_AFIC5 ;  P58665, ISPG_AGRFC ;
DR   B2UKT9, ISPG_AKKM8 ;  Q0VNE0, ISPG_ALCBS ;  Q5E772, ISPG_ALIF1 ;
DR   B5FAX2, ISPG_ALIFM ;  B6EGY7, ISPG_ALISL ;  B9JV07, ISPG_ALLAM ;
DR   B4RV89, ISPG_ALTMD ;  Q5PAJ1, ISPG_ANAMM ;  B7GH89, ISPG_ANOFW ;
DR   O67496, ISPG_AQUAE ;  Q5P7B3, ISPG_AROAE ;  A0JUS8, ISPG_ARTS2 ;
DR   C1DE57, ISPG_AZOVD ;  C3P8I5, ISPG_BACAA ;  C3LKV7, ISPG_BACAC ;
DR   A0RIQ2, ISPG_BACAH ;  Q81LV7, ISPG_BACAN ;  B7JN03, ISPG_BACC0 ;
DR   Q730Q8, ISPG_BACC1 ;  B7IYD0, ISPG_BACC2 ;  C1ES01, ISPG_BACC3 ;
DR   B7HCQ3, ISPG_BACC4 ;  B7HPH8, ISPG_BACC7 ;  A7GSX5, ISPG_BACCN ;
DR   B9IY45, ISPG_BACCQ ;  Q818H8, ISPG_BACCR ;  Q634Q9, ISPG_BACCZ ;
DR   Q5L7W2, ISPG_BACFN ;  Q64N34, ISPG_BACFR ;  Q6HDN9, ISPG_BACHK ;
DR   Q65HA9, ISPG_BACLD ;  A9VH61, ISPG_BACMK ;  A8FF87, ISPG_BACP2 ;
DR   P54482, ISPG_BACSU ;  Q8A4T0, ISPG_BACTN ;  A7Z6S2, ISPG_BACVZ ;
DR   A1UR54, ISPG_BARBK ;  Q6G1X4, ISPG_BARHE ;  Q6G104, ISPG_BARQU ;
DR   A9IYW1, ISPG_BART1 ;  Q1LU77, ISPG_BAUCH ;  B2IE63, ISPG_BEII9 ;
DR   Q8G7Y6, ISPG_BIFLO ;  Q492E0, ISPG_BLOPB ;  Q7WHN0, ISPG_BORBR ;
DR   Q7W6P6, ISPG_BORPA ;  Q7VWL0, ISPG_BORPE ;  Q89VV9, ISPG_BRADU ;
DR   A5ETI5, ISPG_BRASB ;  A4YKQ8, ISPG_BRASO ;  C0ZF58, ISPG_BREBN ;
DR   B2S7K6, ISPG_BRUA1 ;  Q2YLG4, ISPG_BRUA2 ;  A6WXY9, ISPG_BRUA4 ;
DR   Q57BA5, ISPG_BRUAB ;  A9M820, ISPG_BRUC2 ;  C0RF32, ISPG_BRUMB ;
DR   Q8YJ17, ISPG_BRUME ;  A9WWQ2, ISPG_BRUSI ;  Q8FYT2, ISPG_BRUSU ;
DR   P57374, ISPG_BUCAI ;  Q8K9P4, ISPG_BUCAP ;  B1YR44, ISPG_BURA4 ;
DR   B4EAW9, ISPG_BURCJ ;  A3MK75, ISPG_BURM7 ;  A2S2A2, ISPG_BURM9 ;
DR   Q62JW4, ISPG_BURMA ;  A1V4K1, ISPG_BURMS ;  A3NVX1, ISPG_BURP0 ;
DR   Q3JRQ3, ISPG_BURP1 ;  A3NA54, ISPG_BURP6 ;  Q63UT3, ISPG_BURPS ;
DR   Q8RA30, ISPG_CALS4 ;  A4XLZ4, ISPG_CALS8 ;  A7ZCT9, ISPG_CAMC1 ;
DR   A7GZ54, ISPG_CAMC5 ;  A0RPL8, ISPG_CAMFF ;  A8FLB6, ISPG_CAMJ8 ;
DR   A7H4D8, ISPG_CAMJD ;  Q9PPM1, ISPG_CAMJE ;  A1VZ41, ISPG_CAMJJ ;
DR   Q5HV95, ISPG_CAMJR ;  B9KD64, ISPG_CAMLR ;  Q9A9W0, ISPG_CAUVC ;
DR   B3PDM1, ISPG_CELJU ;  Q5L669, ISPG_CHLAB ;  Q823I7, ISPG_CHLCV ;
DR   Q254D2, ISPG_CHLFF ;  Q9PKY3, ISPG_CHLMU ;  Q9Z8H0, ISPG_CHLPN ;
DR   B0B9G5, ISPG_CHLT2 ;  Q3KMW4, ISPG_CHLTA ;  B0BB44, ISPG_CHLTB ;
DR   Q8KG23, ISPG_CHLTE ;  O84060, ISPG_CHLTR ;  Q1QTK8, ISPG_CHRSD ;
DR   Q7NS88, ISPG_CHRVO ;  A8AD71, ISPG_CITK8 ;  A5CT01, ISPG_CLAM3 ;
DR   B0RDZ5, ISPG_CLAMS ;  Q97I56, ISPG_CLOAB ;  P58667, ISPG_CLOPE ;
DR   Q895K3, ISPG_CLOTE ;  Q47WC0, ISPG_COLP3 ;  Q6NGL3, ISPG_CORDI ;
DR   Q8FP82, ISPG_COREF ;  Q8NP12, ISPG_CORGL ;  Q4JV28, ISPG_CORJK ;
DR   B1VGA4, ISPG_CORU7 ;  A7MGV7, ISPG_CROS8 ;  Q6A7L2, ISPG_CUTAK ;
DR   Q47BR6, ISPG_DECAR ;  A5FS85, ISPG_DEHMB ;  Q3ZZC9, ISPG_DEHMC ;
DR   Q9RXC9, ISPG_DEIRA ;  Q6AP32, ISPG_DESPS ;  Q72CD9, ISPG_DESVH ;
DR   A8LI72, ISPG_DINSH ;  A7ZPV8, ISPG_ECO24 ;  B7UGW1, ISPG_ECO27 ;
DR   B7MI00, ISPG_ECO45 ;  B7LDA7, ISPG_ECO55 ;  P62622, ISPG_ECO57 ;
DR   B5Z0Y4, ISPG_ECO5E ;  B7NRG5, ISPG_ECO7I ;  B7MYF0, ISPG_ECO81 ;
DR   B7M7L9, ISPG_ECO8A ;  C4ZX90, ISPG_ECOBW ;  B1XAZ0, ISPG_ECODH ;
DR   A8A321, ISPG_ECOHS ;  A1AE53, ISPG_ECOK1 ;  Q0TEX0, ISPG_ECOL5 ;
DR   P62621, ISPG_ECOL6 ;  B1IWE6, ISPG_ECOLC ;  P62620, ISPG_ECOLI ;
DR   B7N6A3, ISPG_ECOLU ;  B6I587, ISPG_ECOSE ;  B1LNH0, ISPG_ECOSM ;
DR   Q1R8L8, ISPG_ECOUT ;  Q3YRZ7, ISPG_EHRCJ ;  Q5FHA6, ISPG_EHRRG ;
DR   Q5HB57, ISPG_EHRRW ;  A4WD93, ISPG_ENT38 ;  B2VE89, ISPG_ERWT9 ;
DR   B7LKC3, ISPG_ESCF3 ;  B1YLA2, ISPG_EXIS2 ;  C4L3K5, ISPG_EXISA ;
DR   Q0RDR2, ISPG_FRAAA ;  Q2J717, ISPG_FRACC ;  A8L6E2, ISPG_FRASN ;
DR   Q14IL6, ISPG_FRAT1 ;  B2SG03, ISPG_FRATM ;  A0Q6U8, ISPG_FRATN ;
DR   Q0BMA6, ISPG_FRATO ;  Q5NH64, ISPG_FRATT ;  Q8RG40, ISPG_FUSNN ;
DR   Q5KX35, ISPG_GEOKA ;  Q74D60, ISPG_GEOSL ;  C5D4Q3, ISPG_GEOSW ;
DR   A4IQZ4, ISPG_GEOTN ;  A9HJ48, ISPG_GLUDA ;  Q5FUR7, ISPG_GLUOX ;
DR   Q0BUK0, ISPG_GRABC ;  Q7VME2, ISPG_HAEDU ;  Q4QNH4, ISPG_HAEI8 ;
DR   A5UAB9, ISPG_HAEIE ;  A5UGH1, ISPG_HAEIG ;  P44667, ISPG_HAEIN ;
DR   Q2SDW4, ISPG_HAHCH ;  Q9KD18, ISPG_HALH5 ;  C4K4I8, ISPG_HAMD5 ;
DR   Q17XU2, ISPG_HELAH ;  Q7VI04, ISPG_HELHP ;  B6JLL3, ISPG_HELP2 ;
DR   B5Z6Z7, ISPG_HELPG ;  Q1CTP7, ISPG_HELPH ;  Q9ZLL0, ISPG_HELPJ ;
DR   B2UTK0, ISPG_HELPS ;  O25342, ISPG_HELPY ;  Q0I2E9, ISPG_HISS1 ;
DR   B0USG8, ISPG_HISS2 ;  B4U9V3, ISPG_HYDS0 ;  Q0C4J3, ISPG_HYPNA ;
DR   Q5QYA9, ISPG_IDILO ;  Q28R10, ISPG_JANSC ;  B5XNL5, ISPG_KLEP3 ;
DR   A6TCD4, ISPG_KLEP7 ;  B2GKS3, ISPG_KOCRD ;  Q1IRS5, ISPG_KORVE ;
DR   C1DD43, ISPG_LARHH ;  Q1MSE5, ISPG_LAWIP ;  Q6AEX9, ISPG_LEIXX ;
DR   Q04UL2, ISPG_LEPBJ ;  Q04YW2, ISPG_LEPBL ;  Q72TR2, ISPG_LEPIC ;
DR   Q8F1H5, ISPG_LEPIN ;  C1L2Z7, ISPG_LISMC ;  Q71ZM9, ISPG_LISMF ;
DR   P58668, ISPG_LISMO ;  B1HSS4, ISPG_LYSSC ;  B9E6U1, ISPG_MACCJ ;
DR   A0LDN3, ISPG_MAGMM ;  Q8EUI6, ISPG_MALP2 ;  Q65R84, ISPG_MANSM ;
DR   A6VV06, ISPG_MARMS ;  A1TZQ0, ISPG_MARN8 ;  C6BYK9, ISPG_MARSD ;
DR   Q604Q5, ISPG_METCA ;  Q1H0U9, ISPG_METFK ;  Q7TXN6, ISPG_MYCBO ;
DR   A1KML3, ISPG_MYCBP ;  C1AFY4, ISPG_MYCBT ;  Q7NBH3, ISPG_MYCGA ;
DR   B8ZRU5, ISPG_MYCLB ;  Q9CBU5, ISPG_MYCLE ;  Q73VS3, ISPG_MYCPA ;
DR   A5U6M2, ISPG_MYCTA ;  P9WKG2, ISPG_MYCTO ;  P9WKG3, ISPG_MYCTU ;
DR   B2A390, ISPG_NATTJ ;  B9LA27, ISPG_NAUPA ;  Q5F913, ISPG_NEIG1 ;
DR   B4RMG4, ISPG_NEIG2 ;  A9LZN8, ISPG_NEIM0 ;  Q9JU34, ISPG_NEIMA ;
DR   Q9JZ40, ISPG_NEIMB ;  A1KUD8, ISPG_NEIMF ;  Q0AE42, ISPG_NITEC ;
DR   Q82XV0, ISPG_NITEU ;  Q1QQI9, ISPG_NITHX ;  A6Q1U2, ISPG_NITSB ;
DR   Q3SVD0, ISPG_NITWN ;  Q5YS74, ISPG_NOCFA ;  A1R501, ISPG_PAEAT ;
DR   A6LGR5, ISPG_PARD8 ;  A1B323, ISPG_PARDP ;  Q6MD85, ISPG_PARUW ;
DR   P57987, ISPG_PASMU ;  Q6D276, ISPG_PECAS ;  C6DBH4, ISPG_PECCP ;
DR   Q4FNA0, ISPG_PELUB ;  C0QRI5, ISPG_PERMH ;  Q7N706, ISPG_PHOLL ;
DR   Q6LU49, ISPG_PHOPR ;  A6L089, ISPG_PHOV8 ;  Q7MVT7, ISPG_PORGI ;
DR   B4EZT3, ISPG_PROMH ;  P72241, ISPG_PROST ;  Q48LZ4, ISPG_PSE14 ;
DR   A6V0W0, ISPG_PSEA7 ;  B7UWI8, ISPG_PSEA8 ;  Q02RV7, ISPG_PSEAB ;
DR   Q9HXJ4, ISPG_PSEAE ;  B8HG44, ISPG_PSECP ;  Q1IEI1, ISPG_PSEE4 ;
DR   Q4K6U9, ISPG_PSEF5 ;  C3K1L4, ISPG_PSEFS ;  A8F4Y8, ISPG_PSELT ;
DR   A4XY32, ISPG_PSEMY ;  A5VYT5, ISPG_PSEP1 ;  Q3K7B6, ISPG_PSEPF ;
DR   B0KPI7, ISPG_PSEPG ;  Q88PJ7, ISPG_PSEPK ;  B1JDV8, ISPG_PSEPW ;
DR   Q886Z0, ISPG_PSESM ;  Q3ICZ5, ISPG_PSET1 ;  Q4ZX23, ISPG_PSEU2 ;
DR   Q4FTW7, ISPG_PSYA2 ;  Q1QD18, ISPG_PSYCK ;  A1SU39, ISPG_PSYIN ;
DR   P58669, ISPG_RALN1 ;  B2U9U9, ISPG_RALPJ ;  A9WR14, ISPG_RENSM ;
DR   B3PR71, ISPG_RHIE6 ;  Q2K333, ISPG_RHIEC ;  Q1MAC5, ISPG_RHIJ3 ;
DR   Q98FG0, ISPG_RHILO ;  B5ZUA0, ISPG_RHILW ;  Q92L19, ISPG_RHIME ;
DR   B9JE02, ISPG_RHIR8 ;  Q7UWC8, ISPG_RHOBA ;  C1B2V4, ISPG_RHOOB ;
DR   Q2J2S7, ISPG_RHOP2 ;  Q07V91, ISPG_RHOP5 ;  Q6NCF3, ISPG_RHOPA ;
DR   Q21C20, ISPG_RHOPB ;  B3QBC6, ISPG_RHOPT ;  Q2RWE4, ISPG_RHORT ;
DR   Q5LQ99, ISPG_RUEPO ;  Q1GIC1, ISPG_RUEST ;  B8I6E1, ISPG_RUMCH ;
DR   A1AW46, ISPG_RUTMC ;  Q21KT3, ISPG_SACD2 ;  B5F198, ISPG_SALA4 ;
DR   A8M723, ISPG_SALAI ;  A9MHL5, ISPG_SALAR ;  Q57LI6, ISPG_SALCH ;
DR   B5FR63, ISPG_SALDC ;  B5R582, ISPG_SALEP ;  B5RCZ2, ISPG_SALG2 ;
DR   B4TD93, ISPG_SALHS ;  B4T0P9, ISPG_SALNS ;  Q5PNI2, ISPG_SALPA ;
DR   A9N201, ISPG_SALPB ;  B5BAY5, ISPG_SALPK ;  B4TR95, ISPG_SALSV ;
DR   P58670, ISPG_SALTI ;  A4X4L9, ISPG_SALTO ;  P58671, ISPG_SALTY ;
DR   A8GHW5, ISPG_SERP5 ;  A1S863, ISPG_SHEAM ;  B8E9S7, ISPG_SHEB2 ;
DR   A3D6V9, ISPG_SHEB5 ;  A6WQP7, ISPG_SHEB8 ;  A9KXK8, ISPG_SHEB9 ;
DR   Q12PT4, ISPG_SHEDO ;  Q085U6, ISPG_SHEFN ;  B0TLI4, ISPG_SHEHH ;
DR   A3QCG2, ISPG_SHELP ;  Q8EC32, ISPG_SHEON ;  A8H245, ISPG_SHEPA ;
DR   A4Y8U0, ISPG_SHEPC ;  B8CKR1, ISPG_SHEPW ;  A0KUJ5, ISPG_SHESA ;
DR   A8FT70, ISPG_SHESH ;  Q0HKV9, ISPG_SHESM ;  Q0HX57, ISPG_SHESR ;
DR   A1RHQ3, ISPG_SHESW ;  B1KKJ2, ISPG_SHEWM ;  B2TXU0, ISPG_SHIB3 ;
DR   Q31XX5, ISPG_SHIBS ;  Q32D47, ISPG_SHIDS ;  Q0T204, ISPG_SHIF8 ;
DR   Q83K43, ISPG_SHIFL ;  Q3YZ37, ISPG_SHISS ;  Q5WHB2, ISPG_SHOC1 ;
DR   C3MAL6, ISPG_SINFN ;  A6UE79, ISPG_SINMW ;  Q2NS40, ISPG_SODGM ;
DR   Q029T9, ISPG_SOLUE ;  B1VYP5, ISPG_STRGG ;  B4SRZ0, ISPG_STRM5 ;
DR   B2FL74, ISPG_STRMK ;  Q30TM4, ISPG_SULDN ;  A6QC65, ISPG_SULNB ;
DR   B2V7Y2, ISPG_SULSY ;  Q67PA7, ISPG_SYMTH ;  B7IFY1, ISPG_THEAB ;
DR   Q47RY0, ISPG_THEFY ;  Q9WZZ3, ISPG_THEMA ;  A5IIP2, ISPG_THEP1 ;
DR   B1LC43, ISPG_THESQ ;  Q72H18, ISPG_THET2 ;  Q5SLI8, ISPG_THET8 ;
DR   Q84GJ3, ISPG_THETH ;  B5YIQ4, ISPG_THEYD ;  Q73N90, ISPG_TREDE ;
DR   O83460, ISPG_TREPA ;  Q83NE4, ISPG_TROW8 ;  Q83N18, ISPG_TROWT ;
DR   A5CX35, ISPG_VESOH ;  B7VJT8, ISPG_VIBA3 ;  A7MU42, ISPG_VIBC1 ;
DR   Q9KTX1, ISPG_VIBCH ;  Q87S16, ISPG_VIBPA ;  Q8DEZ8, ISPG_VIBVU ;
DR   Q7MNF1, ISPG_VIBVY ;  Q8D1Y3, ISPG_WIGBR ;  Q73IP1, ISPG_WOLPM ;
DR   B3CNN4, ISPG_WOLPP ;  Q7M8Z2, ISPG_WOLSU ;  Q5GRK4, ISPG_WOLTR ;
DR   C0R5E5, ISPG_WOLWR ;  Q8PLJ8, ISPG_XANAC ;  Q3BUK3, ISPG_XANC5 ;
DR   Q4UTW8, ISPG_XANC8 ;  B0RTS9, ISPG_XANCB ;  Q8P9R7, ISPG_XANCP ;
DR   Q2P3M7, ISPG_XANOM ;  Q5H0N8, ISPG_XANOR ;  Q9PAE3, ISPG_XYLFA ;
DR   Q87A73, ISPG_XYLFT ;  A1JKS2, ISPG_YERE8 ;  A7FFY9, ISPG_YERP3 ;
DR   Q1C5I8, ISPG_YERPA ;  B2K9Q0, ISPG_YERPB ;  P58672, ISPG_YERPE ;
DR   A9R802, ISPG_YERPG ;  Q1CK91, ISPG_YERPN ;  A4TMT7, ISPG_YERPP ;
DR   Q667Z9, ISPG_YERPS ;  B1JS05, ISPG_YERPY ;  Q5NR50, ISPG_ZYMMO ;
//