ID 1.17.7.4 DE 4-hydroxy-3-methylbut-2-enyl diphosphate reductase. AN (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase. AN HMBPP reductase. CA (1) H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = CA (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe- CA 2S]-[ferredoxin]. CA (2) dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CA (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe- CA 2S]-[ferredoxin]. CC -!- Forms a system with a ferredoxin or a flavodoxin and an CC NAD(P)H-dependent reductase. CC -!- This is the last enzyme in the non-mevalonate pathway for isoprenoid CC biosynthesis. CC -!- This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) CC or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found CC in most bacteria and in plant chloroplasts. CC -!- The enzyme acts in the reverse direction, producing a 5:1 mixture of CC isopentenyl diphosphate and prenyl diphosphate. CC -!- Formerly EC 1.17.1.2. DR Q89UU5, ISPH1_BRADU; Q629Z7, ISPH1_BURMA; Q63WH0, ISPH1_BURPS; DR P0A5I1, ISPH1_MYCBO; P9WKF8, ISPH1_MYCTO; P9WKF9, ISPH1_MYCTU; DR Q6N3G0, ISPH1_RHOPA; Q89QW7, ISPH2_BRADU; Q62HM8, ISPH2_BURMA; DR P0DMK8, ISPH2_BURPS; P0A5I3, ISPH2_MYCBO; P9WKG0, ISPH2_MYCTO; DR P9WKG1, ISPH2_MYCTU; Q6N1Y1, ISPH2_RHOPA; B0C4N8, ISPH_ACAM1 ; DR Q9RBJ0, ISPH_ACIAD ; B7GVR1, ISPH_ACIB3 ; B7IAU0, ISPH_ACIB5 ; DR B2HZW3, ISPH_ACIBC ; B0VQ53, ISPH_ACIBS ; A3M9H2, ISPH_ACIBT ; DR B0V8K4, ISPH_ACIBY ; A0LW20, ISPH_ACIC1 ; B7JBD6, ISPH_ACIF2 ; DR B5ERJ7, ISPH_ACIF5 ; A3N2G8, ISPH_ACTP2 ; B3GYK1, ISPH_ACTP7 ; DR B0BRB3, ISPH_ACTPJ ; A6VQH8, ISPH_ACTSZ ; A0KG42, ISPH_AERHH ; DR A4SIX8, ISPH_AERS4 ; P58673, ISPH_AGRFC ; Q0VSD8, ISPH_ALCBS ; DR Q5E7N1, ISPH_ALIF1 ; B5FA63, ISPH_ALIFM ; B6ENC7, ISPH_ALISL ; DR A6TRF9, ISPH_ALKMQ ; A8MFE2, ISPH_ALKOO ; A7HCQ8, ISPH_ANADF ; DR B9KIX9, ISPH_ANAMF ; Q5PAE7, ISPH_ANAMM ; B4UEK4, ISPH_ANASK ; DR B7GH78, ISPH_ANOFW ; O67625, ISPH_AQUAE ; Q94B35, ISPH_ARATH ; DR Q5P224, ISPH_AROAE ; B6YQB8, ISPH_AZOPC ; A1K4R4, ISPH_AZOSB ; DR C1DPH8, ISPH_AZOVD ; C3P8J4, ISPH_BACAA ; C3LKW7, ISPH_BACAC ; DR A0RIR1, ISPH_BACAH ; Q81LU9, ISPH_BACAN ; B7JN13, ISPH_BACC0 ; DR Q730P8, ISPH_BACC1 ; B7IYD9, ISPH_BACC2 ; C1ESI2, ISPH_BACC3 ; DR B7HCR2, ISPH_BACC4 ; B7HPI8, ISPH_BACC7 ; A7GSY4, ISPH_BACCN ; DR B9IY56, ISPH_BACCQ ; Q634Q0, ISPH_BACCZ ; Q5L9K3, ISPH_BACFN ; DR Q64PU1, ISPH_BACFR ; Q6HDN0, ISPH_BACHK ; Q65H97, ISPH_BACLD ; DR A9VHR7, ISPH_BACMK ; A8FFA1, ISPH_BACP2 ; P54473, ISPH_BACSU ; DR Q8A625, ISPH_BACTN ; A7Z6T1, ISPH_BACVZ ; A1URX2, ISPH_BARBK ; DR Q6G4C5, ISPH_BARHE ; Q6G0C9, ISPH_BARQU ; A9IQQ9, ISPH_BART1 ; DR Q1LSS7, ISPH_BAUCH ; B2IED0, ISPH_BEII9 ; Q8G4L8, ISPH_BIFLO ; DR Q493S1, ISPH_BLOPB ; Q7WHF2, ISPH_BORBR ; Q7W9B4, ISPH_BORPA ; DR Q7VYS2, ISPH_BORPE ; A0A2Z5WA18, ISPH_BOTBR ; C0ZL73, ISPH_BREBN ; DR B2S9W9, ISPH_BRUA1 ; A6WWG6, ISPH_BRUA4 ; Q57EP6, ISPH_BRUAB ; DR Q8YFR1, ISPH_BRUME ; Q8G257, ISPH_BRUSU ; B8D8U8, ISPH_BUCA5 ; DR P57247, ISPH_BUCAI ; Q8K9Z4, ISPH_BUCAP ; B8D752, ISPH_BUCAT ; DR I1WW99, ISPH_BURP2 ; Q8RA76, ISPH_CALS4 ; A7ZCD0, ISPH_CAMC1 ; DR A7GXB5, ISPH_CAMC5 ; A0RQC4, ISPH_CAMFF ; A7I0N0, ISPH_CAMHC ; DR A8FLU3, ISPH_CAMJ8 ; A7H3F3, ISPH_CAMJD ; P0C632, ISPH_CAMJE ; DR A1VZM8, ISPH_CAMJJ ; Q5HUR4, ISPH_CAMJR ; B9KD74, ISPH_CAMLR ; DR Q9A345, ISPH_CAUVC ; A3PGE9, ISPH_CERS1 ; Q3J5X0, ISPH_CERS4 ; DR A4WVQ4, ISPH_CERS5 ; Q11KC7, ISPH_CHESB ; Q5L5D3, ISPH_CHLAB ; DR Q3AT23, ISPH_CHLCH ; Q822D9, ISPH_CHLCV ; Q255J4, ISPH_CHLFF ; DR B3EFF5, ISPH_CHLL2 ; Q3B241, ISPH_CHLL3 ; Q9PL59, ISPH_CHLMU ; DR B3QQE0, ISPH_CHLP8 ; B3EM42, ISPH_CHLPB ; A1BDJ5, ISPH_CHLPD ; DR A4SGC0, ISPH_CHLPM ; Q9Z6P2, ISPH_CHLPN ; B0B991, ISPH_CHLT2 ; DR B3QSU2, ISPH_CHLT3 ; Q3KKH8, ISPH_CHLTA ; B0BAX0, ISPH_CHLTB ; DR Q8KFN9, ISPH_CHLTE ; O84867, ISPH_CHLTR ; Q1R0B2, ISPH_CHRSD ; DR Q7NS59, ISPH_CHRVO ; B5E9S9, ISPH_CITBB ; A8ALT3, ISPH_CITK8 ; DR Q97I09, ISPH_CLOAB ; Q187C6, ISPH_CLOD6 ; Q0TRF3, ISPH_CLOP1 ; DR P58675, ISPH_CLOPE ; Q0STT3, ISPH_CLOPS ; Q895G2, ISPH_CLOTE ; DR Q486R1, ISPH_COLP3 ; Q6NI36, ISPH_CORDI ; Q8FQP0, ISPH_COREF ; DR A4QCY9, ISPH_CORGB ; Q8NRM2, ISPH_CORGL ; B1WTZ2, ISPH_CROS5 ; DR A7MIM0, ISPH_CROS8 ; Q6AA89, ISPH_CUTAK ; B8HWD3, ISPH_CYAP4 ; DR Q11YY5, ISPH_CYTH3 ; Q47BK8, ISPH_DECAR ; Q3Z6U4, ISPH_DEHM1 ; DR A5FPY7, ISPH_DEHMB ; Q3ZYL6, ISPH_DEHMC ; Q9RSG0, ISPH_DEIRA ; DR B8J3G9, ISPH_DESDA ; Q6AL80, ISPH_DESPS ; Q72G08, ISPH_DESVH ; DR B8DMK7, ISPH_DESVM ; A1VHK1, ISPH_DESVV ; B5YEC2, ISPH_DICT6 ; DR B8E2T7, ISPH_DICTD ; A8LLC7, ISPH_DINSH ; A7ZHB8, ISPH_ECO24 ; DR B7UI74, ISPH_ECO27 ; B7MAE9, ISPH_ECO45 ; B7L4F1, ISPH_ECO55 ; DR P62625, ISPH_ECO57 ; B5YYC1, ISPH_ECO5E ; B7NHD3, ISPH_ECO7I ; DR B7MNN4, ISPH_ECO81 ; B7M0C5, ISPH_ECO8A ; C4ZPV5, ISPH_ECOBW ; DR B1XBF4, ISPH_ECODH ; A7ZVX7, ISPH_ECOHS ; A1A777, ISPH_ECOK1 ; DR Q0TLW2, ISPH_ECOL5 ; P62624, ISPH_ECOL6 ; B1IRE6, ISPH_ECOLC ; DR P62623, ISPH_ECOLI ; B7N7Q3, ISPH_ECOLU ; B6HYX7, ISPH_ECOSE ; DR B1LFV9, ISPH_ECOSM ; Q1RGH3, ISPH_ECOUT ; C5B7M7, ISPH_EDWI9 ; DR Q5FFL5, ISPH_EHRRG ; Q5HB13, ISPH_EHRRW ; A4W6E4, ISPH_ENT38 ; DR B2VH04, ISPH_ERWT9 ; B7LVN5, ISPH_ESCF3 ; B1YL84, ISPH_EXIS2 ; DR C4L3Z5, ISPH_EXISA ; B0U064, ISPH_FRAP2 ; Q14I06, ISPH_FRAT1 ; DR A7NA22, ISPH_FRATF ; Q2A587, ISPH_FRATH ; B2SES8, ISPH_FRATM ; DR A0Q4T9, ISPH_FRATN ; Q0BNK1, ISPH_FRATO ; Q5NGK4, ISPH_FRATT ; DR A4IYW2, ISPH_FRATW ; Q8RI52, ISPH_FUSNN ; B9LZG4, ISPH_GEODF ; DR Q5KX24, ISPH_GEOKA ; Q39XB6, ISPH_GEOMG ; Q749Y8, ISPH_GEOSL ; DR C6E2B3, ISPH_GEOSM ; C5D4R3, ISPH_GEOSW ; A4IR05, ISPH_GEOTN ; DR A5GE10, ISPH_GEOUR ; B8F6E6, ISPH_GLAP5 ; B7KEG3, ISPH_GLOC7 ; DR Q7NG74, ISPH_GLOVI ; Q5FUH7, ISPH_GLUOX ; Q7VPK4, ISPH_HAEDU ; DR Q4QLQ5, ISPH_HAEI8 ; A5UD69, ISPH_HAEIE ; A5UID9, ISPH_HAEIG ; DR P44976, ISPH_HAEIN ; Q2S9U2, ISPH_HAHCH ; Q9KD37, ISPH_HALH5 ; DR C4K4R2, ISPH_HAMD5 ; Q7VJV5, ISPH_HELHP ; B6JMP4, ISPH_HELP2 ; DR Q1CSL3, ISPH_HELPH ; P65186, ISPH_HELPJ ; B2UUG0, ISPH_HELPS ; DR P65185, ISPH_HELPY ; B0UV08, ISPH_HISS2 ; Q0BYQ0, ISPH_HYPNA ; DR Q5QZR7, ISPH_IDILO ; B5Y232, ISPH_KLEP3 ; A6T4G3, ISPH_KLEP7 ; DR C5CIU9, ISPH_KOSOT ; Q6ADV0, ISPH_LEIXX ; Q72S57, ISPH_LEPIC ; DR Q8F3I3, ISPH_LEPIN ; C1KV98, ISPH_LISMC ; Q71ZL9, ISPH_LISMF ; DR P58676, ISPH_LISMO ; B1HTG5, ISPH_LYSSC ; B9E6U8, ISPH_MACCJ ; DR A0LD71, ISPH_MAGMM ; Q8EWR9, ISPH_MALP2 ; Q65RQ4, ISPH_MANSM ; DR A1TYZ2, ISPH_MARN8 ; Q607E5, ISPH_METCA ; A2SJA8, ISPH_METPP ; DR B8EQB9, ISPH_METSB ; B0JVA7, ISPH_MICAN ; A4T986, ISPH_MYCGI ; DR Q9X781, ISPH_MYCLE ; Q73WH6, ISPH_MYCPA ; A3Q4N0, ISPH_MYCSJ ; DR A1UKL5, ISPH_MYCSK ; Q1B4H4, ISPH_MYCSS ; A0PKQ3, ISPH_MYCUA ; DR A1TE06, ISPH_MYCVP ; B9L9K5, ISPH_NAUPA ; Q5FAF2, ISPH_NEIG1 ; DR B4RPZ2, ISPH_NEIG2 ; A9M1J9, ISPH_NEIM0 ; P65191, ISPH_NEIMA ; DR P65192, ISPH_NEIMB ; A1KS64, ISPH_NEIMF ; Q2GDX3, ISPH_NEOSM ; DR Q82WM1, ISPH_NITEU ; A6Q2R7, ISPH_NITSB ; Q5YQ94, ISPH_NOCFA ; DR B2IZV5, ISPH_NOSP7 ; P58674, ISPH_NOSS1 ; Q316F5, ISPH_OLEA2 ; DR B1ZXD4, ISPH_OPITP ; Q6AVG6, ISPH_ORYSJ ; A6LIB3, ISPH_PARD8 ; DR A1B842, ISPH_PARDP ; Q7U9K4, ISPH_PARMW ; Q6MC97, ISPH_PARUW ; DR P57960, ISPH_PASMU ; Q6D0C6, ISPH_PECAS ; C6DF01, ISPH_PECCP ; DR B4SCU0, ISPH_PELPB ; A1ANP9, ISPH_PELPD ; A9BGS3, ISPH_PETMO ; DR B4R8T7, ISPH_PHEZH ; Q7N8W9, ISPH_PHOLL ; Q6LUK8, ISPH_PHOPR ; DR A6L1P5, ISPH_PHOV8 ; Q8I295, ISPH_PLAF7 ; Q12EY5, ISPH_POLSJ ; DR Q7MWK6, ISPH_PORGI ; B4S4X8, ISPH_PROA2 ; A3PAY5, ISPH_PROM0 ; DR A2C096, ISPH_PROM1 ; A2CCK3, ISPH_PROM3 ; A9BDN6, ISPH_PROM4 ; DR A2BUP5, ISPH_PROM5 ; Q31CR8, ISPH_PROM9 ; Q7VDS2, ISPH_PROMA ; DR B4F2T8, ISPH_PROMH ; Q7V4T7, ISPH_PROMM ; Q7V329, ISPH_PROMP ; DR A2BP63, ISPH_PROMS ; Q46HB0, ISPH_PROMT ; Q48NK3, ISPH_PSE14 ; DR Q15R07, ISPH_PSEA6 ; B7V0A0, ISPH_PSEA8 ; Q02GC0, ISPH_PSEAB ; DR Q9HVM7, ISPH_PSEAE ; Q1I4S8, ISPH_PSEE4 ; Q4K5U7, ISPH_PSEF5 ; DR P21864, ISPH_PSEFL ; C3KDX7, ISPH_PSEFS ; A8F7S0, ISPH_PSELT ; DR A4XQV8, ISPH_PSEMY ; A5VY55, ISPH_PSEP1 ; Q3K6L8, ISPH_PSEPF ; DR B0KM87, ISPH_PSEPG ; Q88Q89, ISPH_PSEPK ; B1JF80, ISPH_PSEPW ; DR Q889E1, ISPH_PSESM ; Q3IE99, ISPH_PSET1 ; Q4ZYJ1, ISPH_PSEU2 ; DR Q4FQY8, ISPH_PSYA2 ; Q1Q974, ISPH_PSYCK ; A1SZP0, ISPH_PSYIN ; DR A5WCZ2, ISPH_PSYWF ; P58677, ISPH_RALN1 ; B3PSB9, ISPH_RHIE6 ; DR Q1MKH8, ISPH_RHIJ3 ; Q985W3, ISPH_RHILO ; B5ZSV9, ISPH_RHILW ; DR Q92RG2, ISPH_RHIME ; B9JAQ2, ISPH_RHIR8 ; Q7ULU1, ISPH_RHOBA ; DR C1A2V7, ISPH_RHOE4 ; Q0S489, ISPH_RHOJR ; C1AYI4, ISPH_RHOOB ; DR B7K4V8, ISPH_RIPO1 ; Q16AJ6, ISPH_ROSDO ; Q5LNJ7, ISPH_RUEPO ; DR Q1GDG5, ISPH_RUEST ; A1AXS1, ISPH_RUTMC ; Q21HK6, ISPH_SACD2 ; DR B5F728, ISPH_SALA4 ; A9MR43, ISPH_SALAR ; Q57TL2, ISPH_SALCH ; DR B5FHE3, ISPH_SALDC ; B5R1N9, ISPH_SALEP ; B5RG84, ISPH_SALG2 ; DR B4TIE9, ISPH_SALHS ; B4T6H5, ISPH_SALNS ; Q5PKI4, ISPH_SALPA ; DR A9MYG8, ISPH_SALPB ; C0Q4I9, ISPH_SALPC ; B5BLL3, ISPH_SALPK ; DR B4TWP0, ISPH_SALSV ; P58678, ISPH_SALTI ; P58679, ISPH_SALTY ; DR A8G9L7, ISPH_SERP5 ; B0TJB2, ISPH_SHEHH ; Q8EBI7, ISPH_SHEON ; DR A8H1H6, ISPH_SHEPA ; B2U248, ISPH_SHIB3 ; Q326J4, ISPH_SHIBS ; DR Q32K68, ISPH_SHIDS ; Q0T8G5, ISPH_SHIF8 ; Q7UDT8, ISPH_SHIFL ; DR Q3Z5Y1, ISPH_SHISS ; Q5WHC6, ISPH_SHOC1 ; Q2NVY3, ISPH_SODGM ; DR C4XUD2, ISPH_SOLM1 ; Q82IE8, ISPH_STRAW ; Q9FBM1, ISPH_STRCO ; DR B1W2D7, ISPH_STRGG ; B4SP20, ISPH_STRM5 ; B2FU83, ISPH_STRMK ; DR Q30S81, ISPH_SULDN ; A6Q7P9, ISPH_SULNB ; Q67QZ8, ISPH_SYMTH ; DR Q3A3D3, ISPH_SYNC1 ; Q31S64, ISPH_SYNE7 ; B1XPG7, ISPH_SYNP2 ; DR Q5N249, ISPH_SYNP6 ; A5GIF7, ISPH_SYNPW ; A5GWG3, ISPH_SYNR3 ; DR Q0IDE5, ISPH_SYNS3 ; Q3B080, ISPH_SYNS9 ; Q3AN10, ISPH_SYNSC ; DR Q55643, ISPH_SYNY3 ; Q9X1F7, ISPH_THEMA ; B9K8E2, ISPH_THENN ; DR A5IME1, ISPH_THEP1 ; B0K9L0, ISPH_THEP3 ; B0K197, ISPH_THEPX ; DR B1LBI2, ISPH_THESQ ; Q72G65, ISPH_THET2 ; Q5SMC8, ISPH_THET8 ; DR Q8DK29, ISPH_THEVB ; B8GQR4, ISPH_THISH ; C4LD10, ISPH_TOLAT ; DR Q73NQ6, ISPH_TREDE ; O83558, ISPH_TREPA ; B2S3D9, ISPH_TREPS ; DR Q10WA8, ISPH_TRIEI ; B3E441, ISPH_TRIL1 ; Q3M8X6, ISPH_TRIV2 ; DR Q83NB2, ISPH_TROW8 ; Q83MR9, ISPH_TROWT ; A5CVK1, ISPH_VESOH ; DR Q9KU44, ISPH_VIBCH ; Q87S87, ISPH_VIBPA ; Q8DET0, ISPH_VIBVU ; DR Q7MNM5, ISPH_VIBVY ; Q8D2R2, ISPH_WIGBR ; Q73FQ1, ISPH_WOLPM ; DR B3CM01, ISPH_WOLPP ; Q7M8Y6, ISPH_WOLSU ; Q5GTN6, ISPH_WOLTR ; DR C0R4T5, ISPH_WOLWR ; Q8PN17, ISPH_XANAC ; Q3BW40, ISPH_XANC5 ; DR Q4US42, ISPH_XANC8 ; B0RY26, ISPH_XANCB ; Q8PBG4, ISPH_XANCP ; DR Q2P5A8, ISPH_XANOM ; B2STC6, ISPH_XANOP ; Q5H2D9, ISPH_XANOR ; DR B2I6V0, ISPH_XYLF2 ; P65193, ISPH_XYLFA ; B0U3Q7, ISPH_XYLFM ; DR P65194, ISPH_XYLFT ; A1JJE4, ISPH_YERE8 ; A7FMD4, ISPH_YERP3 ; DR Q1C0J0, ISPH_YERPA ; B2K3M9, ISPH_YERPB ; P58680, ISPH_YERPE ; DR A9R005, ISPH_YERPG ; Q1CMU8, ISPH_YERPN ; A4TQF0, ISPH_YERPP ; DR Q66ES1, ISPH_YERPS ; B1JKZ5, ISPH_YERPY ; Q5NP61, ISPH_ZYMMO ; //