ID   1.17.7.4
DE   4-hydroxy-3-methylbut-2-enyl diphosphate reductase.
AN   (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase.
AN   HMBPP reductase.
CA   (1) H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] =
CA   (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-
CA   2S]-[ferredoxin].
CA   (2) dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] =
CA   (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-
CA   2S]-[ferredoxin].
CC   -!- Forms a system with a ferredoxin or a flavodoxin and an
CC       NAD(P)H-dependent reductase.
CC   -!- This is the last enzyme in the non-mevalonate pathway for isoprenoid
CC       biosynthesis.
CC   -!- This pathway, also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP)
CC       or as the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found
CC       in most bacteria and in plant chloroplasts.
CC   -!- The enzyme acts in the reverse direction, producing a 5:1 mixture of
CC       isopentenyl diphosphate and prenyl diphosphate.
CC   -!- Formerly EC 1.17.1.2.
DR   Q89UU5, ISPH1_BRADU;  Q629Z7, ISPH1_BURMA;  Q63WH0, ISPH1_BURPS;
DR   P0A5I1, ISPH1_MYCBO;  P9WKF8, ISPH1_MYCTO;  P9WKF9, ISPH1_MYCTU;
DR   Q6N3G0, ISPH1_RHOPA;  Q89QW7, ISPH2_BRADU;  Q62HM8, ISPH2_BURMA;
DR   P0DMK8, ISPH2_BURPS;  P0A5I3, ISPH2_MYCBO;  P9WKG0, ISPH2_MYCTO;
DR   P9WKG1, ISPH2_MYCTU;  Q6N1Y1, ISPH2_RHOPA;  B0C4N8, ISPH_ACAM1 ;
DR   Q9RBJ0, ISPH_ACIAD ;  B7GVR1, ISPH_ACIB3 ;  B7IAU0, ISPH_ACIB5 ;
DR   B2HZW3, ISPH_ACIBC ;  B0VQ53, ISPH_ACIBS ;  A3M9H2, ISPH_ACIBT ;
DR   B0V8K4, ISPH_ACIBY ;  A0LW20, ISPH_ACIC1 ;  B7JBD6, ISPH_ACIF2 ;
DR   B5ERJ7, ISPH_ACIF5 ;  A3N2G8, ISPH_ACTP2 ;  B3GYK1, ISPH_ACTP7 ;
DR   B0BRB3, ISPH_ACTPJ ;  A6VQH8, ISPH_ACTSZ ;  A0KG42, ISPH_AERHH ;
DR   A4SIX8, ISPH_AERS4 ;  P58673, ISPH_AGRFC ;  B9JAQ2, ISPH_AGRRK ;
DR   Q0VSD8, ISPH_ALCBS ;  Q5E7N1, ISPH_ALIF1 ;  B5FA63, ISPH_ALIFM ;
DR   B6ENC7, ISPH_ALISL ;  Q5WHC6, ISPH_ALKCK ;  A6TRF9, ISPH_ALKMQ ;
DR   A8MFE2, ISPH_ALKOO ;  A7HCQ8, ISPH_ANADF ;  B9KIX9, ISPH_ANAMF ;
DR   Q5PAE7, ISPH_ANAMM ;  B4UEK4, ISPH_ANASK ;  B7GH78, ISPH_ANOFW ;
DR   O67625, ISPH_AQUAE ;  Q94B35, ISPH_ARATH ;  Q5P224, ISPH_AROAE ;
DR   B6YQB8, ISPH_AZOPC ;  A1K4R4, ISPH_AZOSB ;  C1DPH8, ISPH_AZOVD ;
DR   C3P8J4, ISPH_BACAA ;  C3LKW7, ISPH_BACAC ;  A0RIR1, ISPH_BACAH ;
DR   Q81LU9, ISPH_BACAN ;  B7JN13, ISPH_BACC0 ;  Q730P8, ISPH_BACC1 ;
DR   B7IYD9, ISPH_BACC2 ;  C1ESI2, ISPH_BACC3 ;  B7HCR2, ISPH_BACC4 ;
DR   B7HPI8, ISPH_BACC7 ;  A7GSY4, ISPH_BACCN ;  B9IY56, ISPH_BACCQ ;
DR   Q634Q0, ISPH_BACCZ ;  Q5L9K3, ISPH_BACFN ;  Q64PU1, ISPH_BACFR ;
DR   Q6HDN0, ISPH_BACHK ;  Q65H97, ISPH_BACLD ;  A9VHR7, ISPH_BACMK ;
DR   A8FFA1, ISPH_BACP2 ;  P54473, ISPH_BACSU ;  Q8A625, ISPH_BACTN ;
DR   A7Z6T1, ISPH_BACVZ ;  A1URX2, ISPH_BARBK ;  Q6G4C5, ISPH_BARHE ;
DR   Q6G0C9, ISPH_BARQU ;  A9IQQ9, ISPH_BART1 ;  Q1LSS7, ISPH_BAUCH ;
DR   B2IED0, ISPH_BEII9 ;  Q8G4L8, ISPH_BIFLO ;  Q493S1, ISPH_BLOPB ;
DR   Q7WHF2, ISPH_BORBR ;  Q7W9B4, ISPH_BORPA ;  Q7VYS2, ISPH_BORPE ;
DR   A0A2Z5WA18, ISPH_BOTBR ;  C0ZL73, ISPH_BREBN ;  B2S9W9, ISPH_BRUA1 ;
DR   A6WWG6, ISPH_BRUA4 ;  Q57EP6, ISPH_BRUAB ;  Q8YFR1, ISPH_BRUME ;
DR   Q8G257, ISPH_BRUSU ;  B8D8U8, ISPH_BUCA5 ;  P57247, ISPH_BUCAI ;
DR   Q8K9Z4, ISPH_BUCAP ;  B8D752, ISPH_BUCAT ;  I1WW99, ISPH_BURP2 ;
DR   Q8RA76, ISPH_CALS4 ;  A7ZCD0, ISPH_CAMC1 ;  A7GXB5, ISPH_CAMC5 ;
DR   A0RQC4, ISPH_CAMFF ;  A7I0N0, ISPH_CAMHC ;  A8FLU3, ISPH_CAMJ8 ;
DR   A7H3F3, ISPH_CAMJD ;  P0C632, ISPH_CAMJE ;  A1VZM8, ISPH_CAMJJ ;
DR   Q5HUR4, ISPH_CAMJR ;  B9KD74, ISPH_CAMLR ;  Q9A345, ISPH_CAUVC ;
DR   A3PGE9, ISPH_CERS1 ;  Q3J5X0, ISPH_CERS4 ;  A4WVQ4, ISPH_CERS5 ;
DR   Q11KC7, ISPH_CHESB ;  Q5L5D3, ISPH_CHLAB ;  Q3AT23, ISPH_CHLCH ;
DR   Q822D9, ISPH_CHLCV ;  Q255J4, ISPH_CHLFF ;  B3EFF5, ISPH_CHLL2 ;
DR   Q3B241, ISPH_CHLL3 ;  Q9PL59, ISPH_CHLMU ;  B3QQE0, ISPH_CHLP8 ;
DR   B3EM42, ISPH_CHLPB ;  A1BDJ5, ISPH_CHLPD ;  A4SGC0, ISPH_CHLPM ;
DR   Q9Z6P2, ISPH_CHLPN ;  B0B991, ISPH_CHLT2 ;  B3QSU2, ISPH_CHLT3 ;
DR   Q3KKH8, ISPH_CHLTA ;  B0BAX0, ISPH_CHLTB ;  Q8KFN9, ISPH_CHLTE ;
DR   O84867, ISPH_CHLTR ;  Q1R0B2, ISPH_CHRSD ;  Q7NS59, ISPH_CHRVO ;
DR   B5E9S9, ISPH_CITBB ;  A8ALT3, ISPH_CITK8 ;  Q97I09, ISPH_CLOAB ;
DR   Q187C6, ISPH_CLOD6 ;  Q0TRF3, ISPH_CLOP1 ;  P58675, ISPH_CLOPE ;
DR   Q0STT3, ISPH_CLOPS ;  Q895G2, ISPH_CLOTE ;  Q486R1, ISPH_COLP3 ;
DR   Q6NI36, ISPH_CORDI ;  Q8FQP0, ISPH_COREF ;  A4QCY9, ISPH_CORGB ;
DR   Q8NRM2, ISPH_CORGL ;  B1WTZ2, ISPH_CROS5 ;  A7MIM0, ISPH_CROS8 ;
DR   Q6AA89, ISPH_CUTAK ;  B8HWD3, ISPH_CYAP4 ;  Q11YY5, ISPH_CYTH3 ;
DR   Q47BK8, ISPH_DECAR ;  Q3Z6U4, ISPH_DEHM1 ;  A5FPY7, ISPH_DEHMB ;
DR   Q3ZYL6, ISPH_DEHMC ;  Q9RSG0, ISPH_DEIRA ;  B8J3G9, ISPH_DESDA ;
DR   Q6AL80, ISPH_DESPS ;  Q72G08, ISPH_DESVH ;  B8DMK7, ISPH_DESVM ;
DR   A1VHK1, ISPH_DESVV ;  B5YEC2, ISPH_DICT6 ;  B8E2T7, ISPH_DICTD ;
DR   A8LLC7, ISPH_DINSH ;  A7ZHB8, ISPH_ECO24 ;  B7UI74, ISPH_ECO27 ;
DR   B7MAE9, ISPH_ECO45 ;  B7L4F1, ISPH_ECO55 ;  P62625, ISPH_ECO57 ;
DR   B5YYC1, ISPH_ECO5E ;  B7NHD3, ISPH_ECO7I ;  B7MNN4, ISPH_ECO81 ;
DR   B7M0C5, ISPH_ECO8A ;  C4ZPV5, ISPH_ECOBW ;  B1XBF4, ISPH_ECODH ;
DR   A7ZVX7, ISPH_ECOHS ;  A1A777, ISPH_ECOK1 ;  Q0TLW2, ISPH_ECOL5 ;
DR   P62624, ISPH_ECOL6 ;  B1IRE6, ISPH_ECOLC ;  P62623, ISPH_ECOLI ;
DR   B7N7Q3, ISPH_ECOLU ;  B6HYX7, ISPH_ECOSE ;  B1LFV9, ISPH_ECOSM ;
DR   Q1RGH3, ISPH_ECOUT ;  C5B7M7, ISPH_EDWI9 ;  Q5FFL5, ISPH_EHRRG ;
DR   Q5HB13, ISPH_EHRRW ;  A4W6E4, ISPH_ENT38 ;  B2VH04, ISPH_ERWT9 ;
DR   B7LVN5, ISPH_ESCF3 ;  B1YL84, ISPH_EXIS2 ;  C4L3Z5, ISPH_EXISA ;
DR   B0U064, ISPH_FRAP2 ;  Q14I06, ISPH_FRAT1 ;  A7NA22, ISPH_FRATF ;
DR   Q2A587, ISPH_FRATH ;  B2SES8, ISPH_FRATM ;  A0Q4T9, ISPH_FRATN ;
DR   Q0BNK1, ISPH_FRATO ;  Q5NGK4, ISPH_FRATT ;  A4IYW2, ISPH_FRATW ;
DR   Q8RI52, ISPH_FUSNN ;  B9LZG4, ISPH_GEODF ;  Q5KX24, ISPH_GEOKA ;
DR   Q39XB6, ISPH_GEOMG ;  Q749Y8, ISPH_GEOSL ;  C6E2B3, ISPH_GEOSM ;
DR   C5D4R3, ISPH_GEOSW ;  A4IR05, ISPH_GEOTN ;  A5GE10, ISPH_GEOUR ;
DR   B8F6E6, ISPH_GLAP5 ;  B7KEG3, ISPH_GLOC7 ;  Q7NG74, ISPH_GLOVI ;
DR   Q5FUH7, ISPH_GLUOX ;  Q7VPK4, ISPH_HAEDU ;  Q4QLQ5, ISPH_HAEI8 ;
DR   A5UD69, ISPH_HAEIE ;  A5UID9, ISPH_HAEIG ;  P44976, ISPH_HAEIN ;
DR   Q2S9U2, ISPH_HAHCH ;  Q9KD37, ISPH_HALH5 ;  C4K4R2, ISPH_HAMD5 ;
DR   Q7VJV5, ISPH_HELHP ;  B6JMP4, ISPH_HELP2 ;  Q1CSL3, ISPH_HELPH ;
DR   P65186, ISPH_HELPJ ;  B2UUG0, ISPH_HELPS ;  P65185, ISPH_HELPY ;
DR   B0UV08, ISPH_HISS2 ;  Q0BYQ0, ISPH_HYPNA ;  Q5QZR7, ISPH_IDILO ;
DR   B5Y232, ISPH_KLEP3 ;  A6T4G3, ISPH_KLEP7 ;  C5CIU9, ISPH_KOSOT ;
DR   Q6ADV0, ISPH_LEIXX ;  Q72S57, ISPH_LEPIC ;  Q8F3I3, ISPH_LEPIN ;
DR   C1KV98, ISPH_LISMC ;  Q71ZL9, ISPH_LISMF ;  P58676, ISPH_LISMO ;
DR   B1HTG5, ISPH_LYSSC ;  B9E6U8, ISPH_MACCJ ;  A0LD71, ISPH_MAGMM ;
DR   Q8EWR9, ISPH_MALP2 ;  Q65RQ4, ISPH_MANSM ;  A1TYZ2, ISPH_MARN8 ;
DR   Q607E5, ISPH_METCA ;  A2SJA8, ISPH_METPP ;  B8EQB9, ISPH_METSB ;
DR   B0JVA7, ISPH_MICAN ;  A4T986, ISPH_MYCGI ;  Q9X781, ISPH_MYCLE ;
DR   Q73WH6, ISPH_MYCPA ;  A3Q4N0, ISPH_MYCSJ ;  A1UKL5, ISPH_MYCSK ;
DR   Q1B4H4, ISPH_MYCSS ;  A0PKQ3, ISPH_MYCUA ;  A1TE06, ISPH_MYCVP ;
DR   B9L9K5, ISPH_NAUPA ;  Q5FAF2, ISPH_NEIG1 ;  B4RPZ2, ISPH_NEIG2 ;
DR   A9M1J9, ISPH_NEIM0 ;  P65191, ISPH_NEIMA ;  P65192, ISPH_NEIMB ;
DR   A1KS64, ISPH_NEIMF ;  Q2GDX3, ISPH_NEOSM ;  Q82WM1, ISPH_NITEU ;
DR   A6Q2R7, ISPH_NITSB ;  Q5YQ94, ISPH_NOCFA ;  B2IZV5, ISPH_NOSP7 ;
DR   P58674, ISPH_NOSS1 ;  Q316F5, ISPH_OLEA2 ;  B1ZXD4, ISPH_OPITP ;
DR   Q6AVG6, ISPH_ORYSJ ;  A6LIB3, ISPH_PARD8 ;  A1B842, ISPH_PARDP ;
DR   Q7U9K4, ISPH_PARMW ;  Q6MC97, ISPH_PARUW ;  P57960, ISPH_PASMU ;
DR   Q6D0C6, ISPH_PECAS ;  C6DF01, ISPH_PECCP ;  B4SCU0, ISPH_PELPB ;
DR   A1ANP9, ISPH_PELPD ;  A9BGS3, ISPH_PETMO ;  B4R8T7, ISPH_PHEZH ;
DR   Q7N8W9, ISPH_PHOLL ;  Q6LUK8, ISPH_PHOPR ;  A6L1P5, ISPH_PHOV8 ;
DR   Q8I295, ISPH_PLAF7 ;  Q12EY5, ISPH_POLSJ ;  Q7MWK6, ISPH_PORGI ;
DR   B4S4X8, ISPH_PROA2 ;  A3PAY5, ISPH_PROM0 ;  A2C096, ISPH_PROM1 ;
DR   A2CCK3, ISPH_PROM3 ;  A9BDN6, ISPH_PROM4 ;  A2BUP5, ISPH_PROM5 ;
DR   Q31CR8, ISPH_PROM9 ;  Q7VDS2, ISPH_PROMA ;  B4F2T8, ISPH_PROMH ;
DR   Q7V4T7, ISPH_PROMM ;  Q7V329, ISPH_PROMP ;  A2BP63, ISPH_PROMS ;
DR   Q46HB0, ISPH_PROMT ;  Q48NK3, ISPH_PSE14 ;  Q15R07, ISPH_PSEA6 ;
DR   B7V0A0, ISPH_PSEA8 ;  Q02GC0, ISPH_PSEAB ;  Q9HVM7, ISPH_PSEAE ;
DR   Q1I4S8, ISPH_PSEE4 ;  Q4K5U7, ISPH_PSEF5 ;  P21864, ISPH_PSEFL ;
DR   C3KDX7, ISPH_PSEFS ;  A8F7S0, ISPH_PSELT ;  A4XQV8, ISPH_PSEMY ;
DR   A5VY55, ISPH_PSEP1 ;  Q3K6L8, ISPH_PSEPF ;  B0KM87, ISPH_PSEPG ;
DR   Q88Q89, ISPH_PSEPK ;  B1JF80, ISPH_PSEPW ;  Q889E1, ISPH_PSESM ;
DR   Q3IE99, ISPH_PSET1 ;  Q4ZYJ1, ISPH_PSEU2 ;  Q4FQY8, ISPH_PSYA2 ;
DR   Q1Q974, ISPH_PSYCK ;  A1SZP0, ISPH_PSYIN ;  A5WCZ2, ISPH_PSYWF ;
DR   P58677, ISPH_RALN1 ;  B3PSB9, ISPH_RHIE6 ;  Q1MKH8, ISPH_RHIL3 ;
DR   Q985W3, ISPH_RHILO ;  B5ZSV9, ISPH_RHILW ;  Q92RG2, ISPH_RHIME ;
DR   Q7ULU1, ISPH_RHOBA ;  C1A2V7, ISPH_RHOE4 ;  Q0S489, ISPH_RHOJR ;
DR   C1AYI4, ISPH_RHOOB ;  B7K4V8, ISPH_RIPO1 ;  Q16AJ6, ISPH_ROSDO ;
DR   Q5LNJ7, ISPH_RUEPO ;  Q1GDG5, ISPH_RUEST ;  A1AXS1, ISPH_RUTMC ;
DR   Q21HK6, ISPH_SACD2 ;  B5F728, ISPH_SALA4 ;  A9MR43, ISPH_SALAR ;
DR   Q57TL2, ISPH_SALCH ;  B5FHE3, ISPH_SALDC ;  B5R1N9, ISPH_SALEP ;
DR   B5RG84, ISPH_SALG2 ;  B4TIE9, ISPH_SALHS ;  B4T6H5, ISPH_SALNS ;
DR   Q5PKI4, ISPH_SALPA ;  A9MYG8, ISPH_SALPB ;  C0Q4I9, ISPH_SALPC ;
DR   B5BLL3, ISPH_SALPK ;  B4TWP0, ISPH_SALSV ;  P58678, ISPH_SALTI ;
DR   P58679, ISPH_SALTY ;  A8G9L7, ISPH_SERP5 ;  B0TJB2, ISPH_SHEHH ;
DR   Q8EBI7, ISPH_SHEON ;  A8H1H6, ISPH_SHEPA ;  B2U248, ISPH_SHIB3 ;
DR   Q326J4, ISPH_SHIBS ;  Q32K68, ISPH_SHIDS ;  Q0T8G5, ISPH_SHIF8 ;
DR   Q7UDT8, ISPH_SHIFL ;  Q3Z5Y1, ISPH_SHISS ;  Q2NVY3, ISPH_SODGM ;
DR   C4XUD2, ISPH_SOLM1 ;  Q82IE8, ISPH_STRAW ;  Q9FBM1, ISPH_STRCO ;
DR   B1W2D7, ISPH_STRGG ;  B4SP20, ISPH_STRM5 ;  B2FU83, ISPH_STRMK ;
DR   Q30S81, ISPH_SULDN ;  A6Q7P9, ISPH_SULNB ;  Q67QZ8, ISPH_SYMTH ;
DR   Q3A3D3, ISPH_SYNC1 ;  Q31S64, ISPH_SYNE7 ;  B1XPG7, ISPH_SYNP2 ;
DR   Q5N249, ISPH_SYNP6 ;  A5GIF7, ISPH_SYNPW ;  A5GWG3, ISPH_SYNR3 ;
DR   Q0IDE5, ISPH_SYNS3 ;  Q3B080, ISPH_SYNS9 ;  Q3AN10, ISPH_SYNSC ;
DR   Q55643, ISPH_SYNY3 ;  Q9X1F7, ISPH_THEMA ;  B9K8E2, ISPH_THENN ;
DR   A5IME1, ISPH_THEP1 ;  B0K9L0, ISPH_THEP3 ;  B0K197, ISPH_THEPX ;
DR   B1LBI2, ISPH_THESQ ;  Q72G65, ISPH_THET2 ;  Q5SMC8, ISPH_THET8 ;
DR   Q8DK29, ISPH_THEVB ;  B8GQR4, ISPH_THISH ;  C4LD10, ISPH_TOLAT ;
DR   Q73NQ6, ISPH_TREDE ;  O83558, ISPH_TREPA ;  B2S3D9, ISPH_TREPS ;
DR   Q10WA8, ISPH_TRIEI ;  B3E441, ISPH_TRIL1 ;  Q3M8X6, ISPH_TRIV2 ;
DR   Q83NB2, ISPH_TROW8 ;  Q83MR9, ISPH_TROWT ;  A5CVK1, ISPH_VESOH ;
DR   Q9KU44, ISPH_VIBCH ;  Q87S87, ISPH_VIBPA ;  Q8DET0, ISPH_VIBVU ;
DR   Q7MNM5, ISPH_VIBVY ;  Q8D2R2, ISPH_WIGBR ;  Q73FQ1, ISPH_WOLPM ;
DR   B3CM01, ISPH_WOLPP ;  Q7M8Y6, ISPH_WOLSU ;  Q5GTN6, ISPH_WOLTR ;
DR   C0R4T5, ISPH_WOLWR ;  Q8PN17, ISPH_XANAC ;  Q3BW40, ISPH_XANC5 ;
DR   Q4US42, ISPH_XANC8 ;  B0RY26, ISPH_XANCB ;  Q8PBG4, ISPH_XANCP ;
DR   Q2P5A8, ISPH_XANOM ;  B2STC6, ISPH_XANOP ;  Q5H2D9, ISPH_XANOR ;
DR   B2I6V0, ISPH_XYLF2 ;  P65193, ISPH_XYLFA ;  B0U3Q7, ISPH_XYLFM ;
DR   P65194, ISPH_XYLFT ;  A1JJE4, ISPH_YERE8 ;  A7FMD4, ISPH_YERP3 ;
DR   Q1C0J0, ISPH_YERPA ;  B2K3M9, ISPH_YERPB ;  P58680, ISPH_YERPE ;
DR   A9R005, ISPH_YERPG ;  Q1CMU8, ISPH_YERPN ;  A4TQF0, ISPH_YERPP ;
DR   Q66ES1, ISPH_YERPS ;  B1JKZ5, ISPH_YERPY ;  Q5NP61, ISPH_ZYMMO ;
//