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ENZYME

ENZYME entry: EC 1.17.99.10

PURL: https://purl.expasy.org/enzyme/EC/1.17.99.10
Accepted Name
steroid C-25 hydroxylase
Alternative Name(s)
cholesterol C-25 dehydrogenase
steroid C-25 dehydrogenase
Reaction catalysed
cholest-4-en-3-one + A + H2O = 25-hydroxycholest-4-en-3-one + AH2
Comment(s)
  • The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol.
  • The enzyme can accept several substrates including vitamin D3.
  • The enzyme contains a bis(guanylyl molybdopterin) cofactor, five [Fe-S] clusters, and one heme b. cf. EC 1.14.99.38.
Cross-references
BRENDA1.17.99.10
EC2PDB1.17.99.10
ExplorEnz1.17.99.10
KEGG Ligand Database for Enzyme Nomenclature1.17.99.10
IUBMB Enzyme Nomenclature1.17.99.10
MEDLINEFind literature relating to 1.17.99.10
MetaCyc1.17.99.10
Rhea expert-curated reactions1.17.99.10

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-