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ENZYME entry: EC 1.17.99.10

Accepted Name
Steroid C-25 hydroxylase.
Alternative Name(s)
Cholesterol C-25 dehydrogenase.
Steroid C-25 dehydrogenase.
Reaction catalysed
Cholest-4-en-3-one + acceptor + H(2)O <=> 25-hydroxycholest-4-en-3-one + reduced acceptor
Comment(s)
  • The enzyme, characterized from the bacterium Sterolibacterium denitrificans, participates in the anaerobic degradation of cholesterol.
  • The enzyme can accept several substrates including vitamin D(3).
  • The enzyme contains a bis(guanylyl molybdopterin) cofactor, five (Fe-S) clusters, and one heme b.
  • Cf. EC 1.14.99.38.
Cross-references
BRENDA1.17.99.10
EC2PDB1.17.99.10
ExplorEnz1.17.99.10
PRIAM enzyme-specific profiles1.17.99.10
KEGG Ligand Database for Enzyme Nomenclature1.17.99.10
IUBMB Enzyme Nomenclature1.17.99.10
IntEnz1.17.99.10
MEDLINEFind literature relating to 1.17.99.10
MetaCyc1.17.99.10
Rhea expert-curated reactions1.17.99.10

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