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ENZYME entry: EC 1.17.99.6

Accepted Name
epoxyqueuosine reductase
Alternative Name(s)
oQ reductase
Reaction catalysed
AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA
Comment(s)
  • This enzyme catalyzes the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn.
  • Two types of enzymes are known to catalyze this activity.
  • QueG enzymes are cobalamin-dependent, while QueH enzymes contain a [4Fe-4S] metallocluster along with an adjacent coordinated iron metal.
Cross-references
BRENDA1.17.99.6
EC2PDB1.17.99.6
ExplorEnz1.17.99.6
PRIAM enzyme-specific profiles1.17.99.6
KEGG Ligand Database for Enzyme Nomenclature1.17.99.6
IUBMB Enzyme Nomenclature1.17.99.6
IntEnz1.17.99.6
MEDLINEFind literature relating to 1.17.99.6
MetaCyc1.17.99.6
Rhea expert-curated reactions1.17.99.6
UniProtKB/Swiss-Prot
F4G4E2, QUEG_ALIDKQ5E2C3, QUEG_ALIF1D3ENT3, QUEG_ATETH
Q81YT7, QUEG_BACANQ81I72, QUEG_BACCRP97030, QUEG_BACSU
Q63WN0, QUEG_BURPSE6X4P3, QUEG_CELADG0J2F8, QUEG_CYCMS
P39288, QUEG_ECOLIQ834R1, QUEG_ENTFAA6H1G2, QUEG_FLAPJ
F4BEN2, QUEG_FRACFQ7NKL3, QUEG_GLOVIF9VEN7, QUEG_LACGL
E4RUV9, QUEG_LEAB4Q8Y8H0, QUEG_LISMOQ46I55, QUEG_PROMT
Q9HUL4, QUEG_PSEAEF7ZDR3, QUEG_ROSLOQ8ZKA8, QUEG_SALTY
Q8EAN7, QUEG_SHEONQ328E3, QUEG_SHIDSQ2FX88, QUEG_STAA8
A5GPV1, QUEG_SYNR3Q3ANP3, QUEG_SYNSCP73526, QUEG_SYNY3
Q8DLA9, QUEG_THEVBQ9KV16, QUEG_VIBCHQ8P8E0, QUEG_XANCP
Q7CKM4, QUEG_YERPEQ6FAK7, QUEH_ACIADQ7VYQ1, QUEH_BORPE
Q3Z8V0, QUEH_DEHM1P44068, QUEH_HAEINO24926, QUEH_HELPY
Q0I1Q0, QUEH_HISS1A0A0H3JUG6, QUEH_STAAMA0A0H2VKG8, QUEH_STAES
Q9A1K3, QUEH_STRP1Q9WZJ0, QUEH_THEMA

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