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ENZYME entry: EC 1.17.99.6

Accepted Name
epoxyqueuosine reductase.
Alternative Name(s)
oQ reductase.
Reaction catalysed
AH2 + epoxyqueuosine(34) in tRNA <=> A + H2O + queuosine(34) in tRNA
Comment(s)
  • This enzyme catalyzes the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn.
  • Two types of enzymes are known to catalyze this activity.
  • QueG enzymes are cobalamin-dependent, while QueH enzymes contain a [4Fe-4S] metallocluster along with an adjacent coordinated iron metal.
Cross-references
BRENDA1.17.99.6
EC2PDB1.17.99.6
ExplorEnz1.17.99.6
PRIAM enzyme-specific profiles1.17.99.6
KEGG Ligand Database for Enzyme Nomenclature1.17.99.6
IUBMB Enzyme Nomenclature1.17.99.6
IntEnz1.17.99.6
MEDLINEFind literature relating to 1.17.99.6
MetaCyc1.17.99.6
Rhea expert-curated reactions1.17.99.6
UniProtKB/Swiss-Prot
F4G4E2, QUEG_ALIDK;  Q5E2C3, QUEG_ALIF1;  D3ENT3, QUEG_ATETH;  
Q81YT7, QUEG_BACAN;  Q81I72, QUEG_BACCR;  P97030, QUEG_BACSU;  
Q63WN0, QUEG_BURPS;  E6X4P3, QUEG_CELAD;  G0J2F8, QUEG_CYCMS;  
P39288, QUEG_ECOLI;  Q834R1, QUEG_ENTFA;  A6H1G2, QUEG_FLAPJ;  
F4BEN2, QUEG_FRACF;  Q7NKL3, QUEG_GLOVI;  F9VEN7, QUEG_LACGL;  
E4RUV9, QUEG_LEAB4;  Q8Y8H0, QUEG_LISMO;  Q46I55, QUEG_PROMT;  
Q9HUL4, QUEG_PSEAE;  F7ZDR3, QUEG_ROSLO;  Q8ZKA8, QUEG_SALTY;  
Q8EAN7, QUEG_SHEON;  Q328E3, QUEG_SHIDS;  Q2FX88, QUEG_STAA8;  
A5GPV1, QUEG_SYNR3;  Q3ANP3, QUEG_SYNSC;  P73526, QUEG_SYNY3;  
Q8DLA9, QUEG_THEVB;  Q9KV16, QUEG_VIBCH;  Q8P8E0, QUEG_XANCP;  
Q7CKM4, QUEG_YERPE;  Q6FAK7, QUEH_ACIAD;  Q7VYQ1, QUEH_BORPE;  
Q3Z8V0, QUEH_DEHM1;  P44068, QUEH_HAEIN;  Q0I1Q0, QUEH_HAES1;  
O24926, QUEH_HELPY;  A0A0H3JUG6, QUEH_STAAM;  A0A0H2VKG8, QUEH_STAES;  
Q9A1K3, QUEH_STRP1;  Q9WZJ0, QUEH_THEMA;  

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