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ENZYME

ENZYME entry: EC 1.2.1.10

Accepted Name
acetaldehyde dehydrogenase (acetylating)
Alternative Name(s)
acylating acetaldehyde dehydrogenase
aldehyde dehydrogenase (acylating)
Reaction catalysed
acetaldehyde + NAD(+) + CoA = acetyl-CoA + NADH + H(+)
Comment(s)
  • Also acts, more slowly, on glycolaldehyde, propanal and butanal.
  • In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87.
  • Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols.
  • NADP(+) can replace NAD(+) but the rate of reaction is much slower.
Cross-references
BRENDA1.2.1.10
EC2PDB1.2.1.10
ExplorEnz1.2.1.10
KEGG Ligand Database for Enzyme Nomenclature1.2.1.10
IUBMB Enzyme Nomenclature1.2.1.10
MEDLINEFind literature relating to 1.2.1.10
MetaCyc1.2.1.10
Rhea expert-curated reactions1.2.1.10
UniProtKB/Swiss-Prot
A1K6L8, ACDH1_AZOSBC1DMT1, ACDH1_AZOVDB4EK77, ACDH1_BURCJ
Q397R0, ACDH1_BURL3A4JPX8, ACDH1_BURVGQ83VZ4, ACDH1_COMTE
Q1LNS3, ACDH1_CUPMCQ0K3S6, ACDH1_CUPNHQ47HL9, ACDH1_DECAR
Q4F8I0, ACDH1_METFUA2SI34, ACDH1_METPPB1MH39, ACDH1_MYCA9
B2HGH0, ACDH1_MYCMMA0QZU1, ACDH1_MYCS2A3Q4B8, ACDH1_MYCSJ
A1UM81, ACDH1_MYCSKQ1B2X0, ACDH1_MYCSSA0PR19, ACDH1_MYCUA
Q5Z2N3, ACDH1_NOCFAA1SH78, ACDH1_NOCSJA4XF36, ACDH1_NOVAD
B2JLM7, ACDH1_PARP8A8LAA2, ACDH1_PARS2Q143P8, ACDH1_PARXL
A5W4E5, ACDH1_PSEP1B1J6Y6, ACDH1_PSEPWA5V6T7, ACDH1_RHIWR
C0ZPX0, ACDH1_RHOE4Q0SJD4, ACDH1_RHOJRC1B7L1, ACDH1_RHOOB
A8M1N1, ACDH1_SALAIA1K6Y5, ACDH2_AZOSBC1DRI9, ACDH2_AZOVD
B4EFI8, ACDH2_BURCJQ396N9, ACDH2_BURL3A4JW24, ACDH2_BURVG
Q9RHN2, ACDH2_COMTEQ1LCQ9, ACDH2_CUPMCQ0K3N1, ACDH2_CUPNH
Q47GC7, ACDH2_DECARQ52039, ACDH2_METFUA2SL36, ACDH2_METPP
B1MJT8, ACDH2_MYCA9B2HI26, ACDH2_MYCMMA0R4S7, ACDH2_MYCS2
A3Q6N0, ACDH2_MYCSJA1UQA0, ACDH2_MYCSKQ1B0P7, ACDH2_MYCSS
A0PUX3, ACDH2_MYCUAA1TDB8, ACDH2_MYCVPQ5YV94, ACDH2_NOCFA
A1SIM4, ACDH2_NOCSJA4XDT7, ACDH2_NOVADB2JQV9, ACDH2_PARP8
A8LEP9, ACDH2_PARS2Q13VU2, ACDH2_PARXLA5W4F9, ACDH2_PSEP1
B1J6Y2, ACDH2_PSEPWC0ZU49, ACDH2_RHOE4Q0S9X0, ACDH2_RHOJR
C1B8H9, ACDH2_RHOOBA8M6W7, ACDH2_SALAIC1DN56, ACDH3_AZOVD
Q390P5, ACDH3_BURL3Q9S153, ACDH3_COMTEQ47B12, ACDH3_DECAR
A1TFQ6, ACDH3_MYCVPQ5YUH5, ACDH3_NOCFAQ13QH7, ACDH3_PARXL
A5VGU5, ACDH3_RHIWRQ0S816, ACDH3_RHOJRC1BAJ3, ACDH3_RHOOB
C1DF11, ACDH4_AZOVDQ39LH7, ACDH4_BURL3Q479G9, ACDH4_DECAR
Q79AF6, ACDH4_PARXLQ0S4F9, ACDH4_RHOJRC1AVG3, ACDH4_RHOOB
Q479E6, ACDH5_DECARQ0S005, ACDH5_RHOJRC1AYB3, ACDH5_RHOOB
Q0RXC4, ACDH6_RHOJRC1BE29, ACDH6_RHOOBQ0RWM7, ACDH7_RHOJR
A1W2K2, ACDH_ACISJQ221U6, ACDH_ALBFTQ0A5T6, ACDH_ALKEH
A0RD69, ACDH_BACAHQ739I5, ACDH_BACC1C1ERL6, ACDH_BACC3
Q2KXU8, ACDH_BORA1C0ZDU5, ACDH_BREBNQ2VLC6, ACDH_BURCE
A3P826, ACDH_BURP0Q3JK54, ACDH_BURP1A3NML3, ACDH_BURP6
Q63JB0, ACDH_BURPSQ2T7T0, ACDH_BURTAQ3ACM1, ACDH_CARHZ
A9W9U2, ACDH_CHLAAB8GBV4, ACDH_CHLADB9LCM0, ACDH_CHLSY
Q46NW7, ACDH_CUPPJB2AIJ6, ACDH_CUPTRB8G186, ACDH_DESHD
A7ZI98, ACDH_ECO24B7L507, ACDH_ECO55Q8X5J9, ACDH_ECO57
B5Z2Q6, ACDH_ECO5EB7NK04, ACDH_ECO7IB7MPB8, ACDH_ECO81
B7M2Z9, ACDH_ECO8AC4ZTB5, ACDH_ECOBWA7ZWZ8, ACDH_ECOHS
B1J0S8, ACDH_ECOLCP77580, ACDH_ECOLIB7N8Q8, ACDH_ECOLU
B6HZX7, ACDH_ECOSEB1LIN6, ACDH_ECOSMQ764S1, ACDH_GEOG3
B0VXM6, ACDH_GEOSEA4IT43, ACDH_GEOTNB5XQJ3, ACDH_KLEP3
A6TAC5, ACDH_KLEP7B1Y2E6, ACDH_LEPCPA6W1X2, ACDH_MARMS
B8ESV1, ACDH_METSBQ2RHL2, ACDH_MOOTAA0QAG8, ACDH_MYCA1
Q7TTR4, ACDH_MYCBOA1KPM0, ACDH_MYCBPC1AHZ3, ACDH_MYCBT
A4T7U3, ACDH_MYCGIQ743Q9, ACDH_MYCPAA5U8K9, ACDH_MYCTA
P9WQH2, ACDH_MYCTOP9WQH3, ACDH_MYCTUO85978, ACDH_NOVAR
B2T2S1, ACDH_PARPJQ6D797, ACDH_PECASA5D522, ACDH_PELTS
A1VUV2, ACDH_POLNAQ120P0, ACDH_POLSJQ49KG0, ACDH_PSEPU
Q9KWS1, ACDH_PSESPQ3IEN6, ACDH_PSET1Q52060, ACDH_PSEUF
Q8XRG0, ACDH_RALN1B2UJF2, ACDH_RALPJB9JML7, ACDH_RHIR8
A7NLU3, ACDH_ROSCSA5UWE5, ACDH_ROSS1A4XAK8, ACDH_SALTO
B0TTT0, ACDH_SHEHHA8H4F0, ACDH_SHEPAB1KJL0, ACDH_SHEWM
Q3Z555, ACDH_SHISSA2TC44, ACDH_SPHYAQ0PHY0, ACDH_SPIAU
B1VRH6, ACDH_STRGGQ9ZI57, ACDH_STUSTB9L2J1, ACDH_THERP
Q53WH9, ACDH_THET8A1WLL3, ACDH_VEREIA7IDU5, ACDH_XANP2
Q24803, ADH2_ENTH1E5Y379, ADHE_BILW3P0A9Q8, ADHE_ECO57
P0A9Q7, ADHE_ECOLIP77445, EUTE_ECOLIP41793, EUTE_SALTY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-