Expasy logo


ENZYME entry: EC

Accepted Name
pyruvate dehydrogenase system
Alternative Name(s)
pyruvate dehydrogenase complex
Reaction catalysed
CoA + NAD(+) + pyruvate <=> acetyl-CoA + CO2 + NADH
  • The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC, EC, EC and EC
  • With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3).
  • The reaction catalyzed by this system is the sum of three activities: EC, EC, and EC
  • The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits.
PRIAM enzyme-specific profiles1.2.1.104
KEGG Ligand Database for Enzyme Nomenclature1.2.1.104
IUBMB Enzyme Nomenclature1.2.1.104
MEDLINEFind literature relating to
Rhea expert-curated reactions1.2.1.104

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-