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ENZYME

ENZYME entry: EC 1.2.1.104

Accepted Name
pyruvate dehydrogenase system
Alternative Name(s)
PDH
pyruvate dehydrogenase complex
Reaction catalysed
CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH
Comment(s)
  • The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, EC 1.2.1.105, EC 1.4.1.27 and EC 2.3.1.190.
  • With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3).
  • The reaction catalyzed by this system is the sum of three activities: EC 1.2.4.1, EC 2.3.1.12, and EC 1.8.1.4.
  • The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits.
Cross-references
BRENDA1.2.1.104
EC2PDB1.2.1.104
ExplorEnz1.2.1.104
PRIAM enzyme-specific profiles1.2.1.104
KEGG Ligand Database for Enzyme Nomenclature1.2.1.104
IUBMB Enzyme Nomenclature1.2.1.104
IntEnz1.2.1.104
MEDLINEFind literature relating to 1.2.1.104
MetaCyc1.2.1.104
Rhea expert-curated reactions1.2.1.104

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