ENZYME entry: EC 220.127.116.11
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|Pyruvate dehydrogenase system.
|Pyruvate dehydrogenase complex.|
|Pyruvate + CoA + NAD(+) <=> acetyl-CoA + CO(2) + NADH|
- The pyruvate dehydrogenase system (PDH) is a large enzyme complex
that belongs to the 2-oxoacid dehydrogenase system family, which also
includes EC 18.104.22.168, EC 22.214.171.124, EC 126.96.36.199 and EC 188.8.131.52.
- With the exception of the glycine cleavage system, which contains 4
components, the 2-oxoacid dehydrogenase systems share a common
structure, consisting of three main components, namely a 2-oxoacid
dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a
dihydrolipoamide dehydrogenase (E3).
- The reaction catalyzed by this system is the sum of three activities:
EC 184.108.40.206, EC 220.127.116.11, and EC 18.104.22.168.
- The mammalian system also includes E3 binding protein, which is
involved in the interaction between the E2 and E3 subunits.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
|Rhea expert-curated reactions||220.127.116.11|
entries corresponding to 1.2.1.-
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