ID 1.2.1.104 DE pyruvate dehydrogenase system. AN PDH. AN pyruvate dehydrogenase complex. CA CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH. CC -!- The pyruvate dehydrogenase system (PDH) is a large enzyme complex CC that belongs to the 2-oxoacid dehydrogenase system family, which also CC includes EC 1.2.1.25, EC 1.2.1.105, EC 1.4.1.27 and EC 2.3.1.190. CC -!- With the exception of the glycine cleavage system, which contains 4 CC components, the 2-oxoacid dehydrogenase systems share a common CC structure, consisting of three main components, namely a 2-oxoacid CC dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a CC dihydrolipoamide dehydrogenase (E3). CC -!- The reaction catalyzed by this system is the sum of three activities: CC EC 1.2.4.1, EC 2.3.1.12, and EC 1.8.1.4. CC -!- The mammalian system also includes E3 binding protein, which is CC involved in the interaction between the E2 and E3 subunits. //