ID   1.2.1.104
DE   pyruvate dehydrogenase system.
AN   PDH.
AN   pyruvate dehydrogenase complex.
CA   CoA + NAD(+) + pyruvate = acetyl-CoA + CO2 + NADH.
CC   -!- The pyruvate dehydrogenase system (PDH) is a large enzyme complex
CC       that belongs to the 2-oxoacid dehydrogenase system family, which also
CC       includes EC 1.2.1.25, EC 1.2.1.105, EC 1.4.1.27 and EC 2.3.1.190.
CC   -!- With the exception of the glycine cleavage system, which contains 4
CC       components, the 2-oxoacid dehydrogenase systems share a common
CC       structure, consisting of three main components, namely a 2-oxoacid
CC       dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a
CC       dihydrolipoamide dehydrogenase (E3).
CC   -!- The reaction catalyzed by this system is the sum of three activities:
CC       EC 1.2.4.1, EC 2.3.1.12, and EC 1.8.1.4.
CC   -!- The mammalian system also includes E3 binding protein, which is
CC       involved in the interaction between the E2 and E3 subunits.
//