ID   1.2.1.105
DE   2-oxoglutarate dehydrogenase system.
AN   2-oxoglutarate dehydrogenase complex.
CA   2-oxoglutarate + CoA + NAD(+) = CO2 + NADH + succinyl-CoA.
CC   -!- The 2-oxoglutarate dehydrogenase system is a large enzyme complex
CC       that belongs to the 2-oxoacid dehydrogenase system family, which also
CC       includes EC 1.2.1.25, EC 1.2.1.104, EC 1.4.1.27 and EC 2.3.1.190.
CC   -!- With the exception of the glycine cleavage system, which contains 4
CC       components, the 2-oxoacid dehydrogenase systems share a common
CC       structure, consisting of three main components, namely a 2-oxoacid
CC       dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a
CC       dihydrolipoamide dehydrogenase (E3).
CC   -!- This enzyme system converts 2-oxoglutarate to succinyl-CoA and
CC       produces NADH and CO2 in a complicated series of irreversible
CC       reactions.
CC   -!- The reaction catalyzed by this system is the sum of three activities:
CC       EC 1.2.4.2, EC 2.3.1.61 and EC 1.8.1.4.
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