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ENZYME

ENZYME entry: EC 1.2.1.19

PURL: https://purl.expasy.org/enzyme/EC/1.2.1.19
Accepted Name
aminobutyraldehyde dehydrogenase
Alternative Name(s)
1-pyrroline dehydrogenase
4-aminobutanal dehydrogenase
ABALDH
gamma-guanidinobutyraldehyde dehydrogenase
Reaction catalysed
4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)
Comment(s)
  • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
  • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
  • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
  • Formerly EC 1.5.1.35.
Cross-references
BRENDA1.2.1.19
EC2PDB1.2.1.19
ExplorEnz1.2.1.19
KEGG Ligand Database for Enzyme Nomenclature1.2.1.19
IUBMB Enzyme Nomenclature1.2.1.19
MEDLINEFind literature relating to 1.2.1.19
MetaCyc1.2.1.19
Rhea expert-curated reactions1.2.1.19
UniProtKB/Swiss-Prot
A0A0E3T552, AADH1_MALDOQ8VWZ1, AADH1_PEAQ56R04, AADH1_SOLLC
C6KEM4, AADH2_MAIZEA0A0E3T3B5, AADH2_MALDOQ93YB2, AADH2_PEA
B6ECN9, AADH2_SOLLCA8AGJ9, ABDH_CITK8A7ZLN7, ABDH_ECO24
B7URJ0, ABDH_ECO27B7MMS8, ABDH_ECO45B7L6F9, ABDH_ECO55
Q8X9W5, ABDH_ECO57B5Z0W0, ABDH_ECO5EB7MUN0, ABDH_ECO81
B7LZ33, ABDH_ECO8AC4ZVI3, ABDH_ECOBWB1XDF5, ABDH_ECODH
A8A002, ABDH_ECOHSA1AB46, ABDH_ECOK1Q0THX6, ABDH_ECOL5
Q8FHK7, ABDH_ECOL6B1IS15, ABDH_ECOLCP77674, ABDH_ECOLI
B7N4K1, ABDH_ECOLUB6IAI9, ABDH_ECOSEB1LFH3, ABDH_ECOSM
Q1RBX3, ABDH_ECOUTA4WAR9, ABDH_ENT38B7LR95, ABDH_ESCF3
Q6D6Y7, ABDH_PECASC6DD82, ABDH_PECCPA9MQY3, ABDH_SALAR
Q57P61, ABDH_SALCHQ5PHV8, ABDH_SALPAA9MYQ4, ABDH_SALPB
C0Q4N4, ABDH_SALPCQ8Z747, ABDH_SALTIQ8ZPC9, ABDH_SALTY
A8GHZ8, ABDH_SERP5Q32FQ5, ABDH_SHIDSQ0T431, ABDH_SHIF8
Q83R90, ABDH_SHIFLQ3Z1H6, ABDH_SHISSC0P9J6, ADH1A_MAIZE
G5DDC2, ADH1B_MAIZEP48644, AL1A1_BOVINP27463, AL1A1_CHICK
P15437, AL1A1_HORSEP00352, AL1A1_HUMANQ8HYE4, AL1A1_MACFA
P86886, AL1A1_MESAUP24549, AL1A1_MOUSEQ8MI17, AL1A1_RABIT
P51647, AL1A1_RATP51977, AL1A1_SHEEPQ2KJH9, AL9A1_BOVIN
P49189, AL9A1_HUMANQ9JLJ2, AL9A1_MOUSEQ29228, AL9A1_PIG
Q5R8A4, AL9A1_PONABQ9JLJ3, AL9A1_RATQ9S795, BADH1_ARATH
Q9STS1, BADH2_ARATHP17202, BADH_SPIOL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-