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ENZYME

ENZYME entry: EC 1.2.1.27

PURL: https://purl.expasy.org/enzyme/EC/1.2.1.27
Accepted Name
methylmalonate-semialdehyde dehydrogenase (CoA acylating)
Alternative Name(s)
methylmalonate-semialdehyde dehydrogenase (acylating)
MMSA dehydrogenase
MSDH
Reaction catalysed
2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)
Comment(s)
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO2 is released as a final product.
Cross-references
BRENDA1.2.1.27
EC2PDB1.2.1.27
ExplorEnz1.2.1.27
KEGG Ligand Database for Enzyme Nomenclature1.2.1.27
IUBMB Enzyme Nomenclature1.2.1.27
MEDLINEFind literature relating to 1.2.1.27
MetaCyc1.2.1.27
Rhea expert-curated reactions1.2.1.27
UniProtKB/Swiss-Prot
Q9I702, BAUC_PSEAEA0RDW1, IOLA1_BACAHQ81QR5, IOLA1_BACAN
Q63BL0, IOLA1_BACCZQ6HJ19, IOLA1_BACHKQ65IX1, IOLA1_BACLD
A9VF06, IOLA1_BACMKQ5L025, IOLA1_GEOKAA4IPB2, IOLA1_GEOTN
Q8ES27, IOLA1_OCEIHQ5WKZ1, IOLA1_SHOC1A0REB5, IOLA2_BACAH
Q81QB6, IOLA2_BACANQ63B74, IOLA2_BACCZQ6HIK3, IOLA2_BACHK
Q65D00, IOLA2_BACLDA9VMS6, IOLA2_BACMKQ5KYR4, IOLA2_GEOKA
A4IPF5, IOLA2_GEOTNQ8EMV4, IOLA2_OCEIHQ5WH11, IOLA2_SHOC1
Q4V1F6, IOLA3_BACCZQ5KYK0, IOLA3_GEOKAQ738L2, IOLA_BACC1
B7IW48, IOLA_BACC2B7H597, IOLA_BACC4B7HR31, IOLA_BACC7
A7GPH3, IOLA_BACCNB9IZZ7, IOLA_BACCQQ81DR5, IOLA_BACCR
A7BJC4, IOLA_BACNAA8FDV4, IOLA_BACP2P42412, IOLA_BACSU
A7ZAI1, IOLA_BACVZQ9KAH5, IOLA_HALH5A5YBJ3, IOLA_LACCA
Q92EQ7, IOLA_LISINC1KZ99, IOLA_LISMCQ723T1, IOLA_LISMF
B8DCT8, IOLA_LISMHQ8Y9Y4, IOLA_LISMOQ17M80, MMSA_AEDAE
Q7QC84, MMSA_ANOGAQ0WM29, MMSA_ARATHQ07536, MMSA_BOVIN
P52713, MMSA_CAEELQ54I10, MMSA_DICDIQ7KW39, MMSA_DROME
Q29HB2, MMSA_DROPSQ02252, MMSA_HUMANQ9EQ20, MMSA_MOUSE
P28810, MMSA_PSEAEQ02253, MMSA_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-