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ENZYME entry: EC 1.2.1.27

Accepted Name
methylmalonate-semialdehyde dehydrogenase (CoA acylating).
Alternative Name(s)
methylmalonate-semialdehyde dehydrogenase (acylating).
MMSA dehydrogenase.
MSDH.
Reaction catalysed
2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA
Comment(s)
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO2 is released as a final product.
Cross-references
BRENDA1.2.1.27
EC2PDB1.2.1.27
ExplorEnz1.2.1.27
PRIAM enzyme-specific profiles1.2.1.27
KEGG Ligand Database for Enzyme Nomenclature1.2.1.27
IUBMB Enzyme Nomenclature1.2.1.27
IntEnz1.2.1.27
MEDLINEFind literature relating to 1.2.1.27
MetaCyc1.2.1.27
Rhea expert-curated reactions1.2.1.27
UniProtKB/Swiss-Prot
Q5WKZ1, IOLA1_ALKCK;  A0RDW1, IOLA1_BACAH;  Q81QR5, IOLA1_BACAN;  
Q63BL0, IOLA1_BACCZ;  Q6HJ19, IOLA1_BACHK;  Q65IX1, IOLA1_BACLD;  
A9VF06, IOLA1_BACMK;  Q5L025, IOLA1_GEOKA;  A4IPB2, IOLA1_GEOTN;  
Q8ES27, IOLA1_OCEIH;  Q5WH11, IOLA2_ALKCK;  A0REB5, IOLA2_BACAH;  
Q81QB6, IOLA2_BACAN;  Q63B74, IOLA2_BACCZ;  Q6HIK3, IOLA2_BACHK;  
Q65D00, IOLA2_BACLD;  A9VMS6, IOLA2_BACMK;  Q5KYR4, IOLA2_GEOKA;  
A4IPF5, IOLA2_GEOTN;  Q8EMV4, IOLA2_OCEIH;  Q4V1F6, IOLA3_BACCZ;  
Q5KYK0, IOLA3_GEOKA;  Q738L2, IOLA_BACC1;  B7IW48, IOLA_BACC2;  
B7H597, IOLA_BACC4;  B7HR31, IOLA_BACC7;  A7GPH3, IOLA_BACCN;  
B9IZZ7, IOLA_BACCQ;  Q81DR5, IOLA_BACCR;  A7BJC4, IOLA_BACNA;  
A8FDV4, IOLA_BACP2;  P42412, IOLA_BACSU;  A7ZAI1, IOLA_BACVZ;  
Q9KAH5, IOLA_HALH5;  A5YBJ3, IOLA_LACCA;  Q92EQ7, IOLA_LISIN;  
C1KZ99, IOLA_LISMC;  Q723T1, IOLA_LISMF;  B8DCT8, IOLA_LISMH;  
Q8Y9Y4, IOLA_LISMO;  Q17M80, MMSA_AEDAE;  Q7QC84, MMSA_ANOGA;  
Q0WM29, MMSA_ARATH;  Q07536, MMSA_BOVIN;  P52713, MMSA_CAEEL;  
Q54I10, MMSA_DICDI;  Q7KW39, MMSA_DROME;  Q29HB2, MMSA_DROPS;  
Q02252, MMSA_HUMAN;  Q9EQ20, MMSA_MOUSE;  P28810, MMSA_PSEAE;  
Q02253, MMSA_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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