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ENZYME

ENZYME entry: EC 1.2.1.27

Accepted Name
methylmalonate-semialdehyde dehydrogenase (CoA acylating)
Alternative Name(s)
methylmalonate-semialdehyde dehydrogenase (acylating)
MMSA dehydrogenase
MSDH
Reaction catalysed
2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) <=> H(+) + hydrogencarbonate + NADH + propanoyl-CoA
Comment(s)
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO2 is released as a final product.
Cross-references
BRENDA1.2.1.27
EC2PDB1.2.1.27
ExplorEnz1.2.1.27
PRIAM enzyme-specific profiles1.2.1.27
KEGG Ligand Database for Enzyme Nomenclature1.2.1.27
IUBMB Enzyme Nomenclature1.2.1.27
IntEnz1.2.1.27
MEDLINEFind literature relating to 1.2.1.27
MetaCyc1.2.1.27
Rhea expert-curated reactions1.2.1.27
UniProtKB/Swiss-Prot
Q5WKZ1, IOLA1_ALKCKA0RDW1, IOLA1_BACAHQ81QR5, IOLA1_BACAN
Q63BL0, IOLA1_BACCZQ6HJ19, IOLA1_BACHKQ65IX1, IOLA1_BACLD
A9VF06, IOLA1_BACMKQ5L025, IOLA1_GEOKAA4IPB2, IOLA1_GEOTN
Q8ES27, IOLA1_OCEIHQ5WH11, IOLA2_ALKCKA0REB5, IOLA2_BACAH
Q81QB6, IOLA2_BACANQ63B74, IOLA2_BACCZQ6HIK3, IOLA2_BACHK
Q65D00, IOLA2_BACLDA9VMS6, IOLA2_BACMKQ5KYR4, IOLA2_GEOKA
A4IPF5, IOLA2_GEOTNQ8EMV4, IOLA2_OCEIHQ4V1F6, IOLA3_BACCZ
Q5KYK0, IOLA3_GEOKAQ738L2, IOLA_BACC1B7IW48, IOLA_BACC2
B7H597, IOLA_BACC4B7HR31, IOLA_BACC7A7GPH3, IOLA_BACCN
B9IZZ7, IOLA_BACCQQ81DR5, IOLA_BACCRA7BJC4, IOLA_BACNA
A8FDV4, IOLA_BACP2P42412, IOLA_BACSUA7ZAI1, IOLA_BACVZ
Q9KAH5, IOLA_HALH5A5YBJ3, IOLA_LACCAQ92EQ7, IOLA_LISIN
C1KZ99, IOLA_LISMCQ723T1, IOLA_LISMFB8DCT8, IOLA_LISMH
Q8Y9Y4, IOLA_LISMOQ17M80, MMSA_AEDAEQ7QC84, MMSA_ANOGA
Q0WM29, MMSA_ARATHQ07536, MMSA_BOVINP52713, MMSA_CAEEL
Q54I10, MMSA_DICDIQ7KW39, MMSA_DROMEQ29HB2, MMSA_DROPS
Q02252, MMSA_HUMANQ9EQ20, MMSA_MOUSEP28810, MMSA_PSEAE
Q02253, MMSA_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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