ID 1.2.1.30 DE carboxylate reductase (NADP(+)). AN aryl-aldehyde dehydrogenase (NADP(+)). CA AMP + an aromatic aldehyde + diphosphate + NADP(+) = an aromatic CA carboxylate + ATP + H(+) + NADPH. CC -!- The enzyme contains an adenylation domain, a phosphopantetheinyl CC binding domain, and a reductase domain, and requires activation by CC attachment of a phosphopantetheinyl group. CC -!- The enzyme activates its substrate to an adenylate form, followed by CC a transfer to the phosphopantetheinyl binding domain. CC -!- The resulting thioester is subsequently transferred to the reductase CC domain, where it is reduced to an aldehyde and released. DR Q7RW48, CAR_NEUCR ; Q6RKB1, CAR_NOCIO ; //