ENZYME entry: EC 1.2.1.31
Accepted Name |
L-aminoadipate-semialdehyde dehydrogenase.
|
Alternative Name(s) |
2-aminoadipate semialdehyde dehydrogenase. |
2-aminoadipic semialdehyde dehydrogenase. |
Alpha-aminoadipate reductase. |
Alpha-aminoadipate-semialdehyde dehydrogenase. |
Aminoadipate semialdehyde dehydrogenase. |
L-alpha-aminoadipate delta-semialdehyde oxidoreductase. |
Reaction catalysed |
(S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O <=> L-2-aminoadipate + NAD(P)H |
Comment(s) |
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration
forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate,
which serves as a substrate for the hydrogenation reaction.
|
Cross-references |
PROSITE | PDOC00427 |
BRENDA | 1.2.1.31 |
EC2PDB | 1.2.1.31 |
ExplorEnz | 1.2.1.31 |
PRIAM enzyme-specific profiles | 1.2.1.31 |
KEGG Ligand Database for Enzyme Nomenclature | 1.2.1.31 |
IUBMB Enzyme Nomenclature | 1.2.1.31 |
IntEnz | 1.2.1.31 |
MEDLINE | Find literature relating to 1.2.1.31 |
MetaCyc | 1.2.1.31 |
UniProtKB/Swiss-Prot |
P83402, AL7A1_ACASC; | Q2KJC9, AL7A1_BOVIN; | P84463, AL7A1_CTEID; |
P49419, AL7A1_HUMAN; | Q9DBF1, AL7A1_MOUSE; | Q64057, AL7A1_RAT; |
Q75BB3, LYS2_ASHGO; | Q12572, LYS2_CANAX; | Q6FMI5, LYS2_CANGA; |
O74298, LYS2_PENCH; | P40976, LYS2_SCHPO; | P07702, LYS2_YEAST; |
|
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