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ENZYME

ENZYME entry: EC 1.2.1.31

PURL: https://purl.expasy.org/enzyme/EC/1.2.1.31
Accepted Name
L-aminoadipate-semialdehyde dehydrogenase
Alternative Name(s)
2-aminoadipate semialdehyde dehydrogenase
2-aminoadipic semialdehyde dehydrogenase
alpha-aminoadipate reductase
alpha-aminoadipate-semialdehyde dehydrogenase
aminoadipate semialdehyde dehydrogenase
L-alpha-aminoadipate delta-semialdehyde oxidoreductase
Reaction catalysed
  • (S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)
  • (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
Comment(s)
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
Cross-references
BRENDA1.2.1.31
EC2PDB1.2.1.31
ExplorEnz1.2.1.31
KEGG Ligand Database for Enzyme Nomenclature1.2.1.31
IUBMB Enzyme Nomenclature1.2.1.31
MEDLINEFind literature relating to 1.2.1.31
MetaCyc1.2.1.31
Rhea expert-curated reactions1.2.1.31
UniProtKB/Swiss-Prot
P83402, AL7A1_ACASCQ2KJC9, AL7A1_BOVINP84463, AL7A1_CTEID
P49419, AL7A1_HUMANQ9DBF1, AL7A1_MOUSEQ64057, AL7A1_RAT
Q12572, LYS2_CANAXQ6FMI5, LYS2_CANGAQ75BB3, LYS2_EREGS
O74298, LYS2_PENCHP40976, LYS2_SCHPOP07702, LYS2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-