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ENZYME entry: EC 1.2.1.31

Accepted Name
L-aminoadipate-semialdehyde dehydrogenase.
Alternative Name(s)
2-aminoadipate semialdehyde dehydrogenase.
2-aminoadipic semialdehyde dehydrogenase.
Alpha-aminoadipate reductase.
Alpha-aminoadipate-semialdehyde dehydrogenase.
Aminoadipate semialdehyde dehydrogenase.
L-alpha-aminoadipate delta-semialdehyde oxidoreductase.
Reaction catalysed
(S)-2-amino-6-oxohexanoate + NAD(P)(+) + H(2)O <=> L-2-aminoadipate + NAD(P)H
Comment(s)
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
Cross-references
PROSITEPDOC00427
BRENDA1.2.1.31
EC2PDB1.2.1.31
ExplorEnz1.2.1.31
PRIAM enzyme-specific profiles1.2.1.31
KEGG Ligand Database for Enzyme Nomenclature1.2.1.31
IUBMB Enzyme Nomenclature1.2.1.31
IntEnz1.2.1.31
MEDLINEFind literature relating to 1.2.1.31
MetaCyc1.2.1.31
Rhea expert-curated reactions1.2.1.31
UniProtKB/Swiss-Prot
P83402, AL7A1_ACASC;  Q2KJC9, AL7A1_BOVIN;  P84463, AL7A1_CTEID;  
P49419, AL7A1_HUMAN;  Q9DBF1, AL7A1_MOUSE;  Q64057, AL7A1_RAT;  
Q75BB3, LYS2_ASHGO;  Q12572, LYS2_CANAX;  Q6FMI5, LYS2_CANGA;  
O74298, LYS2_PENCH;  P40976, LYS2_SCHPO;  P07702, LYS2_YEAST;  

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