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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.2.1.51

Accepted Name
Pyruvate dehydrogenase (NADP(+)).
Alternative Name(s)
Pyruvate:NADP(+) oxidoreductase.
Reaction catalysed
Pyruvate + CoA + NADP(+) <=> acetyl-CoA + CO(2) + NADPH
Comment(s)
  • The Euglena enzyme can also use FAD or methylviologen as acceptor, more slowly.
  • Inhibited by oxygen.
Cross-references
BRENDA1.2.1.51
EC2PDB1.2.1.51
ExplorEnz1.2.1.51
PRIAM enzyme-specific profiles1.2.1.51
KEGG Ligand Database for Enzyme Nomenclature1.2.1.51
IUBMB Enzyme Nomenclature1.2.1.51
IntEnz1.2.1.51
MEDLINEFind literature relating to 1.2.1.51
MetaCyc1.2.1.51
UniProtKB/Swiss-Prot
Q968X7, PNO_CRYPV;  Q94IN5, PNO_EUGGR;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-