ID 1.2.1.76 DE succinate-semialdehyde dehydrogenase (acetylating). AN coenzyme-A-dependent succinate-semialdehyde dehydrogenase. AN succinyl-CoA reductase. CA succinate semialdehyde + NADP(+) + CoA = succinyl-CoA + NADPH + H(+). CC -!- Catalyzes the NADPH-dependent reduction of succinyl-CoA to succinate CC semialdehyde. CC -!- The enzyme has been described in Clostridium kluyveri, where it CC participates in succinate fermentation, and in Metallosphaera sedula, CC where it participates in the 3-hydroxypropanoate/4-hydroxybutyrate CC cycle, an autotrophic CO2 fixation pathway found in some CC thermoacidophilic archaea. DR P38947, SUCD_CLOK5 ; A4YGN0, SUCD_METS5 ; //