A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.2.1.84

Accepted Name
Alcohol-forming fatty acyl-CoA reductase.
Reaction catalysed
A long-chain acyl-CoA + 2 NADPH <=> CoA + a long-chain alcohol + 2 NADP(+)
Comment(s)
  • The enzyme has been characterized from the plant Simmondsia chinensis (jojoba).
  • The alcohol is formed by a four-electron reduction of fatty acyl-CoA.
  • Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released.
  • The recombinant enzyme was shown to accept saturated and mono- unsaturated fatty acyl-CoAs of 16 to 22 carbons.
Cross-references
BRENDA1.2.1.84
EC2PDB1.2.1.84
ExplorEnz1.2.1.84
PRIAM enzyme-specific profiles1.2.1.84
KEGG Ligand Database for Enzyme Nomenclature1.2.1.84
IUBMB Enzyme Nomenclature1.2.1.84
IntEnz1.2.1.84
MEDLINEFind literature relating to 1.2.1.84
MetaCyc1.2.1.84
UniProtKB/Swiss-Prot
Q39152, FACR1_ARATH;  Q5ZM72, FACR1_CHICK;  A1ZAI5, FACR1_DROME;  
Q8WVX9, FACR1_HUMAN;  Q922J9, FACR1_MOUSE;  Q5R834, FACR1_PONAB;  
Q66H50, FACR1_RAT;  Q7ZXF5, FACR1_XENLA;  Q08891, FACR2_ARATH;  
Q0P5J1, FACR2_BOVIN;  A1ZAI3, FACR2_DROME;  Q96K12, FACR2_HUMAN;  
Q7TNT2, FACR2_MOUSE;  Q93ZB9, FACR3_ARATH;  Q960W6, FACR3_DROME;  
Q9LXN3, FACR4_ARATH;  Q0WRB0, FACR5_ARATH;  B9TSP7, FACR6_ARATH;  
Q1PEI6, FACR8_ARATH;  Q9XGY7, FAR_SIMCH;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-