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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2-hydroxymuconate-6-semialdehyde dehydrogenase.
Reaction catalysed
2-hydroxymuconate-6-semialdehyde + NAD(+) + H(2)O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH
  • This substrate for this enzyme is formed by meta ring cleavage of catechol (EC, and is an intermediate in the bacterial degradation of several aromatic compounds.
  • Has lower activity with benzaldehyde.
  • Activity with NAD(+) is more than 10-fold higher than with NADP(+).
  • Cf. EC
PRIAM enzyme-specific profiles1.2.1.85
KEGG Ligand Database for Enzyme Nomenclature1.2.1.85
IUBMB Enzyme Nomenclature1.2.1.85
MEDLINEFind literature relating to
P19059, DMPC_PSEUF;  P23105, XYLG_PSEPU;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-