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ENZYME entry: EC 1.2.1.85

Accepted Name
2-hydroxymuconate-6-semialdehyde dehydrogenase.
Reaction catalysed
(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O + NAD(+) <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+) + NADH
Comment(s)
  • This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2), and is an intermediate in the bacterial degradation of several aromatic compounds.
  • Has lower activity with benzaldehyde.
  • Activity with NAD(+) is more than 10-fold higher than with NADP(+).
  • Cf. EC 1.2.1.32.
Cross-references
BRENDA1.2.1.85
EC2PDB1.2.1.85
ExplorEnz1.2.1.85
PRIAM enzyme-specific profiles1.2.1.85
KEGG Ligand Database for Enzyme Nomenclature1.2.1.85
IUBMB Enzyme Nomenclature1.2.1.85
IntEnz1.2.1.85
MEDLINEFind literature relating to 1.2.1.85
MetaCyc1.2.1.85
Rhea expert-curated reactions1.2.1.85
UniProtKB/Swiss-Prot
P19059, DMPC_PSEUF;  P23105, XYLG_PSEPU;  

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