ENZYME entry: EC 1.2.1.85
| Accepted Name |
|---|
| 2-hydroxymuconate-6-semialdehyde dehydrogenase.
|
| Reaction catalysed |
|---|
| 2-hydroxymuconate-6-semialdehyde + NAD(+) + H(2)O <=> (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH |
| Comment(s) |
|---|
- This substrate for this enzyme is formed by meta ring cleavage of
catechol (EC 1.13.11.2), and is an intermediate in the bacterial
degradation of several aromatic compounds.
- Has lower activity with benzaldehyde.
- Activity with NAD(+) is more than 10-fold higher than with NADP(+).
- Cf. EC 1.2.1.32.
|
| Cross-references |
|---|
| BRENDA | 1.2.1.85 |
| EC2PDB | 1.2.1.85 |
| ExplorEnz | 1.2.1.85 |
| PRIAM enzyme-specific profiles | 1.2.1.85 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.1.85 |
| IUBMB Enzyme Nomenclature | 1.2.1.85 |
| IntEnz | 1.2.1.85 |
| MEDLINE | Find literature relating to 1.2.1.85 |
| MetaCyc | 1.2.1.85 |
| UniProtKB/Swiss-Prot |
|
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