ID   1.2.1.88
DE   L-glutamate gamma-semialdehyde dehydrogenase.
AN   1-pyrroline-5-carboxylate dehydrogenase.
AN   Delta(1)-pyrroline-5-carboxylate dehydrogenase.
AN   pyrroline-5-carboxylate dehydrogenase.
CA   H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH.
CC   -!- This enzyme catalyzes the irreversible oxidation of glutamate-gamma-
CC       semialdehyde to glutamate as part of the proline degradation pathway.
CC   -!- (S)-1-pyrroline-5-carboxylate, the product of the first enzyme of the
CC       pathway (EC 1.5.5.2) is in spontaneous equilibrium with its tautomer
CC       L-glutamate gamma-semialdehyde.
CC   -!- In many bacterial species, both activities are carried out by a
CC       single bifunctional enzyme.
CC   -!- The enzyme can also oxidize other 1-pyrrolines, e.g. 3-hydroxy-1-
CC       pyrroline-5-carboxylate is converted into 4-hydroxyglutamate and (R)-
CC       1-pyrroline-5-carboxylate is converted into D-glutamate.
CC   -!- NADP(+) can also act as acceptor, but with lower activity.
CC   -!- Formerly EC 1.5.1.12.
DR   Q8VZC3, AL121_ARATH;  A7YWE4, AL4A1_BOVIN;  Q7SY23, AL4A1_DANRE;
DR   Q54RA2, AL4A1_DICDI;  P30038, AL4A1_HUMAN;  Q8CHT0, AL4A1_MOUSE;
DR   P0C2X9, AL4A1_RAT  ;  P78568, PUT2_AGABI ;  Q9P8I0, PUT2_EMENI ;
DR   O74766, PUT2_SCHPO ;  P07275, PUT2_YEAST ;  P09546, PUTA_ECOLI ;
DR   O52485, PUTA_KLEAE ;  P23725, PUTA_KLEPN ;  P95629, PUTA_RHIML ;
DR   P10503, PUTA_SALTY ;  Q9K9B2, ROCA1_HALH5;  P94391, ROCA2_BACSU;
DR   Q9K5Z5, ROCA2_HALH5;  B7GFV3, ROCA_ANOFW ;  C3PBP4, ROCA_BACAA ;
DR   C3L546, ROCA_BACAC ;  A0R909, ROCA_BACAH ;  Q81ZF8, ROCA_BACAN ;
DR   B7JM99, ROCA_BACC0 ;  P62028, ROCA_BACC1 ;  B7IUW8, ROCA_BACC2 ;
DR   C1EV77, ROCA_BACC3 ;  B7H4V1, ROCA_BACC4 ;  B7HSW8, ROCA_BACC7 ;
DR   A7GKJ4, ROCA_BACCN ;  B9J1L9, ROCA_BACCQ ;  Q81IP0, ROCA_BACCR ;
DR   Q63GS0, ROCA_BACCZ ;  Q6HP91, ROCA_BACHK ;  Q65NN2, ROCA_BACLD ;
DR   A9VRG6, ROCA_BACMK ;  A8F9T1, ROCA_BACP2 ;  P39634, ROCA_BACSU ;
DR   Q5L3K8, ROCA_GEOKA ;  C5D4J5, ROCA_GEOSW ;  A4IJP9, ROCA_GEOTN ;
DR   Q8ERF4, ROCA_OCEIH ;  A7X6R7, ROCA_STAA1 ;  A6U4T5, ROCA_STAA2 ;
DR   Q2FDV3, ROCA_STAA3 ;  Q2FV67, ROCA_STAA8 ;  A5IVY0, ROCA_STAA9 ;
DR   Q2YWA6, ROCA_STAAB ;  Q5HCZ6, ROCA_STAAC ;  A6QK44, ROCA_STAAE ;
DR   P63939, ROCA_STAAM ;  P99076, ROCA_STAAN ;  Q6GDP4, ROCA_STAAR ;
DR   Q6G6C0, ROCA_STAAS ;  A8Z3F5, ROCA_STAAT ;  Q8NUR2, ROCA_STAAW ;
DR   Q5HL59, ROCA_STAEQ ;  Q8CN04, ROCA_STAES ;  Q4L966, ROCA_STAHJ ;
DR   Q4A0E7, ROCA_STAS1 ;
//