ID   1.2.1.95
DE   L-2-aminoadipate reductase.
AN   alpha-aminoadipate reductase.
CA   (S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = ATP + H(+) +
CA   L-2-aminoadipate + NADPH.
CC   -!- This enzyme, characterized from the yeast Saccharomyces cerevisiae,
CC       catalyzes the reduction of L-2-aminoadipate to (S)-2-amino-6-
CC       oxohexanoate during L-lysine biosynthesis.
CC   -!- An adenylation domain activates the substrate at the expense of ATP
CC       hydrolysis, and forms L-2-aminoadipate adenylate, which is attached
CC       to a peptidyl-carrier protein (PCP) domain.
CC   -!- Binding of NADPH results in reductive cleavage of the acyl-S-enzyme
CC       intermediate, releasing (S)-2-amino-6-oxohexanoate.
CC   -!- Different from EC 1.2.1.31 which catalyzes a similar transformation
CC       in the opposite direction without ATP hydrolysis.
DR   Q12572, LYS2_CANAX ;  Q6FMI5, LYS2_CANGA ;  Q75BB3, LYS2_EREGS ;
DR   O74298, LYS2_PENCH ;  P40976, LYS2_SCHPO ;  P07702, LYS2_YEAST ;
//