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ENZYME

ENZYME entry: EC 1.2.3.1

Accepted Name
aldehyde oxidase
Alternative Name(s)
quinoline oxidase
retinal oxidase
Reaction catalysed
an aldehyde + H2O + O2 = a carboxylate + H(+) + H2O2
Comment(s)
  • The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides.
  • The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11).
  • Formerly EC 1.2.3.11.
Cross-references
BRENDA1.2.3.1
EC2PDB1.2.3.1
ExplorEnz1.2.3.1
PRIAM enzyme-specific profiles1.2.3.1
KEGG Ligand Database for Enzyme Nomenclature1.2.3.1
IUBMB Enzyme Nomenclature1.2.3.1
IntEnz1.2.3.1
MEDLINEFind literature relating to 1.2.3.1
MetaCyc1.2.3.1
Rhea expert-curated reactions1.2.3.1
UniProtKB/Swiss-Prot
Q7XH05, ALDO1_ORYSJQ852M1, ALDO2_ORYSJQ852M2, ALDO3_ORYSJ
Q7G191, ALDO4_ARATHQ69R21, ALDO4_ORYSJP48034, AOXA_BOVIN
H9TB17, AOXA_CAVPOQ06278, AOXA_HUMANQ5FB27, AOXA_MACFA
O54754, AOXA_MOUSEP80456, AOXA_RABITQ9Z0U5, AOXA_RAT
H9TB19, AOXB_CAVPOC4NYZ3, AOXB_MACFAQ5SGK3, AOXB_MOUSE
Q5QE78, AOXB_RATG3X982, AOXC_MOUSEQ5QE80, AOXC_RAT
H9TB18, AOXD_CAVPOQ3TYQ9, AOXD_MOUSEQ5QE79, AOXD_RAT
Q960A1, GAD3_CAEELQ9FYG4, GLOX1_ARATHA0A2H4HHY6, GLOX_ARTAN
Q3HRQ2, GLOX_VITPS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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