ID   1.2.7.1
DE   pyruvate synthase.
AN   2-oxobutyrate-ferredoxin oxidoreductase.
AN   2-oxobutyrate synthase.
AN   alpha-ketobutyrate-ferredoxin oxidoreductase.
AN   alpha-ketobutyrate synthase.
AN   pyruvate oxidoreductase.
AN   pyruvate synthetase.
AN   pyruvic-ferredoxin oxidoreductase.
CA   2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate + CoA = 2 reduced [2Fe-2S]-
CA   [ferredoxin] + acetyl-CoA + CO2 + H(+).
CC   -!- Contains thiamine diphosphate and [4Fe-4S] clusters.
CC   -!- The enzyme, common in bacteria, archaea, and some algae, catalyzes
CC       the reversible decarboxylation of pyruvate with the formation of
CC       acetyl-CoA.
CC   -!- Enzymes from different organisms catalyze the reaction in different
CC       directions depending on their metabolic needs.
CC   -!- The enzyme also decarboxylates 2-oxobutanoate with lower efficiency,
CC       but shows no activity with 2-oxoglutarate.
CC   -!- In some organisms ferredoxin may be replaced by the flavin
CC       mononucleotide (FMN)-containing flavodoxin under conditions of low
CC       iron and high oxygen (cf. EC 1.2.8.1).
CC   -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of
CC       enzymes that oxidatively decarboxylate different 2-oxoacids to form
CC       their CoA derivatives, and are differentiated based on their
CC       substrate specificity.
CC   -!- For examples of other members of this family, see EC 1.2.7.3 and
CC       EC 1.2.7.7.
DR   P94692, PFOR_DESAF ;  Q2RMD6, PFOR_MOOTA ;  P80521, PORA_METBF ;
DR   Q57715, PORA_METJA ;  P56810, PORA_METTH ;  P80900, PORA_METTM ;
DR   Q9UYZ4, PORA_PYRAB ;  Q51804, PORA_PYRFU ;  O73986, PORA_PYRHO ;
DR   O05651, PORA_THEMA ;  P80522, PORB_METBF ;  Q57714, PORB_METJA ;
DR   O27771, PORB_METTH ;  P80901, PORB_METTM ;  Q9UYZ5, PORB_PYRAB ;
DR   Q51805, PORB_PYRFU ;  O58417, PORB_PYRHO ;  Q56317, PORB_THEMA ;
DR   P80523, PORC_METBF ;  Q57717, PORC_METJA ;  O27772, PORC_METTH ;
DR   P80902, PORC_METTM ;  Q9UYY9, PORC_PYRAB ;  P84819, PORC_PYREN ;
DR   Q51799, PORC_PYRFU ;  O58411, PORC_PYRHO ;  Q5JIK2, PORC_THEKO ;
DR   P84820, PORC_THELN ;  O05650, PORC_THEMA ;
//