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ENZYME

ENZYME entry: EC 1.2.7.12

PURL: https://purl.expasy.org/enzyme/EC/1.2.7.12
Accepted Name
formylmethanofuran dehydrogenase
Reaction catalysed
N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)
Comment(s)
  • The enzyme catalyzes a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2.
  • The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
  • Formerly EC 1.2.99.5.
Cross-references
BRENDA1.2.7.12
EC2PDB1.2.7.12
ExplorEnz1.2.7.12
KEGG Ligand Database for Enzyme Nomenclature1.2.7.12
IUBMB Enzyme Nomenclature1.2.7.12
MEDLINEFind literature relating to 1.2.7.12
MetaCyc1.2.7.12
Rhea expert-curated reactions1.2.7.12
UniProtKB/Swiss-Prot
Q48943, FMDC_METBFO27002, FMDC_METTHP61937, FMDC_METTM
P61938, FMDC_METWOP61154, FWDB_METJAQ6LWL8, FWDB_METMP
Q58571, FWDC_METJAP0CW42, FWDC_METMIP0CW43, FWDC_METMP
O27600, FWDC_METTHQ59579, FWDC_METTMO74031, FWDC_METWO
Q49611, FWDG_METKA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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