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ENZYME entry: EC 1.2.7.12

Accepted Name
Formylmethanofuran dehydrogenase.
Reaction catalysed
Formylmethanofuran + H(2)O + 2 oxidized ferredoxin [iron-sulfur] cluster <=> CO(2) + methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+)
Cofactor(s)
Mo cation.
Comment(s)
  • The enzyme catalyzes a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO(2) as well as the oxidation of coenzyme M to CO(2).
  • The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
  • Formerly EC 1.2.99.5.
Cross-references
BRENDA1.2.7.12
EC2PDB1.2.7.12
ExplorEnz1.2.7.12
PRIAM enzyme-specific profiles1.2.7.12
KEGG Ligand Database for Enzyme Nomenclature1.2.7.12
IUBMB Enzyme Nomenclature1.2.7.12
IntEnz1.2.7.12
MEDLINEFind literature relating to 1.2.7.12
MetaCyc1.2.7.12
UniProtKB/Swiss-Prot
Q48943, FMDC_METBF;  O27002, FMDC_METTH;  P61937, FMDC_METTM;  
P61938, FMDC_METWO;  P61154, FWDB_METJA;  Q6LWL8, FWDB_METMP;  
Q58571, FWDC_METJA;  P0CW42, FWDC_METMI;  P0CW43, FWDC_METMP;  
O27600, FWDC_METTH;  Q59579, FWDC_METTM;  O74031, FWDC_METWO;  
Q49611, FWDG_METKA;  

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