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ENZYME entry: EC 1.2.7.4

Accepted Name
Anaerobic carbon-monoxide dehydrogenase.
Alternative Name(s)
Carbon-monoxide dehydrogenase (ferredoxin).
Ni-CODH.
Reaction catalysed
CO + H(2)O + 2 oxidized ferredoxin <=> CO(2) + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Fe cation; Ni(2+); Zn(2+).
Comment(s)
  • This prokaryotic enzyme catalyzes the reversible reduction of CO(2) to CO.
  • The electrons are transferred to redox proteins such as ferredoxin.
  • In purple sulfur bacteria and methanogenic archaea it catalyzes the oxidation of CO to CO(2), which is incorporated by the Calvin-Benson- Basham cycle or released, respectively.
  • In acetogenic and sulfate-reducing microbes it catalyzes the reduction of CO(2) to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, with which the enzyme forms a tight complex in those organisms.
  • In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O = CO(2) + H(2).
  • Cf. EC 1.2.5.3.
  • Formerly EC 1.2.99.2.
Cross-references
BRENDA1.2.7.4
EC2PDB1.2.7.4
ExplorEnz1.2.7.4
PRIAM enzyme-specific profiles1.2.7.4
KEGG Ligand Database for Enzyme Nomenclature1.2.7.4
IUBMB Enzyme Nomenclature1.2.7.4
IntEnz1.2.7.4
MEDLINEFind literature relating to 1.2.7.4
MetaCyc1.2.7.4
Rhea expert-curated reactions1.2.7.4
UniProtKB/Swiss-Prot
O29165, ACDA1_ARCFU;  Q8TRZ4, ACDA1_METAC;  Q46G04, ACDA1_METBF;  
Q8TXF7, ACDA1_METKA;  Q49161, ACDA1_METMA;  Q08368, ACDA1_METTE;  
O30274, ACDA2_ARCFU;  Q8TJC6, ACDA2_METAC;  Q49163, ACDA2_METMA;  
Q9C4Z4, ACDA2_METTE;  Q8THW2, ACDA3_METAC;  Q12XL7, ACDA_METBU;  
Q57617, ACDA_METJA;  P26692, ACDA_METSH;  O27743, ACDA_METTH;  
P59934, COOS1_CARHZ;  Q8TKW2, COOS1_METAC;  Q8Q0L5, COOS1_METMA;  
Q9F8A8, COOS2_CARHZ;  Q8TR73, COOS2_METAC;  Q8PUN1, COOS2_METMA;  
O28429, COOS_ARCFU;  Q58138, COOS_METJA;  Q8TXX3, COOS_METKA;  
P31896, COOS_RHORU;  P27989, DCMB_MOOTH;  

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