A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.2.7.4
| Accepted Name |
|---|
| Anaerobic carbon-monoxide dehydrogenase.
|
| Alternative Name(s) |
|---|
| Carbon-monoxide dehydrogenase (ferredoxin). |
| Ni-CODH. |
| Reaction catalysed |
|---|
| CO + H(2)O + 2 oxidized ferredoxin <=> CO(2) + 2 reduced ferredoxin + 2 H(+) |
| Cofactor(s) |
|---|
| Fe cation; Ni(2+); Zn(2+).
|
| Comment(s) |
|---|
- This prokaryotic enzyme catalyzes the reversible reduction of CO(2)
to CO.
- The electrons are transferred to redox proteins such as ferredoxin.
- In purple sulfur bacteria and methanogenic archaea it catalyzes the
oxidation of CO to CO(2), which is incorporated by the Calvin-Benson-
Basham cycle or released, respectively.
- In acetogenic and sulfate-reducing microbes it catalyzes the
reduction of CO(2) to CO, which is incorporated into acetyl CoA by
EC 2.3.1.169, with which the enzyme forms a tight complex in those
organisms.
- In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S
protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O =
CO(2) + H(2).
- Cf. EC 1.2.5.3.
- Formerly EC 1.2.99.2.
|
| Cross-references |
|---|
| BRENDA | 1.2.7.4 |
| EC2PDB | 1.2.7.4 |
| ExplorEnz | 1.2.7.4 |
| PRIAM enzyme-specific profiles | 1.2.7.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.7.4 |
| IUBMB Enzyme Nomenclature | 1.2.7.4 |
| IntEnz | 1.2.7.4 |
| MEDLINE | Find literature relating to 1.2.7.4 |
| MetaCyc | 1.2.7.4 |
| UniProtKB/Swiss-Prot |
| O29165, ACDA1_ARCFU; | Q8TRZ4, ACDA1_METAC; | Q46G04, ACDA1_METBF; |
| Q8TXF7, ACDA1_METKA; | Q49161, ACDA1_METMA; | Q08368, ACDA1_METTE; |
| O30274, ACDA2_ARCFU; | Q8TJC6, ACDA2_METAC; | Q49163, ACDA2_METMA; |
| Q9C4Z4, ACDA2_METTE; | Q8THW2, ACDA3_METAC; | Q12XL7, ACDA_METBU; |
| Q57617, ACDA_METJA; | P26692, ACDA_METSH; | O27743, ACDA_METTH; |
| P59934, COOS1_CARHZ; | Q8TKW2, COOS1_METAC; | Q8Q0L5, COOS1_METMA; |
| Q9F8A8, COOS2_CARHZ; | Q8TR73, COOS2_METAC; | Q8PUN1, COOS2_METMA; |
| O28429, COOS_ARCFU; | Q58138, COOS_METJA; | Q8TXX3, COOS_METKA; |
| P31896, COOS_RHORU; | P27989, DCMB_MOOTH; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-