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ENZYME

ENZYME entry: EC 1.2.7.4

Accepted Name
anaerobic carbon-monoxide dehydrogenase
Alternative Name(s)
carbon-monoxide dehydrogenase (ferredoxin)
Ni-CODH
Reaction catalysed
CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • This prokaryotic enzyme catalyzes the reversible reduction of CO2 to CO.
  • The electrons are transferred to redox proteins such as ferredoxin.
  • In purple sulfur bacteria and methanogenic archaea it catalyzes the oxidation of CO to CO2, which is incorporated by the Calvin-Benson- Basham cycle or released, respectively.
  • In acetogenic and sulfate-reducing microbes it catalyzes the reduction of CO2 to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, with which the enzyme forms a tight complex in those organisms.
  • In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2 which catalyze the overall reaction: CO + H2O = CO2 + H2. cf. EC 1.2.5.3.
  • Formerly EC 1.2.99.2.
Cross-references
BRENDA1.2.7.4
EC2PDB1.2.7.4
ExplorEnz1.2.7.4
PRIAM enzyme-specific profiles1.2.7.4
KEGG Ligand Database for Enzyme Nomenclature1.2.7.4
IUBMB Enzyme Nomenclature1.2.7.4
IntEnz1.2.7.4
MEDLINEFind literature relating to 1.2.7.4
MetaCyc1.2.7.4
Rhea expert-curated reactions1.2.7.4
UniProtKB/Swiss-Prot
O29165, ACDA1_ARCFUQ8TRZ4, ACDA1_METACQ46G04, ACDA1_METBF
Q8TXF7, ACDA1_METKAQ49161, ACDA1_METMAQ08368, ACDA1_METTE
O30274, ACDA2_ARCFUQ8TJC6, ACDA2_METACQ49163, ACDA2_METMA
Q9C4Z4, ACDA2_METTEQ8THW2, ACDA3_METACQ12XL7, ACDA_METBU
Q57617, ACDA_METJAP26692, ACDA_METSHO27743, ACDA_METTH
P59934, COOS1_CARHZQ8TKW2, COOS1_METACQ8Q0L5, COOS1_METMA
Q9F8A8, COOS2_CARHZQ8TR73, COOS2_METACQ8PUN1, COOS2_METMA
O28429, COOS_ARCFUQ58138, COOS_METJAQ8TXX3, COOS_METKA
P31896, COOS_RHORUP27989, DCMB_MOOTH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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