A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.2.7.4
Accepted Name |
Anaerobic carbon-monoxide dehydrogenase.
|
Alternative Name(s) |
Carbon-monoxide dehydrogenase (ferredoxin). |
Ni-CODH. |
Reaction catalysed |
CO + H(2)O + 2 oxidized ferredoxin <=> CO(2) + 2 reduced ferredoxin + 2 H(+) |
Cofactor(s) |
Fe cation; Ni(2+); Zn(2+).
|
Comment(s) |
- This prokaryotic enzyme catalyzes the reversible reduction of CO(2)
to CO.
- The electrons are transferred to redox proteins such as ferredoxin.
- In purple sulfur bacteria and methanogenic archaea it catalyzes the
oxidation of CO to CO(2), which is incorporated by the Calvin-Benson-
Basham cycle or released, respectively.
- In acetogenic and sulfate-reducing microbes it catalyzes the
reduction of CO(2) to CO, which is incorporated into acetyl CoA by
EC 2.3.1.169, with which the enzyme forms a tight complex in those
organisms.
- In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S
protein EC 1.12.7.2 which catalyze the overall reaction: CO + H(2)O =
CO(2) + H(2).
- Cf. EC 1.2.5.3.
- Formerly EC 1.2.99.2.
|
Cross-references |
BRENDA | 1.2.7.4 |
EC2PDB | 1.2.7.4 |
ExplorEnz | 1.2.7.4 |
PRIAM enzyme-specific profiles | 1.2.7.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.2.7.4 |
IUBMB Enzyme Nomenclature | 1.2.7.4 |
IntEnz | 1.2.7.4 |
MEDLINE | Find literature relating to 1.2.7.4 |
MetaCyc | 1.2.7.4 |
UniProtKB/Swiss-Prot |
O29165, ACDA1_ARCFU; | Q8TRZ4, ACDA1_METAC; | Q46G04, ACDA1_METBF; |
Q8TXF7, ACDA1_METKA; | Q49161, ACDA1_METMA; | Q08368, ACDA1_METTE; |
O30274, ACDA2_ARCFU; | Q8TJC6, ACDA2_METAC; | Q49163, ACDA2_METMA; |
Q9C4Z4, ACDA2_METTE; | Q8THW2, ACDA3_METAC; | Q12XL7, ACDA_METBU; |
Q57617, ACDA_METJA; | P26692, ACDA_METSH; | O27743, ACDA_METTH; |
P59934, COOS1_CARHZ; | Q8TKW2, COOS1_METAC; | Q8Q0L5, COOS1_METMA; |
Q9F8A8, COOS2_CARHZ; | Q8TR73, COOS2_METAC; | Q8PUN1, COOS2_METMA; |
O28429, COOS_ARCFU; | Q58138, COOS_METJA; | Q8TXX3, COOS_METKA; |
P31896, COOS_RHORU; | P27989, DCMB_MOOTH; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
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