ID 1.2.7.7 DE 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). AN 2-ketoisovalerate ferredoxin reductase. AN 2-oxoisovalerate ferredoxin reductase. AN 3-methyl-2-oxobutanoate synthase (ferredoxin). AN branched-chain ketoacid ferredoxin reductase. AN branched-chain oxo acid ferredoxin reductase. AN ketoisovalerate ferredoxin reductase. AN ketoisovalerate oxidoreductase. AN keto-valine-ferredoxin oxidoreductase. AN VOR. CA 3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CA 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]. CC -!- The enzyme is CoA-dependent and contains thiamine diphosphate and CC iron-sulfur clusters. CC -!- Preferentially utilizes 2-oxo-acid derivatives of branched chain CC amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- CC pentanoate, and 2-oxobutanoate. CC -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of CC enzymes that reversibly catalyze the oxidative decarboxylation of CC different 2-oxoacids to form their CoA derivatives, and are CC differentiated based on their substrate specificity. CC -!- For examples of other members of this family, see EC 1.2.7.1 and CC EC 1.2.7.3. DR Q9UYY9, PORC_PYRAB ; P84819, PORC_PYREN ; Q51799, PORC_PYRFU ; DR O58411, PORC_PYRHO ; Q5JIK2, PORC_THEKO ; P84820, PORC_THELN ; DR O26801, VORA_METTH ; Q9UYZ1, VORA_PYRAB ; Q51801, VORA_PYRFU ; DR O58413, VORA_PYRHO ; O26800, VORB_METTH ; P80908, VORB_METTM ; DR Q9UYZ2, VORB_PYRAB ; Q51802, VORB_PYRFU ; O58414, VORB_PYRHO ; DR O26799, VORC_METTH ; P80909, VORC_METTM ; Q9UYZ0, VORD_PYRAB ; DR Q51800, VORD_PYRFU ; O58412, VORD_PYRHO ; //