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ENZYME entry: EC 1.21.1.1

Accepted Name
Iodotyrosine deiodinase.
Alternative Name(s)
Iodotyrosine dehalogenase 1.
Reaction catalysed
L-tyrosine + 2 NADP(+) + 2 iodide <=> 3,5-diiodo-L-tyrosine + 2 NADPH
Cofactor(s)
FMN.
Comment(s)
  • The enzyme activity has only been demonstrated in the direction of 3-deiodination.
  • Formerly EC 1.22.1.1.
Cross-references
BRENDA1.21.1.1
EC2PDB1.21.1.1
ExplorEnz1.21.1.1
PRIAM enzyme-specific profiles1.21.1.1
KEGG Ligand Database for Enzyme Nomenclature1.21.1.1
IUBMB Enzyme Nomenclature1.21.1.1
IntEnz1.21.1.1
MEDLINEFind literature relating to 1.21.1.1
MetaCyc1.21.1.1
Rhea expert-curated reactions1.21.1.1
UniProtKB/Swiss-Prot
Q6PHW0, IYD1_HUMAN;  Q9DCX8, IYD1_MOUSE;  Q6TA49, IYD1_PIG;  
Q5REW1, IYD1_PONAB;  Q5BK17, IYD1_RAT;  

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