ID 1.21.3.3 DE Reticuline oxidase. AN Berberine bridge enzyme. AN Berberine-bridge-forming enzyme. AN Tetrahydroprotoberberine synthase. CA (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2). CF FAD. CC -!- Acts on (S)-reticuline and related compounds, converting the N-methyl CC group into the methylene bridge ('berberine bridge') of (S)- CC tetrahydroprotoberberines. CC -!- The product of the reaction, (S)-scoulerine, is a precursor of CC protopine, protoberberine and benzophenanthridine alkaloid CC biosynthesis in plants. CC -!- Formerly EC 1.5.3.9. PR PROSITE; PDOC00674; DR P30986, RETO_ESCCA ; P93479, RETO_PAPSO ; //