ID   1.21.3.3
DE   reticuline oxidase.
AN   berberine bridge enzyme.
AN   berberine-bridge-forming enzyme.
AN   tetrahydroprotoberberine synthase.
CA   (S)-reticuline + O2 = (S)-scoulerine + H2O2 + H(+).
CC   -!- Acts on (S)-reticuline and related compounds, converting the N-methyl
CC       group into the methylene bridge ('berberine bridge') of (S)-
CC       tetrahydroprotoberberines.
CC   -!- The product of the reaction, (S)-scoulerine, is a precursor of
CC       protopine, protoberberine and benzophenanthridine alkaloid
CC       biosynthesis in plants.
CC   -!- Formerly EC 1.5.3.9.
DR   P30986, RETO_ESCCA ;  P93479, RETO_PAPSO ;
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