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ENZYME entry: EC 1.21.4.5

Accepted Name
Tetrachlorohydroquinone reductive dehalogenase.
Reaction catalysed
  • 2,6-dichlorohydroquinone + Cl(-) + glutathione disulfide <=> 2,3,6-trichlorohydroquinone + 2 glutathione
  • 2,3,6-trichlorohydroquinone + Cl(-) + glutathione disulfide <=> 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
Comment(s)
  • The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6- dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent.
  • The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6- (glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)- hydroquinone instead of its normal products.
Cross-references
BRENDA1.21.4.5
EC2PDB1.21.4.5
ExplorEnz1.21.4.5
PRIAM enzyme-specific profiles1.21.4.5
KEGG Ligand Database for Enzyme Nomenclature1.21.4.5
IUBMB Enzyme Nomenclature1.21.4.5
IntEnz1.21.4.5
MEDLINEFind literature relating to 1.21.4.5
MetaCyc1.21.4.5
Rhea expert-curated reactions1.21.4.5
UniProtKB/Swiss-Prot
Q03520, PCPC_SPHCR

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