Home  |  Contact

ENZYME entry: EC 1.21.98.4

Accepted Name
PqqA peptide cyclase.
Reaction catalysed
A PqqA peptide + S-adenosyl-L-methionine <=> a PqqA peptide with linked Glu-Tyr residues + 5'-deoxyadenosine + L-methionine
Comment(s)
  • This bacterial enzyme, which is a member of the radical SAM protein family, catalyzes the formation of a C-C bond between C-4 of glutamate and C-3 of tyrosine residues of the PqqA protein (which are separated by three amino acid residues).
  • This is the first enzymic step in the biosynthesis of the bacterial enzyme cofactor pyrroloquinoline quinone (PQQ).
  • The reaction is dependent on the presence of flavodoxin and the accessory protein PqqD.
Cross-references
BRENDA1.21.98.4
EC2PDB1.21.98.4
ExplorEnz1.21.98.4
PRIAM enzyme-specific profiles1.21.98.4
KEGG Ligand Database for Enzyme Nomenclature1.21.98.4
IUBMB Enzyme Nomenclature1.21.98.4
IntEnz1.21.98.4
MEDLINEFind literature relating to 1.21.98.4
MetaCyc1.21.98.4
UniProtKB/Swiss-Prot
Q6F9I9, PQQE_ACIAD;  B7H2Y0, PQQE_ACIB3;  B7I6M8, PQQE_ACIB5;  
B2I0I5, PQQE_ACIBC;  B0VQD7, PQQE_ACIBS;  B0V494, PQQE_ACIBY;  
P07782, PQQE_ACICA;  C1DEW5, PQQE_AZOVD;  Q89FG1, PQQE_BRADU;  
B2VL10, PQQE_ERWT9;  Q9L3B0, PQQE_GLUOX;  Q0BQS8, PQQE_GRABC;  
B5XX58, PQQE_KLEP3;  A6T9H2, PQQE_KLEP7;  P27507, PQQE_KLEPN;  
P59748, PQQE_KLUIN;  B7KXC6, PQQE_METC4;  Q608P0, PQQE_METCA;  
P71517, PQQE_METEA;  A9W3R0, PQQE_METEP;  B8ITV7, PQQE_METNO;  
B1ZIB2, PQQE_METPB;  B1LUE7, PQQE_METRJ;  B0UE13, PQQE_METS4;  
B8ENI9, PQQE_METSB;  Q48CT3, PQQE_PSE14;  B7VAB6, PQQE_PSEA8;  
Q02LD6, PQQE_PSEAB;  Q9I2C0, PQQE_PSEAE;  Q4K4U8, PQQE_PSEF5;  
A4XTR4, PQQE_PSEMY;  A5VXG4, PQQE_PSEP1;  Q88QV8, PQQE_PSEPK;  
Q88A84, PQQE_PSESM;  Q4ZMC1, PQQE_PSEU2;  Q01060, PQQE_PSEVU;  
O33506, PQQE_RAHAQ;  Q9EXU8, PQQE_RHIME;  Q6N8F3, PQQE_RHOPA;  
Q5LTB4, PQQE_RUEPO;  P59749, PQQE_STRRO;  Q8PHY1, PQQE_XANAC;  
Q3BQI4, PQQE_XANC5;  Q4UXI4, PQQE_XANC8;  B0RQ25, PQQE_XANCB;  
Q8P6M7, PQQE_XANCP;  Q2P4Y9, PQQE_XANOM;  B2SSW3, PQQE_XANOP;  
Q5H234, PQQE_XANOR;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.98.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-