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ENZYME entry: EC 1.21.99.3

Accepted Name
Thyroxine 5-deiodinase.
Alternative Name(s)
Diiodothyronine 5'-deiodinase.
Iodothyronine 5-deiodinase.
Iodothyronine inner ring monodeiodinase.
Type III iodothyronine deiodinase.
Reaction catalysed
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H(+) <=> L-thyroxine + reduced acceptor
Comment(s)
  • The enzyme activity has only been demonstrated in the direction of 5-deiodination.
  • This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
  • Formerly EC 1.97.1.11.
Cross-references
PROSITEPDOC00172 ; PDOC00925
BRENDA1.21.99.3
EC2PDB1.21.99.3
ExplorEnz1.21.99.3
PRIAM enzyme-specific profiles1.21.99.3
KEGG Ligand Database for Enzyme Nomenclature1.21.99.3
IUBMB Enzyme Nomenclature1.21.99.3
IntEnz1.21.99.3
MEDLINEFind literature relating to 1.21.99.3
MetaCyc1.21.99.3
Rhea expert-curated reactions1.21.99.3
UniProtKB/Swiss-Prot
Q5I3B1, IOD3_BOVIN;  O42412, IOD3_CHICK;  P55073, IOD3_HUMAN;  
P49898, IOD3_LITCT;  Q91ZI8, IOD3_MOUSE;  Q6QN11, IOD3_PIG;  
P49897, IOD3_RAT;  Q6DN07, IOD3_SHEEP;  A7YD35, IOD3_SPAAU;  
P49899, IOD3_XENLA;  

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