Expasy logo

ENZYME

ENZYME entry: EC 1.21.99.3

Accepted Name
thyroxine 5-deiodinase
Alternative Name(s)
diiodothyronine 5'-deiodinase
iodothyronine 5-deiodinase
iodothyronine inner ring monodeiodinase
type III iodothyronine deiodinase
Reaction catalysed
3,3',5'-triiodo-L-thyronine + A + H(+) + iodide <=> AH2 + L-thyroxine
Comment(s)
  • The enzyme activity has only been demonstrated in the direction of 5-deiodination.
  • This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
  • Formerly EC 1.97.1.11.
Cross-references
BRENDA1.21.99.3
EC2PDB1.21.99.3
ExplorEnz1.21.99.3
PRIAM enzyme-specific profiles1.21.99.3
KEGG Ligand Database for Enzyme Nomenclature1.21.99.3
IUBMB Enzyme Nomenclature1.21.99.3
IntEnz1.21.99.3
MEDLINEFind literature relating to 1.21.99.3
MetaCyc1.21.99.3
Rhea expert-curated reactions1.21.99.3
UniProtKB/Swiss-Prot
Q5I3B1, IOD3_BOVINO42412, IOD3_CHICKP55073, IOD3_HUMAN
P49898, IOD3_LITCTQ91ZI8, IOD3_MOUSEQ6QN11, IOD3_PIG
P49897, IOD3_RATQ6DN07, IOD3_SHEEPA7YD35, IOD3_SPAAU
P49899, IOD3_XENLA

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-