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ENZYME

ENZYME entry: EC 1.21.99.3

PURL: https://purl.expasy.org/enzyme/EC/1.21.99.3
Accepted Name
thyroxine 5-deiodinase
Alternative Name(s)
diiodothyronine 5'-deiodinase
iodothyronine 5-deiodinase
iodothyronine inner ring monodeiodinase
type III iodothyronine deiodinase
Reaction catalysed
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Comment(s)
  • The enzyme activity has only been demonstrated in the direction of 5-deiodination.
  • This removal of the 5-iodine, i.e. from the inner ring, largely inactivates the hormone thyroxine.
  • Formerly EC 1.97.1.11.
Cross-references
BRENDA1.21.99.3
EC2PDB1.21.99.3
ExplorEnz1.21.99.3
KEGG Ligand Database for Enzyme Nomenclature1.21.99.3
IUBMB Enzyme Nomenclature1.21.99.3
MEDLINEFind literature relating to 1.21.99.3
MetaCyc1.21.99.3
Rhea expert-curated reactions1.21.99.3
UniProtKB/Swiss-Prot
P49894, IOD1_CANLFO42411, IOD1_CHICKQ6V915, IOD1_FELCA
P49895, IOD1_HUMANQ61153, IOD1_MOUSEQ6QN13, IOD1_PIG
A4GT88, IOD1_RABITP24389, IOD1_RATQ95N00, IOD1_SUNMU
Q2QEI3, IOD1_XENLAP49898, IOD3_AQUCTQ5I3B1, IOD3_BOVIN
O42412, IOD3_CHICKP55073, IOD3_HUMANQ91ZI8, IOD3_MOUSE
Q6QN11, IOD3_PIGP49897, IOD3_RATQ6DN07, IOD3_SHEEP
A7YD35, IOD3_SPAAUP49899, IOD3_XENLA

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