ENZYME entry: EC 1.21.99.3
Accepted Name |
Thyroxine 5-deiodinase.
|
Alternative Name(s) |
Diiodothyronine 5'-deiodinase. |
Iodothyronine 5-deiodinase. |
Iodothyronine inner ring monodeiodinase. |
Type III iodothyronine deiodinase. |
Reaction catalysed |
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H(+) <=> L-thyroxine + reduced acceptor |
Comment(s) |
- The enzyme activity has only been demonstrated in the direction of
5-deiodination.
- This removal of the 5-iodine, i.e. from the inner ring, largely
inactivates the hormone thyroxine.
- Formerly EC 1.97.1.11.
|
Cross-references |
PROSITE | PDOC00172 ; PDOC00925 |
BRENDA | 1.21.99.3 |
EC2PDB | 1.21.99.3 |
ExplorEnz | 1.21.99.3 |
PRIAM enzyme-specific profiles | 1.21.99.3 |
KEGG Ligand Database for Enzyme Nomenclature | 1.21.99.3 |
IUBMB Enzyme Nomenclature | 1.21.99.3 |
IntEnz | 1.21.99.3 |
MEDLINE | Find literature relating to 1.21.99.3 |
MetaCyc | 1.21.99.3 |
Rhea expert-curated reactions | 1.21.99.3 |
UniProtKB/Swiss-Prot |
Q5I3B1, IOD3_BOVIN; | O42412, IOD3_CHICK; | P55073, IOD3_HUMAN; |
P49898, IOD3_LITCT; | Q91ZI8, IOD3_MOUSE; | Q6QN11, IOD3_PIG; |
P49897, IOD3_RAT; | Q6DN07, IOD3_SHEEP; | A7YD35, IOD3_SPAAU; |
P49899, IOD3_XENLA; |
|
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