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ENZYME entry: EC 1.3.1.105

Accepted Name
2-methylene-furan-3-one reductase.
Alternative Name(s)
Enone oxidoreductase.
Reaction catalysed
4-hydroxy-2,5-dimethylfuran-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + NADPH
Comment(s)
  • The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits.
  • It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus).
  • The enzyme can also act on derivatives substituted at the methylene functional group.
  • The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2- ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso.
  • NADPH is the preferred cofactor.
Cross-references
BRENDA1.3.1.105
EC2PDB1.3.1.105
ExplorEnz1.3.1.105
PRIAM enzyme-specific profiles1.3.1.105
KEGG Ligand Database for Enzyme Nomenclature1.3.1.105
IUBMB Enzyme Nomenclature1.3.1.105
IntEnz1.3.1.105
MEDLINEFind literature relating to 1.3.1.105
MetaCyc1.3.1.105
Rhea expert-curated reactions1.3.1.105
UniProtKB/Swiss-Prot
Q941I0, ENOXC_FRAAN;  Q84V25, ENOXE_FRAAN;  O23939, ENOX_FRAVE;  
K4BW79, ENOX_SOLLC;  

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