ENZYME

ENZYME entry: EC 1.3.1.105

Accepted Name

2-methylene-furan-3-one reductase.

Alternative Name(s)

Enone oxidoreductase.

Reaction catalysed

4-hydroxy-2,5-dimethylfuran-3(2H)-one + NADP(+) <=> 4-hydroxy-5-methyl-2-methylenefuran-3(2H)-one + NADPH

Comment(s)

The enzyme was dicovered in strawberry (Fragaria x ananassa), where it produces furaneol, one of the major aroma compounds in the fruits.
It has also been detected in tomato (Solanum lycopersicum) and pineapple (Ananas comosus).
The enzyme can also act on derivatives substituted at the methylene functional group.
The enzyme from the yeast Saccharomyces cerevisiae acts on (2E)-2- ethylidene-4-hydroxy-5-methylfuran-3(2H)-one and produces homofuraneol, an important aroma compound in soy sauce and miso.
NADPH is the preferred cofactor.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature