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ENZYME entry: EC 1.3.1.106

Accepted Name
cobalt-precorrin-6A reductase.
Reaction catalysed
Co-precorrin-6B + NAD(+) <=> Co-precorrin-6A + H(+) + NADH
Comment(s)
  • The enzyme, which participates in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyzes the reduction of the double bond between C-18 and C-19 of cobalt- precorrin-6A.
  • The enzyme from the bacterium Bacillus megaterium has no activity with NADPH.
  • See EC 1.3.1.54 for the corresponding enzyme that participates in the aerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA1.3.1.106
EC2PDB1.3.1.106
ExplorEnz1.3.1.106
PRIAM enzyme-specific profiles1.3.1.106
KEGG Ligand Database for Enzyme Nomenclature1.3.1.106
IUBMB Enzyme Nomenclature1.3.1.106
IntEnz1.3.1.106
MEDLINEFind literature relating to 1.3.1.106
MetaCyc1.3.1.106
Rhea expert-curated reactions1.3.1.106
UniProtKB/Swiss-Prot
Q57972, CBIJ_METJA;  Q977V1, CBIJ_METMI;  O27083, CBIJ_METTH;  
O87691, CBIJ_PRIMG;  Q05591, CBIJ_SALTY;  P72711, CBIJ_SYNY3;  

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